"Антропологизация" как фактор проблематизации в познании

Рассматривается процесс антропологизации познания через способы проблематизации знания. Делается вывод, что онтологический плюрализм требует соответствующего способа совмещения разных начал, проблематизация которых осуществляется на основе способностей человека познавать мир. Принцип дополнительности и антропный принцип выражают указанные особенности проблематизации знаний человека

Совершенствование процесса управления дебиторской задолженностью на предприятии

Объектом исследования является дебиторская задолженность предприятия ОА «Сибкабель». Цель работы - совершенствование процесса управления дебиторской задолженностью на предприятии. В процессе исследования проводился анализ объема, состава, структуры и динамики дебиторской задолженности за 2014 г ОА «Сибкабель». В результате исследования выявлено, что показатель оборачиваемости дебиторской задолженности низкий и предприятие использует не эффективную систему предоставления отсрочка платежа. Предприятию были предложены рекомендации по управлению дебиторской задолженности, результате которых наблюдается улучшение финансового положения предприятия.The object of this study is to receivables enterprise OA "Sibkabel". Purpose - improving accounts receivable management process across the enterprise. The study was conducted analysis of the scope, composition, structure and dynamics of accounts receivable for 2014, OA 'Sibkabel ". The study revealed that the rate of receivables turnover is low and the company does not use an effective system of deferred payment. FME were offered recommendations for the management of accounts receivable, which resulted in the financial situation of the company have improved

On the Deformation of Dendrites During Directional Solidification of a Nickel-Based Superalloy

International audienc

Gravity effect on thermal-solutal convection during solidification revealed by four-dimensional synchrotron imaging with compositional mapping

The effect of gravity on thermo-solutal convection and its impact on solidification dynamics of an Al-15 wt%Cu alloy were studied using high speed synchrotron tomography. A method for mapping the composition of the solidifying samples was developed, enabling three-dimensional quantification of the time evolved solute concentration and dendrite morphology. Differences in solute segregation, dendrite morphology and fragmentation between upwards and downwards solidification were identified, which were attributed to buoyancy-modulated thermal-solutal convection

Relationship between solidification microstructure and hot cracking susceptibility for continuous casting of low-carbon and high-strength low-alloyed steels: A phase-field study

© The Minerals, Metals & Materials Society and ASM International 2013Hot cracking is one of the major defects in continuous casting of steels, frequently limiting the productivity. To understand the factors leading to this defect, microstructure formation is simulated for a low-carbon and two high-strength low-alloyed steels. 2D simulation of the initial stage of solidification is performed in a moving slice of the slab using proprietary multiphase-field software and taking into account all elements which are expected to have a relevant effect on the mechanical properties and structure formation during solidification. To account for the correct thermodynamic and kinetic properties of the multicomponent alloy grades, the simulation software is online coupled to commercial thermodynamic and mobility databases. A moving-frame boundary condition allows traveling through the entire solidification history starting from the slab surface, and tracking the morphology changes during growth of the shell. From the simulation results, significant microstructure differences between the steel grades are quantitatively evaluated and correlated with their hot cracking behavior according to the Rappaz-Drezet-Gremaud (RDG) hot cracking criterion. The possible role of the microalloying elements in hot cracking, in particular of traces of Ti, is analyzed. With the assumption that TiN precipitates trigger coalescence of the primary dendrites, quantitative evaluation of the critical strain rates leads to a full agreement with the observed hot cracking behavior. © 2013 The Minerals, Metals & Materials Society and ASM International

(Phospho)proteomic profiling of microsatellite unstable CRC cells reveals alterations in nuclear signaling and cholesterol metabolism caused by frameshift mutation of NMD regulator UPF3A

DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs) are affected, tumors accumulate frameshift mutations and premature termination codons (PTC) potentially leading to truncated proteins. Nonsense-mediated RNA decay (NMD) can degrade PTC-containing transcripts and protect from such faulty proteins. As it also regulates normal transcripts and cellular physiology, we tested whether NMD genes themselves are targets of MSI frameshift mutations. A high frequency of cMNR frameshift mutations in the UPF3A gene was found in MSI CRC cell lines (67.7%), MSI colorectal adenomas (55%) and carcinomas (63%). In normal colonic crypts, UPF3A expression was restricted to single chromogranin A-positive cells. SILAC-based proteomic analysis of KM12 CRC cells revealed UPF3A-dependent down-regulation of several enzymes involved in cholesterol biosynthesis. Furthermore, reconstituted UPF3A expression caused alterations of 85 phosphosites in 52 phosphoproteins. Most of them (38/52, 73%) reside in nuclear phosphoproteins involved in regulation of gene expression and RNA splicing. Since UPF3A mutations can modulate the (phospho)proteomic signature and expression of enzymes involved in cholesterol metabolism in CRC cells, UPF3A may influence other processes than NMD and loss of UPF3A expression might provide a growth advantage to MSI CRC cells

On the Deformation of Dendrites During Directional Solidification of a Nickel-Based Superalloy

Abstract: Synchrotron X-ray imaging has been used to examine in situ the deformation of dendrites that takes place during the solidification of a nickel-based superalloy. By combining absorption and diffraction contrast imaging, deformation events could be classified by their localization and permanence. In particular, a deformation mechanism arising from thermal contraction in a temperature gradient was elucidated through digital image correlation. It was concluded that this mechanism may explain the small misorientations typically observed in single crystal castings