3 research outputs found
Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair
Chronic diabetic wounds have become a major healthcare
challenge
worldwide. Improper treatment may lead to serious complications. Current
treatment methods including biological and physical methods and skin
grafting have limitations and disadvantages, such as poor efficacy,
inconvenience of use, and high cost. Therefore, developing a more
effective and feasible treatment is of great significance for the
repair of chronic diabetic wounds. Hydrogels can be designed to serve
multiple functions to promote the repair of chronic diabetic wounds.
Furthermore, 3D bioprinting enables hydrogel customization to fit
chronic diabetic wounds, thus facilitating the healing process. This
paper reports a study of 3D printing of a collagen–hyaluronic
acid composite hydrogels with application for chronic diabetic wound
repair. In situ printed hydrogels were developed by a macromolecular
crosslinking network using methacrylated recombinant human collagen
(RHCMA) and methacrylated hyaluronic acid (HAMA), both of which can
respond to ultraviolet (UV) irradiation. The hydrogels were also loaded
with silver nanoclusters (AgNCs) with ultra-small-size nanoparticles,
which have the advantages of deep penetration ability and broad-spectrum
high-efficiency antibacterial properties. The results of this study
show that the developed RHCMA, HAMA, and AgNCs (RHAg) composite hydrogels
present good UV responsiveness, porosity, mechanical properties, printability,
and biocompatibility, all of which are beneficial to wound healing.
The results of this study further show that the developed RHAg hydrogels
not only effectively inhibited Staphylococcus aureus and Pseudomonas aeruginosa but also
promoted the proliferation and migration of fibroblasts in vitro and
tissue regeneration and collagen deposition in vivo, thus producing
a desirable wound repair effect and can be used as an effective functional
biomaterial to promote chronic diabetic wound repair