Fine-grained Text and Image Guided Point Cloud Completion with CLIP Model

This paper focuses on the recently popular task of point cloud completion guided by multimodal information. Although existing methods have achieved excellent performance by fusing auxiliary images, there are still some deficiencies, including the poor generalization ability of the model and insufficient fine-grained semantic information for extracted features. In this work, we propose a novel multimodal fusion network for point cloud completion, which can simultaneously fuse visual and textual information to predict the semantic and geometric characteristics of incomplete shapes effectively. Specifically, to overcome the lack of prior information caused by the small-scale dataset, we employ a pre-trained vision-language model that is trained with a large amount of image-text pairs. Therefore, the textual and visual encoders of this large-scale model have stronger generalization ability. Then, we propose a multi-stage feature fusion strategy to fuse the textual and visual features into the backbone network progressively. Meanwhile, to further explore the effectiveness of fine-grained text descriptions for point cloud completion, we also build a text corpus with fine-grained descriptions, which can provide richer geometric details for 3D shapes. The rich text descriptions can be used for training and evaluating our network. Extensive quantitative and qualitative experiments demonstrate the superior performance of our method compared to state-of-the-art point cloud completion networks

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (Aβ)] and neurofibrillary tangles (aggregates of tau). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than Aβ plaques. Oxidative stress is a prominent early event in the pathogenesis of AD and is therefore believed to contribute to tau hyperphosphorylation. Several studies have shown that the autophagic pathway in neurons is important under physiological and pathological conditions. Therefore, this pathway plays a crucial role for the degradation of endogenous soluble tau. However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains unclear. Here, we review the latest progress in AD, with a special emphasis on oxidative stress, tau hyperphosphorylation, and autophagy. We also discuss the relationship of these three factors in AD

Impacts of Freshwater and Seawater Mixing on the Production and Decay of Virioplankton in a Subtropical Estuary

Abstract(#br)Virioplankton is an important component of the aquatic ecosystem and plays multiple ecological and biogeochemical roles. Although the spatial and temporal distributions and dynamics of virioplankton have been well investigated in riverine and marine environments, little is known about the dynamics and environmental controlling mechanisms of virioplankton in estuaries. In this study, viral abundance, production and decay were examined in the Pearl River Estuary (PRE), one of the largest estuaries in China. The influences of freshwater and seawater mixing on viral ecological dynamics were evaluated with several cross-transplant experiments. In PRE, viral abundance, production and decay rates varied from 2.72 ± 0.09 to 27.5 ± 1.07 × 10 6 viruses ml −1 , 7.98 ± 2.33 to 16.27 ±..

Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

<p>Abstract</p> <p>Background</p> <p>Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development of an MDR phenotype in cancer cells. One of the most studied mechanisms is the overexpression of P-glycoprotein (P-gp), which is a product of the <it>MDR1 </it>gene. Tumor cells often acquire the drug-resistance phenotype due to upregulation of the <it>MDR1 </it>gene. Overexpression of <it>MDR1 </it>gene has often been reported in primary gastric adenocarcinoma.</p> <p>Methods</p> <p>This study investigated the role of p38-MAPK signal pathway in vincristine-resistant SGC7901/VCR cells. P-gp and MDR1 RNA were detected by Western blot analysis and RT-PCR amplification. Mitgen-activated protein kinases and function of P-gp were demonstrated by Western blot and FACS Aria cytometer analysis. Ap-1 activity and cell apoptosis were detected by Dual-Luciferase Reporter Assay and annexin V-PI dual staining.</p> <p>Results</p> <p>The vincristine-resistant SGC7901/VCR cells with increased expression of the multidrug-resistance 1 (<it>MDR1</it>) gene were resistant to P-gp-related drug and P-gp-unrelated drugs. Constitutive increases of phosphorylated p38-MAPK and AP-1 activities were also found in the drug-resistant cells. Inhibition of p38-MAPK by SB202190 reduced activator protein-1 (AP-1) activity and <it>MDR1 </it>expression levels and increased the sensitivity of SGC7901/VCR cells to chemotherapy.</p> <p>Conclusion</p> <p>Activation of the p38-MAPK pathway might be responsible for the modulation of P-glycoprotein-mediated and P-glycoprotein-unmediated multidrug resistance in the SGC7901/VCR cell line.</p

Spatiotemporal patterns and driving mechanism of tourism ecological security in Guangxi, China

Tourism ecological security (TES) is an important index reflecting the sustainable development of the regional economy. The construction of the China and ASEAN Free Trade Area has increased the total tourist consumption of Guangxi province by 36.48%. Unfortunately, overconsumption of resources, air pollution, disturbance of indigenous life, and other environmental degradation problems emerged due to the significant increase in tourists. Measuring the resilience of the tourism ecosystem is an urgent need to promote the high-quality development of tourism in Guangxi. To explore the dynamic changes in TES and its driving mechanism, the DPSIR (driver–pressure–state–impact–response) model for the tourism ecosystem was developed. The dynamic changes in TES and its driving mechanism from 2010 to 2019 were analyzed using fuzzy matter-element analysis, Markov chains, Geodetector, and other methods. The results show that: (1) the TES value increased steadily by 72.73%; the improvement speed was Northeast &gt; Southwest &gt; Southeast &gt; Northwest; (2) TES was negatively correlated with location, 14 cities developed independently; (3) the TES has a smaller probability to shift the lower level; (4) urbanization, water consumption, green area, tourism revenue, and the number of students in colleges had significant effects on TES. Four policies were proposed to improve TES: (1) developing forest tourism; (2) implementing greening projects in abandoned mining areas; (3) increasing tourism technical personnel; and (4) reducing clearance time for inbound tourists