Distribution of CATs, CURB-65 and PMEWS scores according to outcome measures (Level 2/3 admission, mortality, combined measure of severe outcomes) in children (<16 years).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Predictive values of CATs, CURB-65 and PMEWS scores for predicting severe outcomes in adults (≥16 years, n = 1040).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Distribution of CATs, CURB-65 and PMEWS scores according to outcome measures (Level 2/3 admission, mortality, combined measure of severe outcomes) in adults (≥16 years).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Multivariable analyses of CAT criteria as independent predictors of outcomes in children (<16 years), forward stepwise regression.

<p>Values are adjusted odds ratios (95% confidence intervals), significant values in bold and p values in italic. Each predictor variable (CAT criterion) in model adjusted for other criteria in the multivariable model remaining following forward stepwise regression (significance level for addition to the model p≤0.05); * criteria excluded from the final model. X Not calculated as this criterion typically directs the outcome (use of supplemental oxygen).</p

The predictive values of CATs, CURB-65 and PMEWS for predicting severe outcomes in adults and children with pandemic influenza.

<p>ROC curves comparing the predictive value of CATs (black solid line), CURB-65 (grey dash line) and PMEWS (black dash line) in relation to Level 2/3 admissions (upper panels), mortality (middle panels) and combined severe outcomes (lower panels) in adults (left panels, age ≥16 years, n = 1040) and children (right panels, age<16 years, n = 480).</p

Multivariable analyses of CAT criteria as independent predictors of outcomes in adults (≥16 years), forward stepwise regression.

<p>Values are adjusted odds ratios (95% confidence intervals), significant values in bold and p values in italic. Each predictor variable (CAT criterion) in model adjusted for other criteria in the multivariable model remaining following forward stepwise regression (significance level for addition to the model p≤0.05); X Not calculated as this criterion typically directs the outcome (use of supplemental oxygen).</p

Predictive values of CATs, CURB-65 and PMEWS scores for predicting severe outcomes in children (<16 years, n = 480).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Demographic characteristics of 1520 UK patients hospitalised with pandemic H1N1 infection during the 2009/10 pandemic (The FLU-CIN Cohort) compared with source population and pre-pandemic hospital data on acute respiratory infection admissions.

<p>Data are numbers (%), unless otherwise indicated.</p>†<p>Census 2001 Data for comparison of sex (KS01 tables) were obtained from the Office for National Statistics (ONS) (<a href="http://www.statistics.gov.uk" target="_blank">www.statistics.gov.uk</a>). ^‡Demographic data on age distribution based on 2009 mid-year population estimates, ONS.</p>‡‡<p>Ethnicity data from ONS (Census 2001 data, 2001 data from the General Register Office for Scotland and Northern Ireland Statistics and Research Agency). *Hospital Episodes Statistics (HES) data: primary discharge codes relating to possible influenza admissions (J06, J10, J11, J13–22) were considered for the pre-pandemic influenza active period Nov 2008-Mar 2009.</p

CAT criteria as independent predictors of use of oxygen, mechanical ventilation and severe outcomes in adults.

<p>Multivariable analyses by forward stepwise regression of CAT criteria as independent predictors of use of oxygen [upper panel], mechanical ventilation [middle panel] and combined severe outcomes (level 2/3 admission or death)[lower panel] in adults (≥16 years).</p

Unadjusted analysis investigating the association between meeting CAT criteria and outcome measures in adults (≥16 years).

<p>Values are unadjusted odds ratios (95% confidence intervals), significant values (p<0.05) in bold and p values in italic. X Not calculated as this criterion typically directs the outcome (use of supplemental oxygen).</p