Stratification analysis for associations between genotypes of Nalp3 and the risk of silicosis.

<p>^*ORs were obtained from a logistic regression model that was adjusted for age, smoking status, and CDE.</p><p>Stratification analysis for associations between genotypes of Nalp3 and the risk of silicosis.</p

Stratification analysis for associations between genotypes of caspase-1 and the risk of silicosis.

<p>^*ORs were obtained from logistic regression models that were adjusted for age, smoking status, and CDE.</p><p>Stratification analysis for associations between genotypes of caspase-1 and the risk of silicosis.</p

Summary of the single nucleotide polymorphisms(SNPs) among the 3 candidate genes.

<p>MAF, minor allele frequency.</p><p>RS#, reference SNP identification number.</p><p>Summary of the single nucleotide polymorphisms(SNPs) among the 3 candidate genes.</p

Lifestyle and occupational characteristics of patients with silicosis and control subjects.

<p>^a All tests were 2-sided.</p><p>^bFormer smokers and current smokers were categorized as having a smoking status of “yes.”</p><p>^cSubjects who never smoked were excluded from the calculation.</p><p>CDE, cumulative dust exposure.</p><p>Lifestyle and occupational characteristics of patients with silicosis and control subjects.</p

Genotype frequencies and associated risks of silicosis in case and control subjects.

<p>^a Data were calculated using unconditional logistic regression and adjusting for age, smoking status, and CDE.</p><p>CI, confidence interval; OR, odds ratio.</p><p>Genotype frequencies and associated risks of silicosis in case and control subjects.</p

Stratification analysis for associations between genotypes of IL-1β and the risk of silicosis.

<p>^*ORs were obtained from a logistic regression model that was adjusted for age, smoking status, and CDE.</p><p>Stratification analysis for associations between genotypes of IL-1β and the risk of silicosis.</p

The geometric mean FFs and passing rate for 10 models of FFR.

<p>Abbreviation : FF, fit factor; FFR, Filtering facepiece respirator; GSD, geometric standard deviation.</p>*<p>The geometric mean fit factors with the different superscript letters (A to G) are significantly different.</p

Risk Identification and Prediction of Coal Workers’ Pneumoconiosis in Kailuan Colliery Group in China: A Historical Cohort Study

<div><p>Background</p><p>Prior to 1970, coal mining technology and prevention measures in China were poor. Mechanized coal mining equipment and advanced protection measures were continuously installed in the mines after 1970. All these improvements may have resulted in a change in the incidence of coal workers’ pneumoconiosis (CWP). Therefore, it is important to identify the characteristics of CWP today and trends for the incidence of CWP in the future.</p><p>Methodology/Principal Findings</p><p>A total of 17,023 coal workers from the Kailuan Colliery Group were studied. A life-table method was used to calculate the cumulative incidence rate of CWP and predict the number of new CWP patients in the future. The probability of developing CWP was estimated by a multilayer perceptron artificial neural network for each coal worker without CWP. The results showed that the cumulative incidence rates of CWP for tunneling, mining, combining, and helping workers were 31.8%, 27.5%, 24.2%, and 2.6%, respectively, during the same observation period of 40 years. It was estimated that there would be 844 new CWP cases among 16,185 coal workers without CWP within their life expectancy. There would be 273.1, 273.1, 227.6, and 69.9 new CWP patients in the next <10, 10-, 20-, and 30- years respectively in the study cohort within their life expectancy. It was identified that coal workers whose risk probabilities were over 0.2 were at high risk for CWP, and whose risk probabilities were under 0.1 were at low risk.</p><p>Conclusion/Significance</p><p>The present and future incidence trends of CWP remain high among coal workers. We suggest that coal workers at high risk of CWP undergo a physical examination for pneumoconiosis every year, and the coal workers at low risk of CWP be examined every 5 years.</p></div

The mean and standard deviation for all 25 anthropometric dimensions based on gender and all participants.

<p>The mean and standard deviation for all 25 anthropometric dimensions based on gender and all participants.</p

Leakage for 10 models of FFR detected by fit test and self-feeling of participants.

<p>Abbreviation : FFR, Filtering facepiece respirator.</p>*<p>Pass was defined as at least two of the three FFs are greater than 100 for fit test and no leakage for self-feeling.</p