Enzyme-level interconversion of nitrate and nitrite in the fall mixed layer of the Antarctic Ocean

In the Southern Ocean, the nitrogen (N) isotopes of organic matter and the N and oxygen (O) isotopes of nitrate (NO_3^−) have been used to investigate NO_3^− assimilation and N cycling in the summertime period of phytoplankton growth, both today and in the past. However, recent studies indicate the significance of processes in other seasons for producing the annual cycle of N isotope changes. This study explores the impact of fall conditions on the ^(15)N/^(14)N (δ^(15)N) and ^(18)O/^(16)O (δ^(18)O) of NO_3^− and nitrite (NO_2^−) in the Pacific Antarctic Zone using depth profiles from late summer/fall of 2014. In the mixed layer, the δ^(15)N and δ^(18)O of NO_3^− + NO_2^− increase roughly equally, as expected for NO_3^− assimilation; however, the δ^(15)N of NO_3^−-only (measured after NO_2− removal) increases more than does NO_3^− -only δ^(18)O. Differencing indicates that NO_2^− has an extremely low δ^(15)N, often < −70‰ versus air. These observations are consistent with the expression of an equilibrium N isotope effect between NO_3^− and NO_2^−, likely due to enzymatic NO_3^- - NO_2^− interconversion. Specifically, we propose reversibility of the nitrite oxidoreductase (NXR) enzyme of nitrite oxidizers that, having been entrained from the subsurface during late summer mixed layer deepening, are inhibited by light. Our interpretation suggests a role for NO_3^- - NO_2^− interconversion where nitrifiers are transported into environments that discourage NO_2^− oxidation. This may apply to surface regions with upwelling, such as the summertime Antarctic. It may also apply to oxygen-deficient zones, where NXR-catalyzed interconversion may explain previously reported evidence of NO_2^− oxidation

GUT theories from Calabi-Yau 4-folds with SO(10) Singularities

We consider an SO(10) GUT model from F-theory compactified on an elliptically fibered Calabi-Yau with a D5 singularity. To obtain the matter curves and the Yukawa couplings, we use a global description to resolve the singularity. We identify the vector and spinor matter representations and their Yukawa couplings and we explicitly build the G-fluxes in the global model and check the agreement with the semi-local results. As our bundle is of type SU(2k), some extra conditions need to be applied to match the fluxes.Comment: 27 page

Lectures on F-theory compactifications and model building

These lecture notes are devoted to formal and phenomenological aspects of F-theory. We begin with a pedagogical introduction to the general concepts of F-theory, covering classic topics such as the connection to Type IIB orientifolds, the geometry of elliptic fibrations and the emergence of gauge groups, matter and Yukawa couplings. As a suitable framework for the construction of compact F-theory vacua we describe a special class of Weierstrass models called Tate models, whose local properties are captured by the spectral cover construction. Armed with this technology we proceed with a survey of F-theory GUT models, aiming at an overview of basic conceptual and phenomenological aspects, in particular in connection with GUT breaking via hypercharge flux.Comment: Invited contribution to the proceedings of the CERN Winter School on Supergravity, Strings and Gauge Theory 2010, to appear in Classical and Quantum Gravity; 63 pages; v2: references added, typos correcte

On Flux Quantization in F-Theory

We study the problem of four-form flux quantization in F-theory compactifications. We prove that for smooth, elliptically fibered Calabi-Yau fourfolds with a Weierstrass representation, the flux is always integrally quantized. This implies that any possible half-integral quantization effects must come from 7-branes, i.e. from singularities of the fourfold. We subsequently analyze the quantization rule on explicit fourfolds with Sp(N) singularities, and connect our findings via Sen's limit to IIB string theory. Via direct computations we find that the four-form is half-integrally quantized whenever the corresponding 7-brane stacks wrap non-spin complex surfaces, in accordance with the perturbative Freed-Witten anomaly. Our calculations on the fourfolds are done via toric techniques, whereas in IIB we rely on Sen's tachyon condensation picture to treat bound states of branes. Finally, we give general formulae for the curvature- and flux-induced D3 tadpoles for general fourfolds with Sp(N) singularities.Comment: 46 page

Update on Streptococcus suis research and prevention in the era of antimicrobial restriction: 4th International Workshop on S. suis

Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks emerged in Asia, making this bacterium a primary health concern in this part of the globe. In pigs, S. suis disease results in decreased performance and increased mortality, which have a significant economic impact on swine production worldwide. Facing the new regulations in preventive use of antimicrobials in livestock and lack of effective vaccines, control of S. suis infections is worrisome. Increasing and sharing of knowledge on this pathogen is of utmost importance. As such, the pathogenesis and epidemiology of the infection, antimicrobial resistance, progress on diagnosis, prevention, and control were among the topics discussed during the 4th International Workshop on Streptococcus suis (held in Montreal, Canada, June 2019). This review gathers together recent findings on this important pathogen from lectures performed by lead researchers from several countries including Australia, Canada, France, Germany, Japan, Spain, Thailand, The Netherlands, UK, and USA. Finally, policies and recommendations for the manufacture, quality control, and use of inactivated autogenous vaccines are addressed to advance this important field in veterinary medicine

Unification, KK-thresholds and the top Yukawa coupling in F-theory GUTs

In a class of F-theory SU(5) GUTs the low energy chiral mass spectrum is obtained from rank one fermion mass textures with a hierarchical structure organised by U(1) symmetries embedded in the exceptional E_8 group. In these theories chiral fields reside on matter `curves' and the tree level masses are computed from integrals of overlapping wavefuctions of the particles at the triple intersection points. This calculation requires knowledge of the exact form of the wavefuctions. In this work we propose a way to obtain a reliable estimate of the various quantities which determine the strength of the Yukawa couplings. We use previous analysis of KK threshold effects to determine the (ratios of) heavy mass scales of the theory which are involved in the normalization of the wave functions. We consider similar effects from the chiral spectrum of these models and discuss possible constraints on the emerging matter content. In this approach, we find that the Yukawa couplings can be determined solely from the U(1) charges of the states in the `intersection' and the torsion which is a topological invariant quantity. We apply the results to a viable SU(5) model with minimal spectrum which satisfies all the constraints imposed by our analysis. We use renormalization group analysis to estimate the top and bottom masses and find that they are in agreement with the experimental values.Comment: 28 pages, 2 figure