Traffic Crash Characteristics in Shenzhen, China from 2014 to 2016

Road traffic crashes cause fatalities and injuries of both drivers/passengers in vehicles and pedestrians outside, thus challenge public health especially in big cities in developing countries like China. Previous efforts mainly focus on a specific crash type or causation to examine the crash characteristics in China while lacking the characteristics of various crash types, factors, and the interplay between them. This study investigated the crash characteristics in Shenzhen, one of the biggest four cities in China, based on the police-reported crashes from 2014 to 2016. The descriptive characteristics were reported in detail with respect to each of the crash attributes. Based on the recorded crash locations, the land-use pattern was obtained as one of the attributes for each crash. Then, the relationship between the attributes in motor-vehicle-involved crashes was examined using the Bayesian network analysis. We revealed the distinct crash characteristics observed between the examined levels of each attribute, as well the interplay between the attributes. This study provides an insight into the crash characteristics in Shenzhen, which would help understand the driving behavior of Chinese drivers, identify the traffic safety problems, guide the research focuses on advanced driver assistance systems (ADASs) and traffic management countermeasures in China

Communication-Efficient Topologies for Decentralized Learning with O(1)O(1) Consensus Rate

Decentralized optimization is an emerging paradigm in distributed learning in which agents achieve network-wide solutions by peer-to-peer communication without the central server. Since communication tends to be slower than computation, when each agent communicates with only a few neighboring agents per iteration, they can complete iterations faster than with more agents or a central server. However, the total number of iterations to reach a network-wide solution is affected by the speed at which the agents' information is ``mixed'' by communication. We found that popular communication topologies either have large maximum degrees (such as stars and complete graphs) or are ineffective at mixing information (such as rings and grids). To address this problem, we propose a new family of topologies, EquiTopo, which has an (almost) constant degree and a network-size-independent consensus rate that is used to measure the mixing efficiency. In the proposed family, EquiStatic has a degree of $\Theta(\ln(n))$, where $n$ is the network size, and a series of time-dependent one-peer topologies, EquiDyn, has a constant degree of 1. We generate EquiDyn through a certain random sampling procedure. Both of them achieve an $n$-independent consensus rate. We apply them to decentralized SGD and decentralized gradient tracking and obtain faster communication and better convergence, theoretically and empirically. Our code is implemented through BlueFog and available at \url{https://github.com/kexinjinnn/EquiTopo}Comment: NeurIPS 202

Florence-2: Advancing a Unified Representation for a Variety of Vision Tasks

We introduce Florence-2, a novel vision foundation model with a unified, prompt-based representation for a variety of computer vision and vision-language tasks. While existing large vision models excel in transfer learning, they struggle to perform a diversity of tasks with simple instructions, a capability that implies handling the complexity of various spatial hierarchy and semantic granularity. Florence-2 was designed to take text-prompt as task instructions and generate desirable results in text forms, whether it be captioning, object detection, grounding or segmentation. This multi-task learning setup demands large-scale, high-quality annotated data. To this end, we co-developed FLD-5B that consists of 5.4 billion comprehensive visual annotations on 126 million images, using an iterative strategy of automated image annotation and model refinement. We adopted a sequence-to-sequence structure to train Florence-2 to perform versatile and comprehensive vision tasks. Extensive evaluations on numerous tasks demonstrated Florence-2 to be a strong vision foundation model contender with unprecedented zero-shot and fine-tuning capabilities

Role of long non-coding RNA in chemoradiotherapy resistance of nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelial cells. Common treatment methods for NPC include radiotherapy, chemotherapy, and surgical intervention. Despite these approaches, the prognosis for NPC remains poor due to treatment resistance and recurrence. Hence, there is a crucial need for more comprehensive research into the mechanisms underlying treatment resistance in NPC. Long non coding RNAs (LncRNAs) are elongated RNA molecules that do not encode proteins. They paly significant roles in various biological processes within tumors, such as chemotherapy resistance, radiation resistance, and tumor recurrence. Recent studies have increasingly unveiled the mechanisms through which LncRNAs contribute to treatment resistance in NPC. Consequently, LncRNAs hold promise as potential biomarkers and therapeutic targets for diagnosing NPC. This review provides an overview of the role of LncRNAs in NPC treatment resistance and explores their potential as therapeutic targets for managing NPC

Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation

We studied serum proteomic profiling in patients with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) by two-dimensional gel electrophoresis (2-DE) and mass spectrometry analysis. The expression of a group of proteins, haptoglobin (Hp), alpha-1-antitrypsin, apolipoprotein A-IV, serum paraoxonase and Zn-alpha-glycoprotein were increased and the proteins, clusterin precursor, alpha-2-macroglobulin, serum amyloid protein precursor, sex hormone-binding globulin, serotransferrin and complement C4 were decreased in patients with extensive chronic GVHD (cGVHD). Serum haptoglobin (Hp) levels in patients with cGVHD were demonstrated to be statistically higher than in patients without cGVHD and normal controls (p < 0.01). We used immunoblotting and PCR in combination with 2-DE gel image analysis to determine Hp polymorphisms in 25 allo-HCT patients and 16 normal donors. The results demonstrate that patients with cGVHD had a higher incidence of HP 2-2 phenotype (43.8%), in comparison to the patients without cGVHD (0%) and normal donors (18.7%), suggesting the possibility that specific Hp polymorphism may play a role in the development of cGVHD after allo-HCT. In this study, quantitative serum Hp levels were shown to be related to cGVHD development. Further, the data suggest the possibility that specific Hp polymorphisms may be associated with cGVHD development and warrant further investigation

Ginseng extract improves pancreatic islet injury and promotes β-cell regeneration in T2DM mice

IntroductionPanax ginseng C. A. Mey. (Araliaceae; Ginseng Radix et Rhizoma), a traditional plant commonly utilized in Eastern Asia, has demonstrated efficacy in treating neuro-damaging diseases and diabetes mellitus. However, its precise roles and mechanism in alleviating type 2 diabetes mellitus (T2DM) need further study. The objective of this study is to explore the pharmacological effects of ginseng extract and elucidate its potential mechanisms in protecting islets and promoting β-cell regeneration.MethodsThe T2DM mouse model was induced through streptozotocin combined with a high-fat diet. Two batches of mice were sacrificed on the 7th and 28th days following ginseng extract administration. Body weight, fasting blood glucose levels, and glucose tolerance were detected. Morphological changes in the pancreatic islets were examined via H &amp; E staining. Levels of serum insulin, glucagon, GLP-1, and inflammatory factors were measured using ELISA. The ability of ginseng extract to promote pancreatic islet β-cell regeneration was evaluated through insulin &amp; PCNA double immunofluorescence staining. Furthermore, the mechanism behind β-cells regeneration was explored through insulin &amp; glucagon double immunofluorescence staining, accompanied by immunohistochemical staining and western blot analyses.Results and DiscussionThe present research revealed that ginseng extract alleviates symptoms of T2DM in mice, including decreased blood glucose levels and improved glucose tolerance. Serum levels of insulin, GLP-1, and IL-10 increased following the administration of ginseng extract, while levels of glucagon, TNF-α, and IL-1β decreased. Ginseng extract preserved normal islet morphology, increased nascent β-cell population, and inhibited inflammatory infiltration within the islets, moreover, it decreased α-cell proportion while increasing β-cell proportion. Mechanistically, ginseng extract might inhibit ARX and MAFB expressions, increase MAFA level to aid in α-cell to β-cell transformation, and activate AKT-FOXM1/cyclin D2 to enhance β-cell proliferation. Our study suggests that ginseng extract may be a promising therapy in treating T2DM, especially in those with islet injury

Divergent Evolution of TRC Genes in Mammalian Niche Adaptation

Mammals inhabit a wide variety of ecological niches, which in turn can be affected by various ecological factors, especially in relation to immunity. The canonical TRC repertoire (TRAC, TRBC, TRGC, and TRDC) codes C regions of T cell receptor chains that form the primary antigen receptors involved in the activation of cellular immunity. At present, little is known about the correlation between the evolution of mammalian TRC genes and ecological factors. In this study, four types canonical of TRC genes were identified from 37 mammalian species. Phylogenetic comparative methods (phyANOVA and PGLS) and selective pressure analyses among different groups of ecological factors (habitat, diet, and sociality) were carried out. The results showed that habitat was the major ecological factor shaping mammalian TRC repertoires. Specifically, trade-off between TRGC numbers and positive selection of TRAC and the balanced evolutionary rates between TRAC and TRDC genes were speculated as two main mechanisms in adaption to habitat and sociality. Overall, our study suggested divergent mechanisms for the evolution of TRCs, prompting mammalian immunity adaptions within diverse niches

New Germplasm for Breeding: Pink-flowered and White-fruited Strawberry

Most strawberry plants have white flowers and red fruit. We developed a new strawberry selection with pink flowers and white fruit, and named it G23. Basic phenotypic data were recorded over years of observation and experimentation with the flower crown diameter, petal color, and rate of fruit set, as well as fruit skin color, flesh color, seed color and attachment status, fruit weight and shape, soluble solids contents, and firmness. We found that G23 bloomed with a stable pink flower and produced white fruit consistently with a relatively high fruit-set rate compared with its female parent, ‘Pink Panda’. G23 displayed high resistance to Fusarium wilt (Fusarium oxysporum) and anthracnose (Colletotrichum spp.). It is also tolerant of high temperatures (up to 40 °C) and long-term drought. The asexual propagation ability of G23 is high, with ∼60 to 100 stolon ramets formed during the summer. In summary, this new pink-flowered and white-fruited strawberry germplasm is suitable for ornamental use, as a result of its remarkable flowering and fruiting characteristics. In addition, it provides opportunities for innovative strawberry germplasm for future breeding

Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation

Abstract We studied serum proteomic profiling in patients with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) by two-dimensional gel electrophoresis (2-DE) and mass spectrometry analysis. The expression of a group of proteins, haptoglobin (Hp), alpha-1-antitrypsin, apolipoprotein A-IV, serum paraoxonase and Zn-alpha-glycoprotein were increased and the proteins, clusterin precursor, alpha-2-macroglobulin, serum amyloid protein precursor, sex hormone-binding globulin, serotransferrin and complement C4 were decreased in patients with extensive chronic GVHD (cGVHD). Serum haptoglobin (Hp) levels in patients with cGVHD were demonstrated to be statistically higher than in patients without cGVHD and normal controls (p &lt; 0.01). We used immunoblotting and PCR in combination with 2-DE gel image analysis to determine Hp polymorphisms in 25 allo-HCT patients and 16 normal donors. The results demonstrate that patients with cGVHD had a higher incidence of HP 2-2 phenotype (43.8%), in comparison to the patients without cGVHD (0%) and normal donors (18.7%), suggesting the possibility that specific Hp polymorphism may play a role in the development of cGVHD after allo-HCT. In this study, quantitative serum Hp levels were shown to be related to cGVHD development. Further, the data suggest the possibility that specific Hp polymorphisms may be associated with cGVHD development and warrant further investigation.Peer Reviewe