Problem spotting in human-machine interaction

In human-human communication, dialogue participants are con-tinuously sending and receiving signals on the status of the inform-ation being exchanged. We claim that if spoken dialogue systems were able to detect such cues and change their strategy accordingly, the interaction between user and systemwould improve. Therefore, the goals of the present study are as follows: (i) to find out which positive and negative cues people actually use in human-machine interaction in response to explicit and implicit verification questions and (ii) to see which (combinations of) cues have the best predictive potential for spotting the presence or absence of problems. It was found that subjects systematically use negative/marked cues (more words, marked word order, more repetitions and corrections, less new information etc.) when there are communication problems. Using precision and recall matrices it was found that various combinations of cues are accurate problem spotters. This kind of information may turn out to be highly relevant for spoken dia-logue systems, e.g., by providing quantitative criteria for changing the dialogue strategy or speech recognition engine

Performing prison:Power, agency and co-governance in Nicaraguan prisons

This thesis seeks to understand the powers and public secrecy involved in Nicaraguan prison governance. It builds on debates surrounding (hybrid) governance in Latin America and the anthropology of the state, as well as a multi-sited ethnography of the Nicaraguan carceral universe. My participation in the prison environment as the assistant facilitator of a prison theater project allowed me to conduct research with those who the state seeks to govern and control (that is, convicted prisoners and former prisoners), following them through their prison time (and into their post-release lives) over the course of 31 months between 2009 and 2016. This ethnographic engagement allowed me to observe how the (dis)ordering practices that permeate prison life implied a collusion between authorities and prisoners to manage both prison’s legal and extralegal dimensions. As these governance arrangements involved both prisoners and authorities in the ordering of prison, and a sharing of power, which moreover appeared to shape a dependence on one another for the maintenance of such arrangements, I termed them co-governance arrangements. In order to fully understand what is at stake in the emergence and maintenance of co-governance arrangements, this research tries to understand the mutuality, collusion, and embeddedness of these arrangements within the larger logics of state governance. That is, within the process of the consolidation of a “hybrid state” (in this case, a Sandinista state) in which politics, policing, and governance are entangled and arranged in what prisoners colloquially refer to as el Sistema (the System)

Transient flow-driven distortion of a nematic liquid crystal in channel flow with dissipative weak planar anchoring

Motivated by the one-drop-filling (ODF) method for the industrial manufacturing of liquid crystal displays, we analyze the pressure-driven flow of a nematic in a channel with dissipative weak planar anchoring at the boundaries of the channel. We obtain quasisteady asymptotic solutions for the director angle and the velocity in the limit of small Leslie angle, in which case the key parameters are the Ericksen number and the anchoring strength parameter. In the limit of large Ericksen number, the solution for the director angle has narrow reorientational boundary layers and a narrow reorientational internal layer separated by two outer regions in which the director is aligned at the positive Leslie angle in the lower half of the channel and the negative Leslie angle in the upper half of the channel. On the other hand, in the limit of small Ericksen number, the solution for the director angle is dominated by splay elastic effects with viscous effects appearing at first order. As the Ericksen number varies, there is a continuous transition between these asymptotic behaviors, and in fact the two asymptotic solutions capture the behavior rather well for all values of the Ericksen number. The steady-state value of the director angle at the boundaries and the timescale of the evolution toward this steady-state value in the asymptotic limits of large and small Ericksen number are determined. In particular, using estimated parameter values for the ODF method, it is found that the boundary director rotation timescale is substantially shorter than the timescale of the ODF method, suggesting that there is sufficient time for significant transient flow-driven distortion of the nematic molecules at the substrates from their required orientation to occur

Impact of food processing on the allergenic properties of amylase trypsin inhibitors from wheat

Amylase trypsin inhibitors (ATIs) play an important role in wheat allergies and potentially in non-coeliac wheat sensitivity. Food processing could be important to mitigate the pathogenic properties of ATIs, e.g., by denaturation, glycation, enzymatic hydrolysis, cross-linking, and oxidation and reduction. These modifications also impact the solubility and extractability. The complex solubility behaviour of ATI isoforms (water and salt soluble, but also chloroform–methanol soluble, solubility depending on the redox state) becomes even more complex upon processing due to denaturation and (bio)chemical modifications. This significantly hinders the feasibility of quantitative extraction. Moreover, changes in biofunctionality may occur during the process of extraction, and the changes in ATI due to food processing will be more difficult to assess. Heat treatment decreases the extractability of ATIs with water, NaCl, and other buffer extracts, and binding of IgE from wheat-allergic persons to ATIs as observed with Western blotting is decreased or absent. IgE binding is reduced with the total extract in chaotropic and reducing agents. However, it can be increased when the proteins are hydrolyzed by proteases. Fermentation involving certain species of Fructolactobacilli (FLB), followed by baking, decreases the amount of ATIs and IgE binding to ATIs. In yeast-fermented bread, the amount of ATIs decreased in a similar manner, but IgE binding was more prominent, indicating that there was a modification of ATIs that affected the epitope recognition. When isolated ATIs are ingested with high ATI degrading FLB, the immune response in mice is less elevated in vivo, when compared with ATI without high ATI degrading FLB. The pathogenic effects on the skin of dogs and one wheat-allergic child are also decreased when soluble proteins or isolated ATIs are reduced with the thioredoxin/thioredoxin reductase NADPH system. Glycation on the other hand has been shown to potentiate the allergenic properties of ATIs as evidenced by the large increase in IgE binding. The impact of food processing on the pathogenic properties of ATIs is hardly studied in vivo in humans. There seem to be opportunities to mitigate the pathogenic properties in vitro, but potentiation of pathogenic properties is also frequently observed. This requires a deeper understanding on the impact of food processing on the pathogenicity of ATIs