Quantum metrology and its application in biology

Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artifacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient detail to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science.Comment: Submitted review article, comments and suggestions welcom

Injection locking of an electro-optomechanical device

The techniques of cavity optomechanics have enabled significant achievements in precision sensing, including the detection of gravitational waves and the cooling of mechanical systems to their quantum ground state. Recently, the inherent non-linearity in the optomechanical interaction has been harnessed to explore synchronization effects, including the spontaneous locking of an oscillator to a reference injection signal delivered via the optical field. Here, we present the first demonstration of a radiation-pressure driven optomechanical system locking to an inertial drive, with actuation provided by an integrated electrical interface. We use the injection signal to suppress drift in the optomechanical oscillation frequency, strongly reducing phase noise by over 55 dBc/Hz at 2 Hz offset. We further employ the injection tone to tune the oscillation frequency by more than 2 million times its narrowed linewidth. In addition, we uncover previously unreported synchronization dynamics, enabled by the independence of the inertial drive from the optical drive field. Finally, we show that our approach may enable control of the optomechanical gain competition between different mechanical modes of a single resonator. The electrical interface allows enhanced scalability for future applications involving arrays of injection-locked precision sensors.Comment: Main text: 10 pages, 7 figures. Supplementary Information: 5 pages, 4 figure

Experimental demonstration of continuous variable polarization entanglement

We report the experimental transformation of quadrature entanglement between two optical beams into continuous variable polarization entanglement. We extend the inseparability criterion proposed by Duan, et al. [Duan00] to polarization states and use it to quantify the entanglement between the three Stokes operators of the beams. We propose an extension to this scheme utilizing two quadrature entangled pairs for which all three Stokes operators between a pair of beams are entangled.Comment: 4 pages, 4 figure

Feedback Enhanced Sensitivity in Optomechanics: Surpassing the Parametric Instability Barrier

The intracavity power, and hence sensitivity, of optomechanical sensors is commonly limited by parametric instability. Here we characterize the parametric instability induced sensitivity degradation in a micron scale cavity optomechanical system. Feedback via optomechanical transduction and electrical gradient force actuation is applied to suppress the parametric instability. As a result a 5.4 fold increase in mechanical motion transduction sensitivity is achieved to a final value of $1.9\times 10^{-18}\rm m Hz^{-1/2}$.Comment: 4 pages, 4 figure

Detuned Mechanical Parametric Amplification as a Quantum Non-Demolition Measurement

Recently it has been demonstrated that the combination of weak-continuous position detection with detuned parametric driving can lead to significant steady-state mechanical squeezing, far beyond the 3 dB limit normally associated with parametric driving. In this work, we show the close connection between this detuned scheme and quantum non-demolition (QND) measurement of a single mechanical quadrature. In particular, we show that applying an experimentally realistic detuned parametric drive to a cavity optomechanical system allows one to effectively realize a QND measurement despite being in the bad-cavity limit. In the limit of strong squeezing, we show that this scheme offers significant advantages over standard backaction evasion, not only by allowing operation in the weak measurement and low efficiency regimes, but also in terms of the purity of the mechanical state.Comment: 17 pages, 2 figure

Harmonic entanglement with second-order non-linearity

We investigate the second-order non-linear interaction as a means to generate entanglement between fields of differing wavelengths. And show that perfect entanglement can, in principle, be produced between the fundamental and second harmonic fields in these processes. Neither pure second harmonic generation, nor parametric oscillation optimally produce entanglement, such optimal entanglement is rather produced by an intermediate process. An experimental demonstration of these predictions should be imminently feasible.Comment: 4 pages, 4 figure

Mechanical Entanglement via Detuned Parametric Amplification

We propose two schemes to generate entanglement between a pair of mechanical oscillators using parametric amplification. In contrast to existing parametric drive-based protocols, both schemes operate in the steady-state. Using a detuned parametric drive to maintain equilibrium and to couple orthogonal quadratures, our approach can be viewed as a two-mode extension of previous proposals for parametric squeezing. We find that robust steady-state entanglement is possible for matched oscillators with well-controlled coupling. In addition, one of the proposed schemes is robust to differences in the damping rates of the two oscillators.Comment: 13 pages, 2 figure

Quantum optomechanics beyond the quantum coherent oscillation regime

Interaction with a thermal environment decoheres the quantum state of a mechanical oscillator. When the interaction is sufficiently strong, such that more than one thermal phonon is introduced within a period of oscillation, quantum coherent oscillations are prevented. This is generally thought to preclude a wide range of quantum protocols. Here, we introduce a pulsed optomechanical protocol that allows ground state cooling, general linear quantum non-demolition measurements, optomechanical state swaps, and quantum state preparation and tomography without requiring quantum coherent oscillations. Finally we show how the protocol can break the usual thermal limit for sensing of impulse forces.Comment: 6 pages, 3 figure

Minimum requirements for feedback enhanced force sensing

The problem of estimating an unknown force driving a linear oscillator is revisited. When using linear measurement, feedback is often cited as a mechanism to enhance bandwidth or sensitivity. We show that as long as the oscillator dynamics are known, there exists a real-time estimation strategy that reproduces the same measurement record as any arbitrary feedback protocol. Consequently some form of nonlinearity is required to gain any advantage beyond estimation alone. This result holds true in both quantum and classical systems, with non-stationary forces and feedback, and in the general case of non-Gaussian and correlated noise. Recently, feedback enhanced incoherent force sensing has been demonstrated [Nat. Nano. \textbf{7}, 509 (2012)], with the enhancement attributed to a feedback induced modification of the mechanical susceptibility. As a proof-of-principle we experimentally reproduce this result through straightforward filtering.Comment: 5 pages + 2 pages of Supplementary Informatio

On the transduction of various noise sources in optical microtoroids

Optical microresonators constitute the basic building block for numerous precision measurements including single-particle detection, magnetometry, force and position sensing. The ability to resolve a signal of interest is limited however by various noise sources. In this tutorial style paper we provide a matrix formalism to analyze the effect of various modulations upon the optical cavity. The technique can in principle be used to estimate the sensitivity of microresonator based sensors and potentially to identify the optimal detection basis and cavity parameters to optimise the signal to noise ratio