Working memory, long-term memory and language processing : issues and future directions

We examined different views of the relationships between working memory, long-term memory and language processing : working memory considered as a gateway between sensory input and long-term memory or rather as a workspace; working memory considered as not strictly tied to any particular cognitive system (and consequently viewed as separated from the language system) or rather as drawing on the operation and storage capacities of a subset of components involved in language processing. It is argued that functional imagery studies (along with neuropsychological researches) could contribute to decide between these conceptions

Safety of guidewire-based measurement of fractional flow reserve and the index of microvascular resistance using intravenous adenosine in patients with acute or recent myocardial infarction

Aims: Coronary guidewire-based diagnostic assessments with hyperemia may cause iatrogenic complications. We assessed the safety of guidewire-based measurement of coronary physiology, using intravenous adenosine, in patients with an acute coronary syndrome. Methods: We prospectively enrolled invasively managed STEMI and NSTEMI patients in two simultaneously conducted studies in 6 centers (NCT01764334; NCT02072850). All of the participants underwent a diagnostic coronary guidewire study using intravenous adenosine (140 μg/kg/min) infusion for 1–2 min. The patients were prospectively assessed for the occurrence of serious adverse events (SAEs) and symptoms and invasively measured hemodynamics were also recorded. Results: 648 patients (n = 298 STEMI patients in 1 hospital; mean time to reperfusion 253 min; n = 350 NSTEMI in 6 hospitals; median time to angiography from index chest pain episode 3 (2, 5) days) were included between March 2011 and May 2013. Two NSTEMI patients (0.03% overall) experienced a coronary dissection related to the guidewire. No guidewire dissections occurred in the STEMI patients. Chest symptoms were reported in the majority (86%) of patient's symptoms during the adenosine infusion. No serious adverse events occurred during infusion of adenosine and all of the symptoms resolved after the infusion ceased. Conclusions: In this multicenter analysis, guidewire-based measurement of FFR and IMR using intravenous adenosine was safe in patients following STEMI or NSTEMI. Self-limiting symptoms were common but not associated with serious adverse events. Finally, coronary dissection in STEMI and NSTEMI patients was noted to be a rare phenomenon

Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten

Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disorder of the heart, but effective treatment options remain limited. Mavacamten, a direct myosin modulator, has been presented as novel pharmacological therapy for HCM. The aim of this study was to analyze the biomechanical response of HCM tissue to Mavacamten using living myocardial slices (LMS). LMS (n = 58) from patients with HCM (n = 10) were cultured under electromechanical stimulation, and Verapamil and Mavacamten were administered on consecutive days to evaluate their effects on cardiac biomechanics. Mavacamten and Verapamil reduced contractile force and dF/dt and increased time-to-relaxation in a similar manner. Yet, the time-to-peak of the cardiac contraction was prolonged after administration of Mavacamten (221.0 ms (208.8 – 236.3) vs. 237.7 (221.0 – 254.7), p = 0.004). In addition, Mavacamten prolonged the functional refractory period (FRP) (330 ms (304 − 351) vs. 355 ms (313 − 370), p = 0.023) and better preserved twitch force with increasing stimulation frequencies, compared to Verapamil. As such, Mavacamten reduced (hyper-)contractility and prolonged contraction duration of HCM LMS, suggesting a reduction in cardiac wall stress. Also, Mavacamten might protect against the development of ventricular tachyarrhythmias due to prolongation of the FRP, and improve toleration of tachycardia due to better preservation of twitch force at tachycardiac stimulation frequencies.</p

Evaluation of winter range habitat treatments on overwinter survival, density, and body condition of mule deer

2013 Summer.Includes bibliographical references.To view the abstract, please see the full text of the document

X-linked adrenoleukodystrophy: Clinical, biochemical and pathogenetic aspects

AbstractX-linked adrenoleukodystrophy (X-ALD) is a clinically heterogeneous disorder ranging from the severe childhood cerebral form to asymptomatic persons. The overall incidence is 1:16,800 including hemizygotes as well as heterozygotes. The principal molecular defect is due to inborn mutations in the ABCD1 gene encoding the adrenoleukodystrophy protein (ALDP), a transporter in the peroxisome membrane. ALDP is involved in the transport of substrates from the cytoplasm into the peroxisomal lumen. ALDP defects lead to characteristic accumulation of saturated very long-chain fatty acids, the diagnostic disease marker. The pathogenesis is unclear. Different molecular mechanisms seem to induce inflammatory demyelination, neurodegeneration and adrenocortical insufficiency involving the primary ABCD1 defect, environmental factors and modifier genes. Important information has been derived from the X-ALD mouse models; species differences however complicate the interpretation of results. So far, bone marrow transplantation is the only effective long-term treatment for childhood cerebral X-ALD, however, only when performed at an early-stage of disease. Urgently needed novel therapeutic strategies are under consideration ranging from dietary approaches to gene therapy

A type catalog of fossil invertebrates (Echinodermata) in the Yale Peabody Museum

Type material for 126 nominal species of fossil echinoderms are in the Invertebrate Paleontology Collections of Yale University\u27s Peabody Museum of Natural History. Primary types for 38 nominal species include 25 holotypes, 31 syntypes (representing 12 nominal species) and 1 neotype. Secondary types for 3 nominal species include 5 paratypes. Tertiary types of 76 nominal species include 403 hypotypes. Most types are from Crawfordsville (Indiana), New York State and Tennessee and have been described by W.B. Clark, R.T. Jackson, N.G. Lane, R.C. Moore, C. Schuchert, F.Springer and J.F. Van Sant

The effect of hypnotherapy on the quality of life in women with breast cancer

Background. Cancer is a chronic disease that significantly affects the quality of life of patients who suffer from it, because they must face stressful situations, including their diagnosis, surgical procedures, and the adverse effects of chemotherapy and radiotherapy. Objective. To evaluate the effects of hypnotherapy on breast cancer patients’ quality of life during chemotherapy. Design. A quasi-experimental design was used with a convenience sample. Method. Two groups of patients with early breast cancer diagnoses were assigned to either a control group that received standard medical care (n = 20), or a hypnotherapy group (n = 20) that received 12 intensive sessions over the course of 1 month, and 12 additional sessions over the course of 6 months. The patients’ quality of life was evaluated using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Results. The hypnotherapy group showed a statistically significant improvement and a large effect size on the cognitive functioning and social functioning scales compared to the control group. The physical functioning, role functioning, and quality of life scales showed improvement with a medium effect size, but the changes were not statistically significant. Conclusion. The improvement observed in the cognitive functioning and social functioning scales allows us to suggest that hypnotherapy improves the quality of life of breast cancer patients during chemotherapy. Keywords: hypnotherapy, quality of life, breast cancer, cognitive functioning and social functionin