Molecular Docking of Potential Inhibitors for Influenza H7N9

As a new strain of virus emerged in 2013, avian influenza A (H7N9) virus is a threat to the public health, due to its high lethality and pathogenicity. Furthermore, H7N9 has already generated various mutations such as neuraminidase R294K mutation which could make the anti-influenza oseltamivir less effective or ineffective. In this regard, it is urgent to develop new effective anti-H7N9 drug. In this study, we used the general H7N9 neuraminidase and oseltamivir-resistant influenza virus neuraminidase as the acceptors and employed the small molecules including quercetin, chlorogenic acid, baicalein, and oleanolic acid as the donors to perform the molecular docking for exploring the binding abilities between these small molecules and neuraminidase. The results showed that quercetin, chlorogenic acid, oleanolic acid, and baicalein present oseltamivir-comparable high binding potentials with neuraminidase. Further analyses showed that R294K mutation in neuraminidase could remarkably decrease the binding energies for oseltamivir, while other small molecules showed stable binding abilities with mutated neuraminidase. Taken together, the molecular docking studies identified four potential inhibitors for neuraminidase of H7N9, which might be effective for the drug-resistant mutants

Understanding the Eastward Shift and Intensification of the ENSO Teleconnection Over South Pacific and Antarctica Under Greenhouse Warming

The Pacific–South America (PSA) teleconnection pattern triggered by the El Niño/Southern Oscillation (ENSO) is suggested to be moving eastward and intensifying under global warming. However, the underlying mechanism is not completely understood. Previous studies have proposed that the movement of the PSA teleconnection pattern is attributable to the eastward shift of the tropical Pacific ENSO-driven rainfall anomalies in response to the projected El Niño-like sea surface temperature (SST) warming pattern. In this study, we found that with uniform warming, models will also simulate an eastward movement of the PSA teleconnection pattern, without the impact of the uneven SST warming pattern. Further investigation reveals that future changes in the climatology of the atmospheric circulation, particularly the movement of the exit region of the subtropical jet stream, can also contribute to the eastward shift of the PSA teleconnection pattern by modifying the conversion of mean kinetic energy to eddy kinetic energy

The Role of Nonlinear Energy Advection in Forming Asymmetric Structure of ENSO Teleconnections Over the North Pacific and North America

Abstract In boreal winter, the El Niño/Southern Oscillation (ENSO)‐induced Pacific‐North American (PNA) teleconnection pattern is farther westward during La Niña relative to that in El Niño, causing discernible distinct climate implications. However, there has been a lack of consensus regarding the underlying mechanism driving this asymmetric structure. This study highlights the contribution of nonlinear kinetic energy advection (nKA) to this asymmetry. The zonally symmetric responses to ENSO, specifically the anomalies in zonal mean zonal flow, generate opposing nKA patterns by advecting anomalous eddy kinetic energy in the North Pacific, which leads to the shift of the PNA teleconnection pattern. In addition to nKA, transient eddy activities responded to changes of baroclinicity help maintain the asymmetry through a feedback effect. These findings underscore the importance of considering extratropical factors, such as nonlinear energy processes and synoptic‐scale transient eddies, in understanding the mechanism responsible for the asymmetric structure of the PNA teleconnection pattern

Asymmetric impacts of El Niño and La Niña on the Pacific–North American teleconnection pattern: the role of subtropical jet stream

The asymmetric impacts of El Niño and La Niña on the Pacific–North American teleconnection pattern in boreal winter have important implications for the surface air temperature and precipitation anomalies in North America. Previous studies have shown that the varying tropical convective heating contributes to the zonal shift of the teleconnection pattern during different El Niño/Southern Oscillation phases. In this study, using reanalysis, atmospheric general circulation model (AGCM) simulations, and a linear baroclinic model, we further present that the discrepancy of the subtropical jet stream (STJ) during El Niño and La Niña also contributes to the asymmetry. The atmospheric anomalies readily extract kinetic energy and effectively develop at the exit of the STJ. During El Niño (La Niña) years, as the central-eastern tropical Pacific warms up (cools down), the meridional temperature gradient in central subtropical Pacific increases (decreases), leading to the eastward (westward) shift of the STJ. The movement of the STJ leads to the shift of the location where disturbance develops most efficiently, ultimately contributing to the asymmetry of the teleconnection pattern

Drift‐free localisation using prior cross‐source map for indoor low‐light environments

Abstract In this study, a localisation system without cumulative errors is proposed. First, depth odometry is achieved only by using the depth information from the depth camera. Then the point cloud cross‐source map registration is realised by 3D particle filtering to obtain the pose of the point cloud relative to the map. Furthermore, we fuse the odometry results with the point cloud to map registration results, so the system can operate effectively even if the map is incomplete. The effectiveness of the system for long‐term localisation, localisation in the incomplete map, and localisation in low light through multiple experiments on the self‐recorded dataset is demonstrated. Compared with other methods, the results are better than theirs and achieve high indoor localisation accuracy

Comparison of demographic characteristics and clinical characteristics among the three groups.

Comparison of demographic characteristics and clinical characteristics among the three groups.</p

A multivariate probabilistic framework for tracking the regional tropical edges: analysis of inter-annual variations and long-term trends

In the present study, a multivariate probabilistic framework is used to identify the meridional positions of regional tropical edges (RTEs), which are based on two variables: sea level pressure and precipitation minus evaporation. This new defined metric effectively captures inter-annual variability and long-term trend of the commonly adopted zonal mean tropical edge based on meridional mass stream function and near-surface winds. Besides, pronounced RTE trends are primarily located over the oceanic regions, and the terrestrial areas exhibit substantial inter-annual variability. These results are consistent among three modern reanalysis datasets. Moreover, the impacts of climate modes on RTE are investigated. The El Niño-Southern Oscillation, the Atlantic multi-decadal oscillation, and the Southern Annular Mode are important both on the inter-annual variations and long-term trends of RTE. The Pacific Decadal Oscillation is more inclined to affect long-term contribution rather than inter-annual relationship, and the Pacific–North American teleconnection, the North Atlantic Oscillation, and the Arctic oscillation highlight the inter-annual relationship with RTE in the specific regions, such as North Pacific, North Atlantic, and North Africa, respectively

Comparison of outcomes among the three groups.

PurposeTo inspect whether time management with radio frequency identification technology (RFID) reduces symptom onset-to-intravenous thrombolysis time (OTT) in acute ischemic stroke (AIS).MethodsIn the retrospective study, patients with AIS, transferred by Emergency Medical Services (EMS) to Hunan Provincial People’s Hospital between September 2019 to June 2022, divided into three groups, as traditional group, in-hospital RFID group and whole process RFID group. Baseline characteristics and time metrics were compared.ResultsAfter the whole emergency process applied with RFID time management, Door to intravenous thrombolysis time (DNT) was reduced from 125.00±43.16 min to 32.59±25.45 min (F = 121.857, pF = 10.377, pConclusionsTime management with RFID is effective in reducing OTT in AIS patients with thrombolysis treatment.</div