7 research outputs found
Ratio of experiment data to the calculation results of burst strength.
<p>Ratio of experiment data to the calculation results of burst strength.</p
Comparison of burst strength calculation results with test data.
<p>Comparison of burst strength calculation results with test data.</p
Relationship between the ratio of test data to calculations and the radius-thickness ratio (D/t).
<p>Relationship between the ratio of test data to calculations and the radius-thickness ratio (D/t).</p
Highly Stable Graphene-Based Nanocomposite (GO–PEI–Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects
Various
silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites
(GO–Ag) have received increasing attention owing to their antimicrobial
activity and biocompatibility; however, their aggregation in physiological
solutions and the generally complex synthesis methods warrant improvement.
This study aimed to synthesize a polyethyleneimine (PEI)-modified
and AgNP-decorated GO nanocomposite (GO–PEI–Ag) through
a facile approach through microwave irradiation without any extra
reductants and surfactants; its antimicrobial activity was investigated
on Gram-negative/-positive bacteria (including drug-resistant bacteria)
and fungi. Compared with GO–Ag, GO–PEI–Ag acquired
excellent stability in physiological solutions and electropositivity,
showing substantially higher antimicrobial efficacy. Moreover, GO–PEI–Ag
exhibited particularly excellent long-term effects, presenting no
obvious decline in antimicrobial activity after 1 week storage in
physiological saline and repeated use for three times and the lasting
inhibition of bacterial growth in nutrient-rich culture medium. In
contrast, GO–Ag exhibited a >60% decline in antimicrobial
activity after storage. Importantly, GO–PEI–Ag effectively
eliminated adhered bacteria, thereby preventing biofilm formation.
The primary antimicrobial mechanisms of GO–PEI–Ag were
evidenced as physical damage to the pathogen structure, causing cytoplasmic
leakage. Hence, stable GO–PEI–Ag with robust, long-term
antimicrobial activity holds promise in combating public-health threats
posed by drug-resistant bacteria and biofilms