Sirolimus plus sorafenib in treating HCC recurrence after liver transplantation: A case report

A case of hepatocellular carcinoma (HCC) with pulmonary recurrence after liver transplantation for HCC is presented in this report. The patient showed disease progression on sorafenib therapy demonstrated by computed tomography scans as well as serial serum α-fetoprotein (AFP) elevation. After his immunosuppression therapy was successfully transitioned to sirolimus and a continuation of sorafenib, he achieved partial remission based on RECIST criteria and normalization of AFP. Mammalian target of rapamycin inhibitors including sirolimus alone or in conjunction with sorafenib may be useful in the treatment of post transplant HCC

Epidemiologic factors and urogenital infections associated with preterm birth in a midwestern U.S. population

OBJECTIVE: To correlate epidemiologic factors with urogenital infections associated with preterm birth. METHODS: Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for potential pathogens. RESULTS: Six hundred seventy-six women were evaluated. Fifty-four (8.0%) had preterm birth: 12.1% (19/157) large urban, 8.8% (15/170) midsize urban, 9.4% (16/171) small city, and 2.3% (4/178) rural city. Associated host factors and infections varied significantly among sites. Urogenital infection rates, especially Mycoplasma hominis and Ureaplasma parvum, were highest at the large urban site. Large urban site, minority ethnicity, multiple infections, and certain historical factors were associated with preterm birth by univariable analysis. By multivariable analysis, preterm birth was associated with prior preterm birth (adjusted odds ratio [aOR] 2.76, 95% confidence interval [CI] 1.27-6.02) and urinary tract infection (aOR 2.62, 95% CI 1.32-519), and negatively associated with provider-assessed good health (aOR 0.42, 95% CI 0.23-0.76) and group B streptococcal infection treatment (surrogate for health care use) (aOR 0.38, 95% CI 0.15-.99). Risk and protective factors were similar for women with birth at less than 35 weeks, and additionally associated with M hominis (aOR 3.6, 95% CI 1.4-9.7). CONCLUSION: These measured differences among sites are consistent with observations that link epidemiologic factors, both environmental and genetic, with minimally pathogenic vaginal bacteria, inducing preterm birth, especially at less than 35 weeks of gestation. LEVEL OF EVIDENCE: II

Animal Production Systems for Pasture-Based Livestock Production (NRAES 171)

This 246 page publication (NRAES-171) was originally published by the Natural Resource, Agriculture, and Engineering Service (NRAES, previously known as the Northeast Regional Agricultural Engineering Service), a multi-university program in the Northeast US disbanded in 2011. Plant and Life Sciences Publishing (PALS) was subsequently formed to manage the NRAES catalog. Ceasing operations in 2018, PALS was a program of the Department of Horticulture in the College of Agriculture and Life Sciences (CALS) at Cornell University. PALS assisted university faculty in publishing, marketing and distributing books for small farmers, gardeners, land owners, workshops, college courses, and consumers.The book explores foraging behavior, basic animal nutrition, and parasite control for pasture-based animals with chapters devoted to beef, dairy, sheep, goat, and horse nutrition and management

Reduced <i>Ppd</i> chromosomes at birth – CZECHII/EiJ cross.

<p>Reduced <i>Ppd</i> chromosomes at birth – CZECHII/EiJ cross.</p

Typical <i>Ppd</i> caudal duplications, among numerous anomalies observed in mutants.

<p>Please see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003967#pgen.1003967-Lehoczky1" target="_blank">[15]</a> for a complete description of other anomalies, listed in the Introduction. Variation in presentation of ectopic legs with or without caudal masses has been observed.</p

<i>Ppd</i> characteristic caudal mass/ectopic limb phenotypes in engineered offspring.

<p>A. (one panel) Bruce4.G9 targeted ES cell clone (9281)-derived chimeric male produced a female heterozygous carrier (Neo⁺/eETn⁺) that was mated to a β-actin FLPe male to produce the newborn (Neo⁻/eETn⁺) shown in the panel here. Genotyping confirmed the proper FLPe recombination fragment demonstrating Neo cassette removal in this mouse. B., C. Typical caudal masses with ectopic limbs in offspring of Neo⁻/eETn⁺ mice. 9 out of 69 offspring from mating between Neo⁻/eETn⁺ males X B6/D2 F₁ females demonstrated typical caudal masses/ectopic limbs (3 panels in B), whereas 8 out of 31 offspring from mating between Neo⁻/eETn⁺ males X FVB females demonstrated typical caudal masses and in one mouse a bifurcated tail seen at birth and later at 3 weeks (5 panels in C).</p

Expected Mendelian numbers of <i>Ppd</i> X-chromosomes at E9.5.

<p>Expected Mendelian numbers of <i>Ppd</i> X-chromosomes at E9.5.</p

Reduced <i>Ppd</i> chromosomes at birth – C3H cross.

<p>Reduced <i>Ppd</i> chromosomes at birth – C3H cross.</p