139 research outputs found

    Western blot analysis of BDNF and GDNF in human milk.

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    <p><b>A:</b> BDNF band at approximately 27 kDa. <b>B:</b> GDNF band at approximately 20 kDa.</p

    1‑Methyl Boratabenzene Yttrium Alkyl: A Highly Active Catalyst for Dehydrocoupling of Me<sub>2</sub>NH·BH<sub>3</sub>

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    Catalytic activity of rare-earth metal complexes for dehydrocoupling of Me<sub>2</sub>NH·BH<sub>3</sub> is deeply ligand- and metal ion-dependent, and 1-methyl boratabenzene yttrium alkyl shows very high activity for the reaction (TOF > 1000 h<sup>–1</sup>). The transformation of Me<sub>2</sub>NH·BH<sub>3</sub> into [Me<sub>2</sub>N–BH<sub>2</sub>]<sub>2</sub> proceeds through an intermediate Me<sub>2</sub>NH–BH<sub>2</sub>–NMe<sub>2</sub>–BH<sub>3</sub>

    New <sup>1</sup>H NMR-Based Technique To Determine Epoxide Concentrations in Oxidized Oil

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    A new method to determine epoxide concentrations in oxidized oils was developed and validated using <sup>1</sup>H NMR. Epoxides derived from lipid oxidation gave signals between 2.90 and 3.24 ppm, well separated from the signals of other lipid oxidation products. To calibrate, soybean oils with a range of epoxide concentrations were synthesized and analyzed using <sup>1</sup>H NMR by taking the <i>sn</i>-1,3 glycerol protons (4.18, 4.33 ppm) as internal references. The <sup>1</sup>H NMR signals were compared to the epoxide content determined by titration with hydrogen bromide (HBr)–acetic acid solution. As expected, the signal response increased with concentration linearly (<i>R</i><sup>2</sup> = 99.96%), and validation of the method gave results comparable to those of the HBr method. A study of the oxidative stability of soybean oil was performed by applying this method to monitor epoxides during thermal lipid oxidation. The epoxide content increased over time and showed a different trend compared to peroxide value (PV). A phenomenological model was suggested to model epoxides derived from lipid oxidation

    Cytokines in human milk from Chinese women during day 3, 10, 30, and 90 after parturition (n = 24).

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    <p>Cytokines in human milk from Chinese women during day 3, 10, 30, and 90 after parturition (n = 24).</p

    Interaction of Cobalt Nanoparticles with Oxygen- and Nitrogen-Functionalized Carbon Nanotubes and Impact on Nitrobenzene Hydrogenation Catalysis

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    The type and the amount of functional groups on the surface of carbon nanotubes (CNTs) were tuned to improve the activity of supported Co nanoparticles in hydrogenation catalysis. Surface nitrogen species on CNTs significantly promoted the decomposition of the cobalt precursor and the reduction of cobalt oxide, and improved the resistance of metallic Co against oxidation in ambient atmosphere. In the selective hydrogenation of nitrobenzene in the gas phase, Co supported on CNTs with the highest surface nitrogen content showed the highest activity, which is ascribed to the higher reducibility and the lower oxidation state of the Co nanoparticles under reaction conditions. For Co nanoparticles supported on CNTs with a smaller amount of surface nitrogen groups, a repeated reduction at 350 °C was essential to achieve a comparable high catalytic activity reaching 90% conversion at 250 °C, pointing to the importance of nitrogen species for the supported Co nanoparticles in nitrobenzene hydrogenation

    Positive association between levels of S100B and BDNF in human milk.

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    <p>The solid line represents the predicted regression line determined from repeated-measures analysis of S100B and BDNF concentrations 3 month after parturition. n = 24, P = 0.037<0.05.</p

    S100B levels in human milk were closely correlated with BMI.

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    <p>The solid line represents the predicted regression line determined from measures analysis of human milk collected 3 days after birth. Pearson correlation coefficient (<i>r</i>) was 0.335. <i>P</i><0.05. n = 42.</p

    Bismuth-Induced Inactivation of Ferric Uptake Regulator from <i>Helicobacter pylori</i>

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    Ferric uptake regulator (Fur) of <i>Helicobacter pylori</i> is a global regulator that is important for bacterial colonization and survival within the gastric mucosa. <i>H. pylori</i> Fur (<i>Hp</i>Fur) is unique in its ability to regulate gene expression in both metal-bound (holo-Fur) and metal-free (apo-Fur) forms. Bismuth-based drugs are widely used for the treatment of <i>H. pylori</i> infection. However, the mechanism of action of bismuth drug was not fully understood. Recently, it has been reported that bismuth drugs could interfere with the bacterial ferric uptake pathway and inhibit bacterial growth, implying intrinsic correlation between bismuth drug and bacterial iron metabolism. Herein, we demonstrate that Bi­(III) binds to <i>Hp</i>Fur protein specifically at the physiologically important S1 site, which further leads to protein oligomerization and loss of DNA binding capability. The targeting of <i>Hp</i>Fur by bismuth drugs significantly reduced transcription levels of its regulated genes, which are crucial for bacterial physiology and metabolism. Our studies present direct evidence that perturbation of iron metabolism in <i>H. pylori</i> by bismuth might serve as one of the mechanisms for the antimicrobial activity of bismuth drugs

    Reusable Hydrophilic–Superhydrophobic Patterned Weft Backed Woven Fabric for High-Efficiency Water-Harvesting Application

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    Here we report a hydrophilic–superhydrophobic patterned surface, which was fabricated via a readily weaving method to mimic the hybrid wettable areas arrangements on the back of Stenocara beetles. The fabric exhibited excellent water-harvesting rate (WHR) of 1267.2 mg h<sup>–1</sup> cm<sup>–2</sup>. Besides, the fabric could be recycled for 10 times while the WHR stayed almost invariant. This work offers a very feasible and novel tool to achieve mass production of water-harvesting materials, providing novel ideas to bridge traditional textile industry with environmental conservation in the future
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