8,684 research outputs found

    Basic Science and Risk Communication: A Dialogue-Based Study

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    The authors use ethnographic analysis of a focus group discussion between scientists and laypersons to study information exchange in risk communication

    Plug flow and the breakdown of Bagnold scaling in cohesive granular flows

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    Cohesive granular media flowing down an inclined plane are studied by discrete element simulations. Previous work on cohesionless granular media demonstrated that within the steady flow regime where gravitational energy is balanced by dissipation arising from intergrain forces, the velocity profile in the flow direction scales with depth in a manner consistent with the predictions of Bagnold. Here we demonstrate that this Bagnold scaling does not hold for the analogous steady-flows in cohesive granular media. We develop a generalization of the Bagnold constitutive relation to account for our observation and speculate as to the underlying physical mechanisms responsible for the different constitutive laws for cohesive and noncohesive granular media.Comment: 8 pages, 10 figure

    RANTES Secretion by Gene-Modified Tumor Cells Results in Loss of Tumorigenicity In Vivo: Role of Immune Cell Subpopulations

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    Overview summary Members of the chemokine superfamily mediate potent and selective chemoattraction of a variety of immune cell subsets, which is concentration dependent. This important and novel biologic activity raises the possibility of using chemokines as adjuvants in cancer vaccine strategies. We describe here the in vitro chemotactic capacity of RANTES for murine CD8+ tumor-infiltrating lymphocytes (TIL). Moreover, murine fibrosarcoma cells transfected with the cDNA encoding RANTES and secreting high levels of this chemokine become nontumorigenic in immunocompetent mice. The antitumor effect of RANTES is dependent on inherent tumor immunogenicity and is mediated through the participation of host-derived T cells and macrophages. Thus, the general chemoattractant properties exhibited by RANTES in vitro appear to be relevant in an in vivo model. These data warrant further investigation of other distinct members of the chemokine superfamily for their potential use, either alone or in combination, in gene therapy approaches that employ tumor cells as immunogens.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63285/1/hum.1996.7.13-1545.pd

    Universities And Business: Partnering for the Knowledge Society

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    Preface by Luc E. Weber and James J. Duderstadt Contributors and participants PART I: THE ROLE OF UNIVERSITIES, BUSINESS AND GOVERNMENT IN MEETING THE NEEDS OF SOCIETY Chapter 1, European Strategy to promote the Knowledge Society as a Source of renewed economic Dynamism and of social Cohesion Luc E. WEBER Chapter 2, University-Industry-Government Partnerships for a 21st century Global, Knowledge-Driven Economy: An American Perspective James J. DUDERSTADT Chapter 3, War and peace: how did we get here in HE-business relations? Alice FOSTER and Howard NEWBY Chapter 4, Strategic Alliances between Universities and their Communities Brenda M. GOURLEY and John L. BRENNAN Chapter 5, Higher Education Systems Dynamics and Useful Knowledge Creation Frans van VUGHT PART II: KNOWLEDGE TRANSFER Chapter 6, European Research Policy: Towards Knowledge and Innovation or Trivial Pursuit Bertil ANDERSSON Chapter 7, Knowledge Diffusion: The Prospects for More Productive University-Industry Partnerships Anita JONES Chapter 8, The Collaboration Imperative Wayne C. JOHNSON Chapter 9, Global Networks and Knowledge Diffusion: the Quantum physics model of the 21st century University William R. BRODY Chapter 10, Innovation and wealth creation Dennis TSICHRITZIS and Michael-Alexander KREYSEL PART III: THE EUROPEAN EXPERIENCE Chapter 11, The EPFL approach to Innovation Hervé LEBRET, Jan-Anders MANSON and Patrick AEBISCHER Chapter 12, Developing ongoing Research and Learning Relationships between Business Firms and Academic Institutions Sigvald HARRYSON and Peter LORANGE Chapter 13, Best Practice in Business-University Collaboration Richard LAMBERT Chapter 14, Obstacles to University–Industry Relations Horst SOBOLL Chapter 15, University-Industry Collaborations: a Source of Continuous Mutual Stimulation and Inspiration Klaus MUELLER PART IV: THE AMERICAN EXPERIENCE Chapter 16, Universities, Businesses and Public Authorities — the Inclusive Development of Society Marye Anne FOX Chapter 17, Lessons about Regional Economic Development from the Austin Story Larry FAULKNER Chapter 18, Challenges in University-Industry Collaborations Wayne C. JOHNSON Chapter 19, Effective Knowledge Transfer: from Research Universities to Industry Thomas CONNELLY PART V: HUMAN CAPITAL Chapter 20, Declining Demand among Students for Science and Engineering? Georg WINCKLER and Martin FIEDER Chapter 21, Declining Interest in Engineering Studies at a Time of Increased Business Need Wayne C. JOHNSON and Russel C. JONES Chapter 22, A Mosaic of Problems Wm. A. WULF Chapter 23, Best Practices in Knowledge Transfer Charles M. VEST PART VI: SUMMARY Chapter 24, Universities and business — a view from a food company Peter BRABECK-LETMATHE Chapter 25, University-Business Partnership for a Knowledge Society James J. DUDERSADT and Luc E. WEBERGlion Colloquiumhttp://deepblue.lib.umich.edu/bitstream/2027.42/57289/1/jjd_Universities And Business Partnering for the Knowledge Society.pd
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