Selected characteristics of Cases and Controls in WCHS with POLG-CAG repeat polymorphism.

1<p>Chi-square test.</p>2<p>t-test.</p

Odd ratios of POLG-CAG repeat polymorphism in WCHS.

1<p>Adjusted for age, age at menarche, age at first full term pregnancy, menopausal status, first degree family history of breast cancer, and BMI.</p

Representative electopherogram of normal CAG (10∶10), contraction (6∶10) and expansion (10∶13) of POLG.

<p>Representative electopherogram of normal CAG (10∶10), contraction (6∶10) and expansion (10∶13) of POLG.</p

Additional file 2: Figure S1. of Frequency of breast cancer subtypes among African American women in the AMBER consortium

Receiver operating characteristic (ROC) curve in 250 HER2-negative luminal cases (A) and 309 luminal cases (B) regardless of HER2 status, using Ki67 expression to identify PAM50-based luminal B cases. A Ki67 threshold of 7.6% among HER2-negative luminal cases (A) and 7.1% among all luminal cases (B) maximized sensitivity and specificity for identifying PAM50-based luminal B tumors. AUC, area under the curve. (DOCX 43 kb

Additional file 4: Figure S2. of Frequency of breast cancer subtypes among African American women in the AMBER consortium

Kernel density plots showing the distribution of Ki67 and PR expression (A and B, respectively) in PAM50-defined luminal A (n = 159) and luminal B (n = 91) subtypes. Analyses were restricted to IHC-based HER2-negative tumors. Vertical lines indicate an 8% threshold for Ki67 (A) and a 20% threshold for PR (B). (DOCX 56 kb

Additional file 3: Table S1. of Frequency of breast cancer subtypes among African American women in the AMBER consortium

Classification of luminal breast cancer cases using data from medical records in the AMBER consortium. (DOCX 12 kb

Additional file 5: Table S2. of Frequency of breast cancer subtypes among African American women in the AMBER consortium

Effect of raising the Ki67 threshold on the performance of the IHC-based luminal classification scheme. (DOCX 12 kb

Additional file 1: of Frequency of breast cancer subtypes among African American women in the AMBER consortium

Supplementary methods. (DOCX 15 kb