301 research outputs found
Paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro
Aim: To evaluate the effects of paclitaxel-octreotide conjugates on the growth of cultured non-small cell lung cancer cells. Methods: RT-PCR was performed to detect mRNA for the subtypes of the human somatostatin receptor (SSTR) using specific primers. MTT-based cytotoxicity assay was used to evaluate the cell viability after treatment with paclitaxel and the conjugates. Cell cycle perturbations were determined using a Fluorescence-Activated Cell Sorter. Results: Non-small cell lung cancer A549 and Calu-6 cells expressed mRNA for SSTR2 and SSTR5. Paclitaxel and the conjugates effectively inhibited the growth of A549 and Calu-6 cells in a concentration- and time-dependent manner. In SSTR-negative fibroblasts, the conjugates were less cytotoxic than paclitaxel. The conjugates and paclitaxel could induce the increase of G2/M phase ratio in A549 cells. Conclusion: The paclitaxel-octreotide conjugates can be used as selective-targeted chemotherapeutic agents for treating non-small cell lung cancer.Π¦Π΅Π»Ρ: ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π»Π°-ΠΎΠΊΡΡΠ΅ΠΎΡΠΈΠ΄Π° Π½Π° ΡΠΎΡΡ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°
Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ΅ΡΠΎΠ΄Ρ: Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΌΠ ΠΠ ΠΏΠΎΠ΄ΡΠΈΠΏΠΎΠ² ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΡΠΎΠΌΠ°ΡΠΎΡΡΠ°ΡΠΈΠ½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (SSTR) ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ ΠT-ΠΠ¦Π .
ΠΠ½Π°Π»ΠΈΠ· ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ Π² ΠΠ’Π’-ΡΠ΅ΡΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ ΠΈΡ
ΠΈΠ½ΠΊΡΠ±Π°ΡΠΈΠΈ Ρ ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π»ΠΎΠΌ
ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°ΠΌΠΈ. ΠΠ°ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ FACS β ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ΅ΡΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ:
ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π»ΠΈΠ½ΠΈΠΈ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ A549 ΠΈ Calu-6 ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡ SSTR2 ΠΈ SSTR5 ΠΌΠ ΠΠ.
ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π΄ΠΎΠ·ΠΎ- ΠΈ Π²ΡΠ΅ΠΌΡΠ·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠ³Π½Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΡΠ° ΠΊΠ»Π΅ΡΠΎΠΊ A549 ΠΈ Calu-6 ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π»ΠΎΠΌ ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°ΠΌΠΈ.
ΠΠ»Ρ SSTR-Π½Π΅Π³Π°ΡΠΈΠ²Π½ΡΡ
ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ² ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ ΠΌΠ΅Π½Π΅Π΅ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½Ρ, ΡΠ΅ΠΌ ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π». ΠΠΎΠ½ΡΡΠ³Π°ΡΡ ΠΈ ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π» ΠΌΠΎΠ³ΡΡ
ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΡΠ°Π· G2
/M Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
A549. ΠΡΠ²ΠΎΠ΄Ρ: ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ ΠΏΠ°ΠΊΠ»ΠΈΡΠ°ΠΊΡΠ΅Π»-ΠΎΠΊΡΡΠ΅ΠΎΡΠΈΠ΄Π° ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΊΠ°ΠΊ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π³Π΅Π½ΡΡ Π΄Π»Ρ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
Cosmological Constraints on the Sign-Changeable Interactions
Recently, Cai and Su [Phys. Rev. D {\bf 81}, 103514 (2010)] found that the
sign of interaction in the dark sector changed in the approximate redshift
range of 0.45\,\lsim\, z\,\lsim\, 0.9, by using a model-independent method to
deal with the observational data. In fact, this result raises a remarkable
problem, since most of the familiar interactions cannot change their signs in
the whole cosmic history. Motivated by the work of Cai and Su, we have proposed
a new type of interaction in a previous work [H. Wei, Nucl. Phys. B {\bf 845},
381 (2011)]. The key ingredient is the deceleration parameter in the
interaction , and hence the interaction can change its sign when our
universe changes from deceleration () to acceleration (). In the
present work, we consider the cosmological constraints on this new type of
sign-changeable interactions, by using the latest observational data. We find
that the cosmological constraints on the model parameters are fairly tight. In
particular, the key parameter can be constrained to a narrow range.Comment: 15 pages, 1 table, 8 figures, revtex4; v2: published versio
Signal differenceβbased deadband control for networked control systems with variable sampling intervals
Running coupling: Does the coupling between dark energy and dark matter change sign during the cosmological evolution?
In this paper we put forward a running coupling scenario for describing the
interaction between dark energy and dark matter. The dark sector interaction in
our scenario is free of the assumption that the interaction term is
proportional to the Hubble expansion rate and the energy densities of dark
sectors. We only use a time-variable coupling (with the scale factor
of the universe) to characterize the interaction . We propose a
parametrization form for the running coupling in which the
early-time coupling is given by a constant , while today the coupling is
given by another constant, . For investigating the feature of the running
coupling, we employ three dark energy models, namely, the cosmological constant
model (), the constant model (), and the time-dependent
model (). We constrain the models with the current
observational data, including the type Ia supernova, the baryon acoustic
oscillation, the cosmic microwave background, the Hubble expansion rate, and
the X-ray gas mass fraction data. The fitting results indicate that a
time-varying vacuum scenario is favored, in which the coupling crosses
the noninteracting line () during the cosmological evolution and the sign
changes from negative to positive. The crossing of the noninteracting line
happens at around , and the crossing behavior is favored at about
1 confidence level. Our work implies that we should pay more attention
to the time-varying vacuum model and seriously consider the phenomenological
construction of a sign-changeable or oscillatory interaction between dark
sectors.Comment: 8 pages, 5 figures; refs added; to appear in EPJ
Search for the Rare Decays J/Psi --> Ds- e+ nu_e, J/Psi --> D- e+ nu_e, and J/Psi --> D0bar e+ e-
We report on a search for the decays J/Psi --> Ds- e+ nu_e + c.c., J/Psi -->
D- e+ nu_e + c.c., and J/Psi --> D0bar e+ e- + c.c. in a sample of 5.8 * 10^7
J/Psi events collected with the BESII detector at the BEPC. No excess of signal
above background is observed, and 90% confidence level upper limits on the
branching fractions are set: B(J/Psi --> Ds- e+ nu_e + c.c.)<4.8*10^-5, B(J/Psi
--> D- e+ nu_e + c.c.) D0bar e+ e- + c.c.)<1.1*10^-5Comment: 10 pages, 4 figure
Study of J/psi decays to Lambda Lambdabar and Sigma0 Sigma0bar
The branching ratios and Angular distributions for J/psi decays to Lambda
Lambdabar and Sigma0 Sigma0bar are measured using BESII 58 million J/psi.Comment: 11 pages, 5 figure
Direct Measurements of the Branching Fractions for and and Determinations of the Form Factors and
The absolute branching fractions for the decays and
are determined using singly
tagged sample from the data collected around 3.773 GeV with the
BES-II detector at the BEPC. In the system recoiling against the singly tagged
meson, events for and events for decays are observed. Those yield
the absolute branching fractions to be and . The
vector form factors are determined to be
and . The ratio of the two form
factors is measured to be .Comment: 6 pages, 5 figure
Measurements of J/psi Decays into 2(pi+pi-)eta and 3(pi+pi-)eta
Based on a sample of 5.8X 10^7 J/psi events taken with the BESII detector,
the branching fractions of J/psi--> 2(pi+pi-)eta and J/psi-->3(pi+pi-)eta are
measured for the first time to be (2.26+-0.08+-0.27)X10^{-3} and
(7.24+-0.96+-1.11)X10^{-4}, respectively.Comment: 11 pages, 6 figure
BESII Detector Simulation
A Monte Carlo program based on Geant3 has been developed for BESII detector
simulation. The organization of the program is outlined, and the digitization
procedure for simulating the response of various sub-detectors is described.
Comparisons with data show that the performance of the program is generally
satisfactory.Comment: 17 pages, 14 figures, uses elsart.cls, to be submitted to NIM
Measurement of branching fractions for the inclusive Cabibbo-favored ~K*0(892) and Cabibbo-suppressed K*0(892) decays of neutral and charged D mesons
The branching fractions for the inclusive Cabibbo-favored ~K*0 and
Cabibbo-suppressed K*0 decays of D mesons are measured based on a data sample
of 33 pb-1 collected at and around the center-of-mass energy of 3.773 GeV with
the BES-II detector at the BEPC collider. The branching fractions for the
decays D+(0) -> ~K*0(892)X and D0 -> K*0(892)X are determined to be BF(D0 ->
\~K*0X) = (8.7 +/- 4.0 +/- 1.2)%, BF(D+ -> ~K*0X) = (23.2 +/- 4.5 +/- 3.0)% and
BF(D0 -> K*0X) = (2.8 +/- 1.2 +/- 0.4)%. An upper limit on the branching
fraction at 90% C.L. for the decay D+ -> K*0(892)X is set to be BF(D+ -> K*0X)
< 6.6%
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