9 research outputs found

    Modeling and pricing cyber insurance - Idiosyncratic, systematic, and systemic risks

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    The paper provides a comprehensive overview of modeling and pricing cyber insurance and includes clear and easily understandable explanations of the underlying mathematical concepts. We distinguish three main types of cyber risks: idiosyncratic, systematic, and systemic cyber risks. While for idiosyncratic and systematic cyber risks, classical actuarial and financial mathematics appear to be well-suited, systemic cyber risks require more sophisticated approaches that capture both network and strategic interactions. In the context of pricing cyber insurance policies, issues of interdependence arise for both systematic and systemic cyber risks; classical actuarial valuation needs to be extended to include more complex methods, such as concepts of risk-neutral valuation and (set-valued) monetary risk measures

    Comparison of cerebral oxygen desaturation events between children under general anesthesia and chloral hydrate sedation

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    Background:\bf Background: During pediatric general anesthesia (GA) and sedation, clinicians aim to maintain physiological parameters within normal ranges. Accordingly, regional cerebral oxygen saturation (rScO2rScO_{2}) should not drop below preintervention baselines. Our study compared rScO2rScO_{2} desaturation events in children undergoing GA or chloral hydrate sedation (CHS). Methods:\bf Methods: Ninety-two children undergoing long auditory assessments were randomly assigned to two study arms: CHS (n\it n = 40) and GA (n\it n = 52). Data of 81 children (mean age 13.8 months, range 1–36 months) were analyzed. In the GA group, we followed a predefined 10 N concept (no fear, no pain, normovolemia, normotension, normocardia, normoxemia, normocapnia, normonatremia, normoglycemia, and normothermia). In this group, ENT surgeons performed minor interventions in 29 patients based on intraprocedural microscopic ear examinations. In the CHS group, recommendations for monitoring and treatment of children undergoing moderate sedation were met. Furthermore, children received a double-barreled nasal oxygen cannula to measure end-tidal carbon dioxide (etCO2etCO_{2}) and allow oxygen administration. Chloral hydrate was administered in the parent’s presence. Children had no intravenous access which is an advantage of sedation techniques. In both groups, recommendations for fasting were followed and an experienced anesthesiologist was present during the entire procedure. Adverse event (AE) was a decline in cerebral oxygenation to below 50% or below 20% from the baseline for ≄\geq1 min. The primary endpoint was the number of children with AE across the study arms. Secondary variables were: fraction of inspired oxygen (FIO2F_{I}O_{2}), oxygen saturation (SpO2S_{p}O_{2}), etCO2etCO_{2}, systolic and mean blood pressure (BP), and heart rate (HR); these variables were analyzed for their association with drop in rScO2rScO_{2} to below baseline (%drop_rScO2rScO_{2}). Results:\bf Results: The incidence of AE across groups was not different. The analysis of secondary endpoints showed evidence that %drop_rScO2rScO_{2} is more dependent on HR and FIO2F_{I}O_{2} than on BP and etCO2etCO_{2}. Conclusions:\bf Conclusions: This study highlights the strong association between HR and rScO2 in children aged < 3 years, whereas previous studies had primarily discussed the role of BP and etCO2etCO_{2}. Prompt HR correction may result in shorter periods of cerebral desaturation

    Table of contents Summary

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    i I Chapter 1: Introduction 1 1. Warm-water coral reefs 2 2. Sediment on the continental shelf 6 3. How sediment damages corals: a hypothesis 12 4. Methods and technological developments 1

    Appendix

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