Finite element analysis of mechanical properties of 2.5D angle-interlock woven composites: Part 1— Full-cell model and its validation

A new parameterized micro-structural model of 2.5D angle-interlock woven composites, named ‘full-cell model’, has been established. In order to verify the validation of finite element model (FEM) based on the full-cell model, the effective elastic properties and the mechanical response of 2.5D woven composites are presented. Additionally, the effects of fibre aggregation density and thickness on the mechanical properties are also investigated in detail. The experimental results are compared with the values of FEM based on the full-cell model and inner-cell model

(E)-2-Meth­oxy-6-(thia­zol-2-ylimino­meth­yl)phenol

The title compound, C11H10N2O2S, displays an E configuration about the C=N bond. The mean planes of the thia­zole and benzene rings make a dihedral angle of 9.32 (18)°. Intra­molecular O—H⋯N hydrogen bonds are found in the crystal structure

3-[(3-Oxo-1,3-dihydro­isobenzofuran-1-yl)amino]benzoic acid

In the title compound, C15H11NO4, the dihedral angle formed by the benzene ring and isobenzofuran ring system is 67.82 (5) Å. The crystal structure is stabilized by inter­molecular O—H⋯O and N—H⋯O hydrogen-bonding inter­actions

A Novel Method of Sentence Ordering Based on Support Vector Machine

PACLIC 23 / City University of Hong Kong / 3-5 December 200

3,3′-Oxybi[isobenzofuran-1(3H)-one]

The title compound, C16H10O5, consists of two isobenzofuran-1(3H)-one moieties which are linked by a bridging O atom. The two halves of the mol­ecule display approximate non-crystallographic mirror symmetry. The dihedral angle between the two isobenzofuran-1(3H)-one ring systems is 53.18 (6) Å. Two chiral carbon centres are observed in the compound, but their absolute configurations could not be determined. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link mol­ecules into zigzag chains along c. Additional C—H⋯O inter­actions connect adjacent chains

Octa­butyl­bis{(E)-2-[4-(2-hydroxy­benzyl­ideneamino)phen­yl]acetato}di-μ2-methoxo-di-μ3-oxido-tetra­tin(IV)

The title compound, [Sn4(C4H9)8(C15H12NO3)2(CH3O)2O2], is a centrosymmetric dimer and displays a ladder type structural motif. There are four SnIV centres which can be divided into two sorts, viz. two endocyclic and two exocyclic. The endo- and exocyclic SnIV centres are linked by bidentate deprotonated methanol and μ3-O atoms. Each exocyclic SnIV centre is also coordinated by a monodentate 2-[4-(2-hydroxy­benzyl­idene­amino)phen­yl]acetate ligand. Parts of the butyl groups were found to be disordered over two sets of sites

Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly

The intact yeast alcohol dehydrogenase (ADH) tetramer of 147 kDa was introduced into a FTICR mass spectrometer by native electrospray. Electron capture dissociation of the entire 23+ to 27+ charge state distribution produced the expected charge-reduced ions and, more unexpectedly, 39 c-type peptide fragments that identified N-terminus acetylation and the first 55 amino acids. The results are in accord with the crystal structure of yeast ADH, which shows that the C-terminus is buried at the assembly interface, whereas the N-terminus is exposed, allowing ECD to occur. This remarkable observation shows promise that a top-down approach for intact protein assemblies will be effective for characterizing their components, inferring their interfaces, and obtaining both proteomics and structural biology information in one experiment

Controllable electromechanical stability of a torsional micromirror actuator with piezoelectric composite structure under capillary force

Various types of micro/nano functional devices are being widely designed as optical switches, micro scanners, micromirrors and other core optical devices. The continuing miniaturization of the functional devices makes the size dependence of electromechanical property significant in micro/nano scale due to the sharp increase of surface interactions such as capillary force from liquid bridge, van der Waals and Casimir forces from quantum fluctuations. The surface interactions can cause the pull-in instability, adhesion between parts, and even failure of device. This work provides an active control method to avoid the pull-in instability of an electrostatically driven circular micromirror by applying voltage on a torsional piezoelectric composite structure. The influences of the three types are compared of dispersion forces on the electromechanical stability of the micromirror actuator. A comprehensive electromechanical model of a torsional piezoelectric beam was established to numerically investigate the electromechanical coupling of the micromirror. The results show that the influence of capillary force on the stability of the micromirror is as significant as van der Waals force and Casimir force. By introducing piezoelectric nanoplates into the laminated torsional structure, the micromirror stability can be controlled based on the piezoelectric effect of the torsional piezoelectric composite structure. This work can contribute to the structural optimization design and manufacture of micromirror systems.Cited as: Liu, M., Chen, Y., Cheng, W., Chen, S., Yu, T., Yang, W. Controllable electromechanical stability of a torsional micromirror actuator with piezoelectric composite structure under capillary force. Capillarity, 2022, 5(3): 51-64. https://doi.org/10.46690/capi.2022.03.0

Common human cancer genes discovered by integrated gene-expression analysis

BACKGROUND: Microarray technology enables a standardized, objective assessment of oncological diagnosis and prognosis. However, such studies are typically specific to certain cancer types, and the results have limited use due to inadequate validation in large patient cohorts. Discovery of genes commonly regulated in cancer may have an important implication in understanding the common molecular mechanism of cancer. METHODS AND FINDINGS: We described an integrated gene-expression analysis of 2,186 samples from 39 studies to identify and validate a cancer type-independent gene signature that can identify cancer patients for a wide variety of human malignancies. The commonness of gene expression in 20 types of common cancer was assessed in 20 training datasets. The discriminative power of a signature defined by these common cancer genes was evaluated in the other 19 independent datasets including novel cancer types. QRT-PCR and tissue microarray were used to validate commonly regulated genes in multiple cancer types. We identified 187 genes dysregulated in nearly all cancerous tissue samples. The 187-gene signature can robustly predict cancer versus normal status for a wide variety of human malignancies with an overall accuracy of 92.6%. We further refined our signature to 28 genes confirmed by QRT-PCR. The refined signature still achieved 80% accuracy of classifying samples from mixed cancer types. This signature performs well in the prediction of novel cancer types that were not represented in training datasets. We also identified three biological pathways including glycolysis, cell cycle checkpoint II and plk3 pathways in which most genes are systematically up-regulated in many types of cancer. CONCLUSIONS: The identified signature has captured essential transcriptional features of neoplastic transformation and progression in general. These findings will help to elucidate the common molecular mechanism of cancer, and provide new insights into cancer diagnostics, prognostics and therapy