Urban forest usage and perception of ecosystem services – A comparison between teenagers and adults

We thank Christoph Düggelin and Marc Baume for the interpretation of the photographs and two anonymous reviewers for comments on the manuscript. The project was funded by the Swiss State Secretariat for Education, Research and Innovation SERI, Switzerland (Grant No. C13.0135) as a contribution to the COST Action PF1204 and by the Swiss Federal Office for the Environment, Switzerland (Grant No. 16.0074.PJ / S062-1129).Peer reviewedPublisher PD

Retrospective and Recent Examples of Aircraft and Rotorcraft System Identification at DLR

Aircraft system identification has a five-decades-long tradition at German Aerospace Center (DLR). Over the last two decades, the research covered various topics related to system identification of fixed- and rotary-wing aircraft, nonconventional applications and atmospheric effects, the development of new flight-test procedures for system identification purposes, and specific aircraft model enhancements and corresponding parameter estimation. Comprehensive tools were developed that support this research and can be applied to a variety of different problems and types of vehicles. The paper starts with a short description of the different system identification methods used at DLR and the corresponding tools. The discussion of flight-test procedures and maneuver design as well as sensor fusion and flight-path reconstruction provides information on how to optimize the flight tests for system identification and to arrive at a consistent flight-test database. The examples for fixed-wing aircraft provide information on identification including abnormal conditions such as icing and interaction with atmospheric disturbances as well as modeling of structural mechanics and loads. The identification of high-order rotorcraft models that account for rotor and engine dynamics and even structural modes is discussed, and the identification of rotor mast moments as well as the identification of non-physics-based models and their integration into physics-based models are also covered. A final section shows that system identification can also be used to derive models for gyroplanes and parachutes as well as to derive control equivalent turbulence input models and to estimate complex wind field geometries. Thus, a broad overview of possible applications of system identification is given

Sensory Ion Channel Candidates Inform on the Clinical Course of Pancreatic Cancer and Present Potential Targets for Repurposing of FDA-Approved Agents

Background: Transient receptor potential channels (TRPs) have been demonstrated to take on functions in pancreatic adenocarcinoma (PAAD) biology. However, little data are available that validate the potential of TRP in a clinical translational setting. Methods: A TRPs-related gene signature was constructed based on the Cox regression using a TCGA-PAAD cohort and receiver operating characteristic (ROC) was used to evaluate the predictive ability of this model. Core genes of the signature were screened by a protein-to-protein interaction (PPI) network, and expression validated by two independent datasets. The mutation analysis and gene set enrichment analysis (GSEA) were conducted. Virtual interventions screening was performed to discover substance candidates for the identified target genes. Results: A four TRPs-related gene signature, which contained MCOLN1, PKD1, TRPC3, and TRPC7, was developed and the area under the curve (AUC) was 0.758. Kaplan–Meier analysis revealed that patients with elevated signature score classify as a high-risk group featuring significantly shorter recurrence free survival (RFS) time, compared to the low-risk patients (p < 0.001). The gene prediction model also had a good predictive capability for predicting shortened overall survival (OS) and disease-specific survival (DSS) (AUC = 0.680 and AUC = 0.739, respectively). GSEA enrichment revealed the core genes of the signature, TRPC3 and TRPC7, were involved in several cancer-related pathways. TRPC3 mRNA is elevated in cancer tissue compared to control tissue and augmented in tumors with lymph node invasion compared to tumors without signs of lymph node invasion. Virtual substance screening of FDA approved compounds indicates that four small molecular compounds might be potentially selective not only for TRPC3 protein but also as a potential binding partner to TRPC7 protein. Conclusions: Our computational pipeline constructed a four TRP-related gene signature that enables us to predict clinical prognostic value of hitherto unrecognized biomarkers for PAAD. Sensory ion channels TRPC3 and TRPC7 could be the potential therapeutic targets in pancreatic cancer and TRPC3 might be involved in dysregulating mitochondrial functions during PAAD genesis