Impaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the Hong Kong Chinese population: a 5-year prospective study

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The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas

Aims - Phaeochromocytomas and paragangliomas are uncommon. The aims of this study were to analyse the characteristics and the possible roles of p53, Rb, and mdm2 alterations in these tumours. Methods - The clinicopathological features of 65 patients (31 men, 34 women) with phaeochromocytomas or paragangliomas were analysed. The tumours were studied for the expression of p53, Rb, and mdm2 by immunohistochemical methods. Results - Thirty nine of the patients had phaeochromocytomas and 26 had paragangliomas. Bilateral tumours were noted in eight of the patients and malignant tumours were seen in 13. Paragangliomas were often small, non-functional, and presented incidentally, whereas phaeochromocytomas were usually large, functional, and symptomatic, p53 overexpression, loss of Rb expression, and mdm2 overexpression were seen in four, 43, and 37 of the patients, respectively. Three of the four patients with p53 overexpression had bilateral tumours. Loss of Rb expression was often found in phaeochromocytomas, whereas mdm2 overexpression was more frequently seen in paragangliomas. The 10 year survival rate of patients with malignant tumours was 45%. Two patients died of tumour metastases more than 10 years after resection of the primary tumours. Conclusions - Phaeochromocytomas and paragangliomas had distinctive clinical features and genetic alterations. The prognosis of patients with these tumours was related to the malignant potential, p53 overexpression, more common in bilateral phaeochromocytomas and paragangliomas, could be a marker for this tumour subgroup.published_or_final_versio

Changes in blood pressure after 6 years in the Hong Kong cardiovascular risk factor prevalence survey cohort

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Circulating pigment epithelium-derived factor levels and the risk of hypertension in a community-based study

Oral Session 2 – Translational & Clinical Research (I)published_or_final_versionThe 16th Medical Resarch Conference (MRC), The University of Hong Kong, Hong Kong, China, 22 January 2011. In Hong Kong Medical Journal, 2011, v. 17, suppl. 1, p. 15, abstract no. 1

Serum adiponectin in relation to other obesity-related biomarkers in predicting type 2 diabetes: a 5-year prospective study

Oral PresentationAIMS: To identify obesity-related serum biomarkers associated with the development of type 2 diabetes in a Chinese population and to examine if these biomarkers added values to conventional risk factors in diabetes prediction. METHODS: We studied 1315 non-diabetic subjects from the prospective Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). Serum biomarkers including adiponectin, tumour necrosis …published_or_final_versionThe 17th Medical Research Conference, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 57, abstract no. 8

The clinical genetics of multiple endocrine neoplasia type 1 in Chinese

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Sino-U.S. economic relations: problems and perspectives

U.S.-China economic relations are currently strained as a direct result of the Chinese crackdown of demonstrators in Tiananmen square on June 4, 1989. However, the brutal suppression of the demonstrators is only one aspect of the overall Sino-U.S. economic relationship. This thesis examines the economic relationship beginning in 1978, when China embarked on its modernization effort. Though China has made many improvements in these efforts their modernization effort does not necessarily coincide with United States' desires. Instead, China is concerned with maintaining its socialist character for the foreseeable future. This thesis examines divergent Sino-U.S. economic relations, and offers some various recommendations for American policy-makers depending on the course that China's leadership decides to take. Financial aid, Four modernizations, Most favored nation, New reforms, Reform, Socialism, Technology transfers, Trade relations, U.S. Policyhttp://archive.org/details/sinouseconomicre00kingLieutenant, United States NavyApproved for public release; distribution is unlimited

Implication of the type 2 diabetes susceptibility loci identified in genome-wide association studies: long-term follow-up studies in Southern Chinese

Poster PresentationOBJECTIVE: Genome-wide association (GWA) studies have led to the identification of novel susceptibility loci which showed promising associations with type 2 diabetes (T2DM). This project aimed to establish the role of these novel T2DM-susceptibility loci in Southern Chinese. METHODS: Seventeen T2DM-associated single nucleotide polymorphisms (SNPs) were examined …published_or_final_versionThe 17th Medical Research Conference, The University of Hong Kong, Hong Kong, 14 January 2012. In Hong Kong Medical Journal, 2012, v. 18 suppl. 1, p. 19, abstract no. 1

Association of the KCNJ11 genetic variant (rs5219) with progression of glycaemia in a 12-year prospective study

Poster PresentationOBJECTIVE: The potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) genetic variant, rs5219, has been found to be associated with type 2 diabetes mellitus (T2DM) in various populations. This project aimed to examine whether this genetic variant could predict the progression of glycaemia in a 12-year prospective study in Southern Chinese. METHODS: We conducted a 12-year prospective study in the population-based …published_or_final_versionThe 16th Medical Research Conference, The University of Hong Kong, Hong Kong, 22 January 2011. In Hong Kong Medical Journal, 2011, v. 17 suppl. 1, p. 20, abstract no. 2

Textile Waste Fiber-Reinforced Mortar: performance evaluation

Trabalho apresentado em 1st International AFRICA Sustainable Waste Management Conference, 23-25 July 2012, Lobito, AngolaN/