Response of 222 Thai patients with various medical conditions to EuroQol 5D instrument, August to October 2009.

<p>TB_TX, TB patients receiving TB treatment; MDR_TX, MDR-TB patients receiving MDR-TB treatment; _anyTB_C, patients who had been successfully treated for TB or MDR-TB for ≥6 months; _anyHIV, HIV-infected patients at any stage; TB_TX/HIV, HIV-infected TB patients receiving TB treatment; _anyTB_C/HIV, HIV-infected patients who had been successfully treated for TB or MDR-TB for ≥6 months.</p

Multivariate tobit regression analysis examining determinants of health utility of 222 Thai patients measured using EuroQol 5D instrument, August to October 2009.

<p>TB, tuberculosis; MDR-TB, multi-drug resistant tuberculosis; TB_TX, TB patients receiving TB treatment; MDR_TX, MDR-TB patients receiving MDR-TB treatment; _anyTB_C, patients who had been successfully treated for TB or MDR-TB for ≥6 months; _anyHIV, HIV-infected patients at any stage; TB_TX/HIV, HIV-infected TB patients receiving TB treatment; _anyTB_C/HIV, HIV-infected patients who had been successfully treated for TB or MDR-TB for ≥6 months; ref, referent group.</p><p>*32 Thai Baht = 1 US$.</p

Bland-Altman plot showing the differences between health utilities measured using EuroQol 5D and EuroQol visual analogue scale instruments in relation to the mean of the two measurements in the 222 Thai patients, August to October 2009.

<p>Bland-Altman plot showing the differences between health utilities measured using EuroQol 5D and EuroQol visual analogue scale instruments in relation to the mean of the two measurements in the 222 Thai patients, August to October 2009.</p

Schematic diagram showing estimated difference in health utilities of 222 Thai patients with various medical conditions adjusting for age and monthly household income and measured using EuroQol 5D instrument, August to October 2009.

<p>Schematic diagram showing estimated difference in health utilities of 222 Thai patients with various medical conditions adjusting for age and monthly household income and measured using EuroQol 5D instrument, August to October 2009.</p

Health utilities of 222 Thai patients with various medical conditions measured using EuroQol 5D and EuroQol visual analogue score instruments, August to October 2009.

<p>TB, tuberculosis; MDR-TB, multi-drug resistant tuberculosis; EQ-5D, EuroQol 5D instrument; EQ-VAS, EuroQol visual analogue scale instrument; IQR, interquartile range; SD, standard deviation.</p

Genes that were involved in the most significantly down-regulated pathways such as Natural Killer Cell Signaling, Crosstalk between Dendritic Cells and Natural Killer Cells, CD28 Signaling in T Helper Cells, PKCθ Signaling in T Lymphocytes.

<p>The pathway names were shared between different groups but the activated genes in each pathway were different. Differentially expressed genes (FDR <0.05, fold change >2) were highlighted in grey.</p

Baseline characteristics of the patients in the study.

<p>Values are presented in median (range); WBC: white blood cell count (normal range: 4–12×10³/mm³); OFI: other febrile illness; D.O.I: day of illness; HGB: hemoglobin; HCT: hematocrit; PLT: platelet; ND: not done; Neg: negative.</p><p>Baseline characteristics of the patients in the study.</p

Difference in expression of transcripts in T cell and NK cell signaling pathways.

<p>These transcripts were only down-regulated in patients with severe symptoms but not in OFI, mild and moderate disease (*: P≤0.05).</p

Clinical manifestations of the patients in the study.

<p>Clinical manifestations of the patients in the study.</p

Interferon signaling pathways was highly up-regulated in moderate and mild influenza patients but was attenuated in patients with severe outcome.

<p>Up-regulated genes were highlighted in grey. IFNGR1 was the only gene that was up-regulated in severe patients while a large number of other genes were up-regulated in moderate and mild patients.</p