Data class-specific all-optical transformations and encryption

Diffractive optical networks provide rich opportunities for visual computing tasks since the spatial information of a scene can be directly accessed by a diffractive processor without requiring any digital pre-processing steps. Here we present data class-specific transformations all-optically performed between the input and output fields-of-view (FOVs) of a diffractive network. The visual information of the objects is encoded into the amplitude (A), phase (P), or intensity (I) of the optical field at the input, which is all-optically processed by a data class-specific diffractive network. At the output, an image sensor-array directly measures the transformed patterns, all-optically encrypted using the transformation matrices pre-assigned to different data classes, i.e., a separate matrix for each data class. The original input images can be recovered by applying the correct decryption key (the inverse transformation) corresponding to the matching data class, while applying any other key will lead to loss of information. The class-specificity of these all-optical diffractive transformations creates opportunities where different keys can be distributed to different users; each user can only decode the acquired images of only one data class, serving multiple users in an all-optically encrypted manner. We numerically demonstrated all-optical class-specific transformations covering A-->A, I-->I, and P-->I transformations using various image datasets. We also experimentally validated the feasibility of this framework by fabricating a class-specific I-->I transformation diffractive network using two-photon polymerization and successfully tested it at 1550 nm wavelength. Data class-specific all-optical transformations provide a fast and energy-efficient method for image and data encryption, enhancing data security and privacy.Comment: 27 Pages, 9 Figures, 1 Tabl

Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine

The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific transcription factors was able to turn back the developmental clock of somatic cells into an embryonic-like state. The resulting iPSCs carry the developmental potential of human embryonic stem cells (hESC) without the embryo and have been heralded as a powerful tool to study development and disease. This technology has made it possible for the first time for researchers to transform end-differentiated cells from a particular individual into another cell type that remains specific to that individual, paving the way for novel methods of in vitro disease modelling and therapeutic applications. This paper reviews some of the key areas in cardiovascular medicine in which iPSC technology has been applied and discusses the future directions and ongoing challenges ahead in this exciting field

Speculative Decoding: Exploiting Speculative Execution for Accelerating Seq2seq Generation

We propose Speculative Decoding (SpecDec), for the first time ever, to formally study exploiting the idea of speculative execution to accelerate autoregressive (AR) decoding. Speculative Decoding has two innovations: Spec-Drafter -- an independent model specially optimized for efficient and accurate drafting -- and Spec-Verification -- a reliable method for verifying the drafted tokens efficiently in the decoding paradigm. Experimental results on various seq2seq tasks including machine translation and abstractive summarization show our approach can achieve around $5\times$ speedup for the popular Transformer architectures with comparable generation quality to beam search decoding, refreshing the impression that the draft-then-verify paradigm introduces only $1.4\times$$\sim$$2\times$ speedup. In addition to the remarkable speedup, we also demonstrate 3 additional advantages of SpecDec, revealing its practical value for accelerating generative models in real-world applications. Our models and codes are available at https://github.com/hemingkx/SpecDec.Comment: $\textbf{v1-v4}$ (Early 2022): Initially announced with the name "Generalized Aggressive Decoding"; $\textbf{v5}$ (September 2022): Renamed to "Speculative Decoding" as the ICLR'23 submission (https://openreview.net/pdf?id=H-VlwsYvVi), marking $\textbf{the first time}$ "Speculative Decoding" has been publicly proposed. $\textbf{v6}$: EMNLP'23 Findings camera read

A Corrugated Diaphragm-Based Fabry-Perot Ultrasonic Sensor by Two-Photon 3D Printing

peer reviewedA polymer corrugated diaphragm-based fiber-optic Fabry-Perot (FP) interferometer is proposed as an ultrasonic sensor and directly fabricated on an optical fiber tip by direct laser writing via two-photon polymerization. The structure of the corrugated diaphragm is optimized, and the mechanical properties are investigated numerically. The experimental results show that the proposed device has a resonant frequency of 150 kHz and an enhanced mechanical sensitivity of 367.73nm/kPa@100 kHz, and a low noise equivalent level of 1.92 mPa/Hz1/2@100 kHz. The sensitivity is much higher that of FP devices with uniform diaphragm, demonstrating that the designed sensor is capable of detecting weak ultrasonic waves

3D printed Fabry-Perot acoustic probe with a glass horn tube

peer reviewedSensing an incoming acoustic signal is typically associated with absorbing the energy, perturbing the measurement and therefore causing a deformation of the sensing elements, which is mainly related to the acoustic wave pressure. Here, we demonstrated a fiber-tip based Fabry-Perot (FP) acoustic probe sensor, which was directly printed on an optical fiber tip by a two-photon 3D printing technique and assembled by a glass horn structure, which can improve the sensitivity. It showed that the sensor has a −3 dB bandwidth of 366.05 kHz at the first resonant frequency of 467.84 kHz. A low noise-limited minimum detectable pressure level of 4.71 mPa/Hz1/2@100 kHz is obtained. Due to the acoustic wave focusing property of the horn structure, the detected signal intensity can be amplified by 4 times as the sensor located at the bottom position. It demonstrates that 3D printed micro acoustic devices could be used for weak acoustic wave detection in the applications of partial discharge, photoacoustic imaging and non-destructive detection

Quantitative analysis of systemic perfusion and cerebral blood flow in the modeling of aging and orthostatic hypotension

Introduction: Orthostatic hypotension (OH) is common among the older population. The mechanism hypothesized by OH as a risk factor for cognitive decline and dementia is repeated transient cerebral blood flow deficiency. However, to our knowledge, quantitative evaluation of cardiac output and cerebral blood flow due to acute blood pressure changes resulting from postural changes is rare.Methods: We report a new fluid-structure interaction model to analyze the quantitative relationship of cerebral blood flow during OH episodes. A device was designed to simulate the aging of blood vessels.Results and Discussion: The results showed that OH was associated with decreased transient cerebral blood flow. With the arterial aging, lesions, the reduction in cerebral blood flow is accelerated. These findings suggest that systolic blood pressure regulation is more strongly associated with cerebral blood flow than diastolic blood pressure, and that more severe OH carries a greater risk of dementia. The model containing multiple risk factors could apply to analyze and predict for individual patients. This study could explain the hypothesis that transient cerebral blood flow deficiency in recurrent OH is associated with cognitive decline and dementia

Engineered zero-dispersion microcombs using CMOS-ready photonics

Normal group velocity dispersion (GVD) microcombs offer high comb line power and high pumping efficiency compared to bright pulse microcombs. The recent demonstration of normal GVD microcombs using CMOS-foundry-produced microresonators is an important step towards scalable production. However, the chromatic dispersion of CMOS devices is large and impairs generation of broadband microcombs. Here, we report the development of a microresonator in which GVD is reduced due to a couple-ring resonator configuration. Operating in the turnkey self-injection-locking mode, the resonator is hybridly integrated with a semiconductor laser pump to produce high-power-efficiency combs spanning a bandwidth of 9.9 nm (1.22 THz) centered at 1560 nm, corresponding to 62 comb lines. Fast, linear optical sampling of the comb waveform is used to observe the rich set of near-zero GVD comb behaviors, including soliton molecules, switching waves (platicons) and their hybrids. Tuning of the 20 GHz repetition rate by electrical actuation enables servo locking to a microwave reference, which simultaneously stabilizes the comb repetition rate, offset frequency and temporal waveform. This hybridly integrated system could be used in coherent communications or for ultra-stable microwave signal generation by two-point optical frequency division.Comment: 8 pages, 4 figure

Point-by-Point Induced High Birefringence Polymer Optical Fiber Bragg Grating for Strain Measurement

peer reviewedIn this paper, the first- and fourth-order fiber Bragg grating (FBG)-based axial strain sensors are proposed. The FBGs are inscribed in step-index polymer optical fibers (POFs) (TOPAS core and ZEONEX cladding) via the point-by-point (PbP) direct-writing technique. A first-order FBG with a single peak is obtained with a pulse fluence of 7.16 J/cm2, showing a strain sensitivity of 1.17 pm/με. After that, a fourth-order FBG with seven peaks is obtained with a pulse fluence of 1.81 J/cm2 with a strain sensitivity between 1.249 pm/με and 1.296 pm/με. With a higher fluence of 2.41 J/cm2, a second fourth-order FBG with five peaks is obtained, each of which is split into two peaks due to high birefringence (Hi-Bi) of ~5.4 × 10−4. The two split peaks present a strain sensitivity of ~1.44 pm/με and ~1.55 pm/με, respectively. The peak difference corresponding to Hi-Bi presents a strain sensitivity of ~0.11 pm/με and could potentially be used for simultaneous dual-parameter measurement, such as temperature and strain

The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function

High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)-rs2272996-in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase. In the present study, we first replicated the association of rs2272996 and BP traits with a total sample size of nearly 30,000 individuals from the Continental Origins and Genetic Epidemiology Network (COGENT) of African Americans (P=0.01). This association was further validated using patient plasma samples; we observed that the N131S mutation is associated with significantly lower plasma vanin-1 protein levels. We observed that the N131S vanin-1 is subjected to rapid endoplasmic reticulum-associated degradation (ERAD) as the underlying mechanism for its reduction. Using HEK293 cells stably expressing vanin-1 variants, we showed that N131S vanin-1 was degraded significantly faster than wild type (WT) vanin-1. Consequently, there were only minimal quantities of variant vanin-1 present on the plasma membrane and greatly reduced pantetheinase activity. Application of MG-132, a proteasome inhibitor, resulted in accumulation of ubiquitinated variant protein. A further experiment demonstrated that atenolol and diltiazem, two current drugs for treating hypertension, reduce the vanin-1 protein level. Our study provides strong biological evidence for the association of the identified SNP with BP and suggests that vanin-1 misfolding and degradation are the underlying molecular mechanism

Expression profiling of ALOG family genes during inflorescence development and abiotic stress responses in rice (Oryza sativa L.)

The ALOG (Arabidopsis LSH1 and Oryza G1) family proteins, namely, DUF640 domain-containing proteins, have been reported to function as transcription factors in various plants. However, the understanding of the response and function of ALOG family genes during reproductive development and under abiotic stress is still largely limited. In this study, we comprehensively analyzed the structural characteristics of ALOG family proteins and their expression profiles during inflorescence development and under abiotic stress in rice. The results showed that OsG1/OsG1L1/2/3/4/5/6/7/8/9 all had four conserved helical structures and an inserted Zinc-Ribbon (ZnR), the other four proteins OsG1L10/11/12/13 lacked complete Helix-1 and Helix-2. In the ALOG gene promoters, there were abundant cis-acting elements, including ABA, MeJA, and drought-responsive elements. Most ALOG genes show a decrease in expression levels within 24 h under ABA and drought treatments, while OsG1L2 expression levels show an upregulated trend under ABA and drought treatments. The expression analysis at different stages of inflorescence development indicated that OsG1L1/2/3/8/11 were mainly expressed in the P1 stage; in the P4 stage, OsG1/OsG1L4/5/9/12 had a higher expression level. These results lay a good foundation for further studying the expression of rice ALOG family genes under abiotic stresses, and provide important experimental support for their functional research