Quantum metrology and its application in biology

Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artifacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient detail to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science.Comment: Submitted review article, comments and suggestions welcom

Monitoring RXTE Observations of Markarian 348: the origin of the column density variations

We analyze 37 RXTE observations of the type 2 Seyfert galaxy Mrk348 obtained during a period of 14 months. We confirm the spectral variability previous reported by Smith et al., in the sense that thecolumn density decreases by a factor of ~3 as the count rate increases. Column density variations could possibly originate either due to the random drift of clouds within the absorption screen, or due to photoionization processes. Our modeling of the observed variations implies that the first scenario is more likely. These clouds should lie in a distance of >2 light years from the source, having a diameter of a few light days and a density of >10^7 cm^(-3), hence probably residing outside the Broad Line Region.Comment: 6 pages, 3 figures, to appear in MNRA

The XMM-Newton slew survey in the 2-10 keV band

The XMM-Newton Slew Survey (XSS) covers a significant fraction of the sky in a broad X-ray bandpass. Although shallow by contemporary standards, in the `classical' 2-10 keV band of X-ray astronomy, the XSS provides significantly better sensitivity than any currently available all-sky survey. We investigate the source content of the XSS, focussing on detections in the 2-10 keV band down to a very low threshold (> 4 counts net of background). At the faint end, the survey reaches a flux sensitivity of roughly 3e-12 erg/cm2/s (2-10 keV). Our starting point was a sample of 487 sources detected in the XMMSL1d2 XSS at high galactic latitude in the hard band. Through cross-correlation with published source catalogues from surveys spanning the electromagnetic spectrum from radio to gamma-rays, we find that 45% of the sources have likely identifications with normal/active galaxies, 18% are associated with other classes of X-ray object (nearby coronally active stars, accreting binaries, clusters of galaxies), leaving 37% of the XSS sources with no current identification. We go on to define an XSS extragalactic hard band sample comprised of 219 galaxies and active galaxies. We investigate the properties of this extragalactic sample including its X-ray logN-logS distribution. We find that in the low-count limit, the XSS is strongly affected by Eddington bias. There is also a very strong bias in the XSS against the detection of extended sources, most notably clusters of galaxies. A significant fraction of the detections at and around the low-count limit may be spurious. Nevertheless, it is possible to use the XSS to extract a reasonably robust sample of extragalactic sources, excluding galaxy clusters. The differential logN-logS relation of these extragalactic sources matches very well to the HEAO-1 A2 all-sky survey measurements at bright fluxes and to the 2XMM source counts at the faint end.Comment: 16 pages, 13 figures, FITS table of XSS extragalactic sample available from http://www.star.le.ac.uk/~amr30/Slew

Mental health and emotional well-being of students in further education - a scoping study

This study aimed to explore how FE colleges in England are engaging with and addressing the mental health needs of their young students (aged 16-19), both in terms of promoting positive mental health and emotional well-being and in responding to identified mental health problems

Information seeking in the Humanities: physicality and digitality

This paper presents a brief overview of a research project that is examining the information seeking practices of humanities scholars. The results of this project are being used to develop digital resources to better support these work activities. Initial findings from a recent set of interviews is offered, revealing the importance of physical artefacts in the humanities scholars’ research processes and the limitations of digital resources. Finally, further work that is soon to be undertaken is summarised, and it is hoped that after participation in this workshop these ideas will be refined

Detuned Mechanical Parametric Amplification as a Quantum Non-Demolition Measurement

Recently it has been demonstrated that the combination of weak-continuous position detection with detuned parametric driving can lead to significant steady-state mechanical squeezing, far beyond the 3 dB limit normally associated with parametric driving. In this work, we show the close connection between this detuned scheme and quantum non-demolition (QND) measurement of a single mechanical quadrature. In particular, we show that applying an experimentally realistic detuned parametric drive to a cavity optomechanical system allows one to effectively realize a QND measurement despite being in the bad-cavity limit. In the limit of strong squeezing, we show that this scheme offers significant advantages over standard backaction evasion, not only by allowing operation in the weak measurement and low efficiency regimes, but also in terms of the purity of the mechanical state.Comment: 17 pages, 2 figure