51 research outputs found
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114th Congress
This report focuses on several proposals for a new Authorization for Use of Military Force (AUMF) specifically targeting the Islamic State made during the 113th and 114th Congresses. It includes a brief review of existing authorities and AUMFs, as well as a discussion of issues related to various provisions included in existing and proposed AUMFs that both authorize and limit presidential use of military force. Appendices provide a comparative analysis of similar provisions in new AUMFs proposed in the 113th and 114th Congresses. This report will be updated to reflect congressional activity
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The War Powers Resolution: Concepts and Practice
This report discusses and assesses the War Powers Resolution and its application since enactment in 1973, providing detailed background on various cases in which it was used, as well as cases in which issues of its applicability were raised. It will be revised biannually
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U.S. International Broadcasting: Background and Issues for Reform
This report discusses the United States International Broadcasting Act of 1994 (USIB Act) and the U.S. international broadcasting services were consolidated under the BBG within the United States Information Agency (USIA)
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International Criminal Court and the Rome Statute: 2010 Review Conference
This report is a summary of the 2010 International Criminal Court (ICC) Review Conference in which several countries discuss political and legal ramifications of the ICC
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A New Authorization for Use of Military Force Against the Islamic State: Comparison of Current Proposals in Brief
This report discusses the President's constitutional authority to use military force against the armed offensive of the Islamic State (IS, also known as ISIL or ISIS) in northern and western Iraq and northeastern Syria. It also covers current proposals for action under congressional authorizations for use of military force (AUMFs)
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The International Criminal Court (ICC): Jurisdiction, Extradition, and U.S. Policy
This report focuses on the process by which the Office of the Prosecutor investigates allegations of war crimes and second on U.S policy towards the International Criminal Court (ICC) and how the court might assert jurisdiction over U.S. nationals
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U.S. Public Diplomacy: Background and Current Issues
This report discusses background information on U.S. public diplomacy, the current structure of public diplomacy within the Department of State as well as its budget and personnel levels, overview of some of the major related policy issues, and proposed legislation intended to reform and improve U.S. public diplomacy
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China, Internet Freedom, and U.S. Policy
This report discusses Congressional interest in how Internet use in the People's Republic of China (PRC) is tied to human rights concerns in several ways: as a U.S. policy tool for promoting rights in China; though use of the Internet political dissidents and political repression; the role of U.S. Internet companies in spreading freedom and complying with PRC censorship; and the development of U.S. Internet freedom policies globally
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International Criminal Court Cases in Africa: Status and Policy Issues
The International Criminal Court (ICC) has, to date, opened cases exclusively in Sub-Saharan Africa. The Statute of the ICC, also known as the Rome Statute, entered into force on July 1, 2002, and established a permanent, independent Court to investigate and bring to justice individuals who commit war crimes, crimes against humanity, and genocide. As of October 2010, 114 countries-including 31 African countries, the largest regional block-were parties to the Statute. The United States is not a party. This report provides background on current ICC cases and examines issues raised by the ICC's actions in Africa
Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa
Cancer patients are known to be highly susceptible to Pseudomonas aeruginosa (Pa) infection, but it remains unknown whether alterations at the tumor cell level can contribute to infection. This study explored how cellular changes associated with tumor metastasis influence Pa infection using highly metastatic MTLn3 cells and non-metastatic MTC cells as cell culture models. MTLn3 cells were found to be more sensitive to Pa infection than MTC cells based on increased translocation of the type III secretion effector, ExoS, into MTLn3 cells. Subsequent studies found that higher levels of ExoS translocation into MTLn3 cells related to Pa entry and secretion of ExoS within MTLn3 cells, rather than conventional ExoS translocation by external Pa. ExoS includes both Rho GTPase activating protein (GAP) and ADP-ribosyltransferase (ADPRT) enzyme activities, and differences in MTLn3 and MTC cell responsiveness to ExoS were found to relate to the targeting of ExoS-GAP activity to Rho GTPases. MTLn3 cell migration is mediated by RhoA activation at the leading edge, and inhibition of RhoA activity decreased ExoS translocation into MTLn3 cells to levels similar to those of MTC cells. The ability of Pa to be internalized and transfer ExoS more efficiently in association with Rho activation during tumor metastasis confirms that alterations in cell migration that occur in conjunction with tumor metastasis contribute to Pa infection in cancer patients. This study also raises the possibility that Pa might serve as a biological tool for dissecting or detecting cellular alterations associated with tumor metastasis
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