Utvrđivanje uloge logistike u administraciji rezervnih dijelova na primjeru jedne čeličane

Material supply in metallurgy concerns to very wide range of assortment. The different cost of receiving and different meaning to the production and quality of finished product are connected with them. The considerable share of material cost and maintenance costs of reserves are only some problems which decide about essential role of supply. The application of logistic elements in strategy of supply can be the essential instrument of rationalization in the processes of material flow and administration of supply. In the work the areas of application of logistic in the range of supply on the example of steel work have been defined. The base to determine the purchases policy was detailed analysis of supply situation and estimation of the position of enterprise in the market and the choice of strategy of storage of supply.Nabava materijala u metalurgiji odnosi se na vrlo široki asortiman. S time su povezane različite cijene nabave i različiti značaj materijala za proizvodnju kvalitetnih gotovih proizvoda. Značajan dio materijalnih troškova i troškova održavanja rezervnih dijelova samo su neki od problema koji odlučuju o bitnoj ulozi nabave. Primjena logističkih elemenata u strategiji nabave može biti odlučujući instrument za racionalizaciju procesa protoka materijala i upravljanje nabavom. U radu su definirana područja primjene za djelokrug nabave na primjeru čeličane. Osnova za utvrđivanje politike nabave je bila detaljna analiza tržišta nabave i utvrđivanja položaja poduzeća na tržištu, i izbor strategije skladištenja nabavljene robe

Modifcation and Improvement of Human Resource Management System in Metallurgical Enterprise

In this paper the example of methodic of proceeding in analysis and modification of human resource management system are presented. Besides results of research carried on analyzed question on the example of chosen unit of metallurgical enterprise are discussed

Evaluation of anticonvulsants for possible use in neuropathic pain

Neuropathic pain is a kind of pain related with functional abnormality of neurons. Despite large progress in pharmacotherapy, neuropathic pain is still considered an unmet need. Nowadays, there are few drugs registered for this condition, such as pregabalin, gabapentin, duloxetine, carbamazepine, and lidocaine. Among them, pregabalin, gabapentin and carbamazepine are well known antiepileptic drugs. Among the group of new antiepileptic drugs, which are addressed to 1% of human world population suffering from seizures, it turned out that 30% of the seizures resistant to pharmacotherapy has not enough market to justify the costs of drug development. Therefore, it is already a phenomenon that researchers turn their projects toward a larger market, related with possible similar mechanism. Anticonvulsant mechanism of action is in the first place among primary indications for drugs revealing potential analgesic activity. Therefore, many drug candidates for epilepsy, still in preclinical stage, are being evaluated for activity in neuropathic pain. This review is focusing on antiepileptic drugs, which are evaluated for their analgesic activity in major tests related with neuropathic pain. Relation between structure, mechanism of action and result in tests such as the Chung model (spinal nerve ligation SNL), the Bennett model (chronic constriction injury of sciatic nerve CCI) and other tests are considered. The first examples are carbamazepine, gabapentin, and lacosamide as drugs well established in epilepsy market as well as drug candidates such as valnoctamide, and other valproic acid derivatives, novel biphenyl pyrazole derivatives, etc. Moreover, clinical efficacy related with listed animal models has been discussed

Mogućnosti kvalitativne i kvantitativne prilagodbe ljudskih resursa na primjeru odabranog pogona metalurškog poduzeća

One of basic tasks of human resource management in a metallurgical enterprise is assurance of workers with correct - from organization point of view - competences. These activities are possible only when competences needed in the enterprise are recognized and the influence of particular competences on correct course of manufacturing process is described. This enables the enterprise to have an access to exact qualification of workers’ profiles which should be applied on stage of selection. In this paper, on the example of chosen unit of metallurgical enterprise, methods possible to use in human resource management are presented.Jedan od osnovnih zadataka upravljanja ljudskim resursima u nekom metalurškom poduzeću je osiguravanje dovoljnog broja radnika s odgovarajućim odgovornostima - gledajući s točke gledišta organizacije. Takve aktivnosti su moguće samo onda ako organizacija zna prepoznati koje odgovornosti su joj potrebne i ako je (unaprijed) opisan njihov utjecaj na ispravan tijek proizvodnog procesa. To omogućuje poduzeću da ima pristup točnim kvalifikacijama profila radnika koje će se primijeniti u fazi odabira. U ovom radu su prikazane na primjeru jednog pogona nekog metalurškog poduzeća metode koje se mogu primijeniti u upravljanju ljudskim resursima

Analiza materijala i protoka informacija u logističkom sustavu neke odabrane čeličane

Tough competition on the steel product market causes the functioning of steelworks largely to depend on their abilities to respond flexibly to the market needs and offer the right product, at the right price and in the right time. A tool which is more and more commonly used for achieving this goal is logistics. The function of logistics in a production company is the optimal shaping of the stream of materials and information flowing through the company. The article reports the result of an analysis of material and information flows on the example of a selected metallurgical enterprise.Jaka konkurencija na tržištu čeličnih proizvoda dovodi do toga da funkcioniranje čeličana uvelike ovisi o njihovoj sposobnosti da fleksibilno odgovore potrebama tržišta i ponude pravi proizvod po pravoj cijeni u pravo vrijeme. Sve se više koristi za postizanje tog cilja logistika. Funkcija logistike u nekom proizvodnom poduzeću je u tome da osigura optimalan protok materijala i informacija kroz poduzeće. Članak predstavlja rezultat analize protoka materijala i informacija na primjeru jednog metalurškog poduzeća

Synthesis and evaluation of anticonvulsant activity of N-(2,5-dimethylphenoxy)- and N-[(2,3,5-trimethylphenoxy)alkyl]aminoalkanols

A series of new N-(2,5-dimethylphenoxy)- and N-(2,3,5-trimethylphenoxy)alkylaminoalkanols [I-XVII] was synthesized and evaluated for anticonvulsant activity. Pharmacological tests included maximal electroshock (MES) and subcutaneous pentetrazole seizure threshold (scMet) assays as well as neurotoxicity (TOX) evaluation in mice after intraperitoneal (i.p.) administration and/or in rats after oral (p.o.) administration. The most active compound was R-2N-[(2,3,5-trimethylphenoxy)ethyl]aminobutan-1-ol, which exhibited 100% activity in MES at the dose of 30 mg/kg body weight (mice, i.p.) and 75% activity in MES at 30 mg/kg b.w. (rats, p.o.) without neurotoxicity at the active doses

Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals

Purpose. Besides being widely used in cosmetics, retinoids are potent therapeutic agents used topically and systemically as anti-acne agents. The aim of this study was to predict with the use of MetaSite the skin metabolism of selected retinoids employed in treatment of skin disorders and found in cosmeceuticals. The following compounds were studied: retinol, retinaldehyde, retinoic acid, retinyl acetate, retinyl palmitate, acitretin, etretinate, adapalene and bexarotene. Methods. MetaSite, Molecular Discovery Ltd. is a computational model that enables prediction of cytochrome P450-dependant metabolism. This software indicates atoms in the molecule structure that are mostly vulnerable to metabolic changes and predicts the metabolite structures. Results. MetaSite indicated that retinol and retinal metabolites were obtained through hydroxylation of the methyl group located in the position 3 of the aliphatic chain, whereas retinoic acid biotransformation would occur principally in the carbon atom situated in the position 4 in the cyclohexene ring. In acitretin molecule, carbon atom of the methoxy group attached to the benzene ring displayed the highest probability of biotransformation. In etretinate, metabolic reactions would occur principally on the carbon atom of the final ethyl group of the molecule. Conclusions. MetaSite metabolism predictions for retinoic acid, acitretin, etretinate, adapalene and bexarotene were in agreement with experimental findings. In case of compounds being converted by catalysts other than cytochrome P450 enzymes, the primary metabolites predicted by MetaSite differ from those reported previously. In conclusion, MetaSite is a useful tool that can aid identification of the major metabolites of compounds being administered topically