Beck Depression Inventory (BDI) scores before and after internship and at months 3, 6, and 12 of the internship.

<p>Beck Depression Inventory (BDI) scores before and after internship and at months 3, 6, and 12 of the internship.</p

The proportion of interns who reported phantom vibration syndrome (PVS) and phantom ringing syndrome (PRS) before and after the internship and at months 3, 6, and 12 of the internship.

<p>The proportion of interns who reported phantom vibration syndrome (PVS) and phantom ringing syndrome (PRS) before and after the internship and at months 3, 6, and 12 of the internship.</p

Beck Anxiety Inventory (BAI) scores before and after the internship and at months 3, 6, and of the internship.

<p>Beck Anxiety Inventory (BAI) scores before and after the internship and at months 3, 6, and of the internship.</p

Model of predictors for anxiety and depression scores.

<p>Key: CI, confidence interval; NS, novelty seeking; HA, harm avoidance; RD, reward dependence, according to the Tridimensional Personality Questionnaire; *significant changes from baseline (P<0.05).</p

TPQ data between borderline pattern and other pattern individuals.

*<p><i>p</i><0.05,</p>**<p><i>p</i><0.001.</p><p>RD total does not include RD2.</p><p>Borderline index  =  NS total + HA total – RD total.</p><p>TPQ, Tridimensional Personality Questionnaire; NS, novelty seeking; HA, harm avoidance; RD, reward dependence.</p

A simple linear regression model of the borderline index and differences in high frequency power of heart rate variability (HF), normalized low frequency power of heart rate variability (LF%), ratio of LF/HF (LF/HF) before and after taking methadone.

<p>The borderline index, defined by novelty seeking score + harm avoidance score – reward dependence score  =  BI score from the Tridimensional Personality Questionnaire is used as a proposed value for evaluating the severity of borderline features.</p

Demographic, psychological state and substance use behaviors compared between the borderline pattern and other patterns.

*<p><i>p</i><0.05,</p>**<p><i>p</i><0.001.</p><p>BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; BDI, Beck Depression Inventory; SOWS, Subjective Opiate Withdrawal Scale; Q score, estimated consumption amount score.</p

Predictors of HRV difference after controlling for age, BMI, exercise level, SOWS score, BDI score, current methadone dose and substance Q scores by multiple linear regression analysis.

*<p><i>p</i><0.05,</p>**<p><i>p</i><0.001.</p><p>HRV, heart rate variability; BMI, body mass index; SOWS, Subjective Opiate Withdrawal Scale; BDI, Beck Depression Inventory; Q score, estimated consumption amount score; HF, high frequency power of HRV, LF, low frequency power of HRV, LF%, normalized low frequency power of HRV.</p

Additional file 1: Table S1. of The relation between the patient health questionnaire-15 and DSM somatic diagnoses

Confirmatory factor analysis and goodness of fit statistics for the different models of PHQ-15. (DOC 32 kb