BODIPY dyads and triads: synthesis, optical, electrochemical and transistor properties

A series of D–A dyads and D–A–D triads molecular systems based on triphenylamine and 9-ethyl-carbarzole as donor (D) and BODIPY as acceptor (A) has been designed and synthesized. The optoelectronic properties including optical, electrochemical, and charge carrier mobility of these molecules have been investigated. We found that the D–A–D triads exhibited broader absorption, raising the HOMO energy levels and increase hole carrier mobilities. Analysis surface morphology revealed that BODIPY containing carbazole demonstrated smooth film and no macro phase aggregation was observed upon thermal annealing

Strategic purchasing and health system efficiency: A comparison of two financing schemes in Thailand.

Strategic purchasing is an essential health financing function. This paper compares the strategic purchasing practices of Thailand's two tax-financed health insurance schemes, the Universal Coverage Scheme (UCS) and the Civil Servant Medical Benefit Scheme (CSMBS), and identifies factors contributing to successful universal health coverage outcomes by analysing the relationships between the purchaser and government, providers and members. The study uses a cross-sectional mixed-methods design, including document review and interviews with 56 key informants. The Comptroller General Department (CGD) of Ministry of Finance manages CSMBS as one among civil servant welfare programmes. Their purchasing is passive. Fee for service payment for outpatient care has resulted in rapid cost escalation and overspending of their annual budget. In contrast, National Health Security Office (NHSO) manages purchasing for UCS, which undertakes a range of strategic purchasing actions, including applying closed ended provider payment, promoting primary healthcare's gate keeping functions, exercising collective purchasing power and engaging views of members in decision making process. This difference in purchasing arrangements resulted in expenditure per CSMBS member being 4 times higher than UCS in 2014. The governance of the purchaser organization, the design of the purchasing arrangements including incentives and use of information, and the institutional capacities to implement purchasing functions are essential for effective strategic purchasing which can improve health system efficiency as a whole

Molecular Designs for Charge and Ion Transporting Materials

High temperature anhydrous proton conducting polymer and optoelectronic based organic compounds are promising materials for use in renewable energy applications. Fundamental understanding of better proton and charge transport properties are required to achieve desirable alternative energy materials. In this thesis, we focus on molecular design, synthetic approaches, and understanding structure-property relationships to improved proton conductivity and optoelectronic properties. In proton conducting polymers, we tethered N-heterocycles (imidazole and benzotriazole) as proton carrier in two polymer systems; dendritic-linear block copolymers and helical polymers. Dendritic-linear block copolymers functionalized with imidazole and benzotriazole are designed to self-organize into nano scale assemblies that would increase local charge density and enhance proton conductivity. We found that microphase separation within disordered structure of imidazole-based block copolymers could relate to the higher conductivity compared to benzotriazole-based block copolymers that do not have phase separation in the same length scale. In the second system, we have focused on effect of chirality on proton conductivity in helical polymer. We functionalized L-histidine and histamine on poly(phenylacetylene) and poly(4-vinylbenzoate). Poly(phenylacetylene) is known as dynamic helical polymer while poly(4-vinylbenzoate) is a random polymer. Effects of backbone chirality, side chains and doping acids on proton conductivity are evaluated in this work. We found that a single handed conformation of poly(phenylacetylene) bearing L-histidine can enhanced proton conductivity compared to those of containing histamine. Whereas, vinyl backbone, poly (4-vinylbenzoate) bearing L-histidine exhibited lower conductivity due to a higher T g of the polymer. Cyclopentadithiophene (CPDT) derivatives are often used as an active layer in optoelectronic devices. However, CPDT is known to have a low absorption at the lower energy band. To solve this issue, we proposed to change the conformation of heteroatom at the bridgehead. We incorporated ketone and imine functionalities at the bridgehead positions, anti and syn. We found that by changing heteroatom position to syn-position increased absorption intensity in the lower energy band. Incorporation of a ketone at anti-position provides good mobility of 0.003 cm 2 /Vs while, changing the ketone group at the syn-position significantly decrease charge mobility

Assessing the Potential of Gallic Acid and Methyl Gallate to Enhance the Efficacy of β-Lactam Antibiotics against Methicillin-Resistant <i>Staphylococcus aureus</i> by Targeting β-Lactamase: In Silico and In Vitro Studies

Methicillin-resistant Staphylococcus aureus (MRSA), a global health concern, has prompted research into antibiotic adjuvants as a potential solution. Although our group previously reported the enhancing effects of gallic acid (GA) and methyl gallate (MG) on penicillin G activity against MRSA, the synergistic potential with other β-lactam antibiotics and the underlying mechanism have not been fully explored. Therefore, this study primarily aimed to investigate the antibacterial synergism with β-lactam antibiotics through disc diffusion, checkerboard, and time–kill assays. The β-lactamase inhibition was also examined through both molecular modeling and in vitro experiments. Additionally, bacterial morphology changes were studied using a scanning electron microscopy (SEM). The results revealed that both GA and MG exhibited anti-MRSA activity and showed indifferent effects when combined with β-lactam antibiotics against methicillin susceptible S. aureus (MSSA). Interestingly, MG demonstrated synergism with only the β-lactamase-unstable antibiotics against MRSA with the lowest fractional inhibitory concentration (FIC) indexes of ≤3.75. However, GA and MG exhibited weak β-lactamase inhibition. Furthermore, GA, MG, and the combination with ampicillin induced the morphological changes in MRSA, suggesting a possible mechanism affecting the cell membrane. These findings suggest that MG could potentially serve as an adjunct to β-lactam antibiotics to combat MRSA infections

Electrospun Cyclodextrin/Poly(L-lactic acid) Nanofibers for Efficient Air Filter: Their PM and VOC Removal Efficiency and Triboelectric Outputs

In this work, PLLA and CD/PLLA nanofibers were fabricated using electrospinning and utilized as a particulate matter (PM) and volatile organic compounds (VOCs) filter. The electrospun PLLA and CD/PLLA were characterized with various techniques, including SEM, BET, FTIR, XRD, XPS, WCA, DSC, tensile strength testing, PM and VOCs removal efficiency, and triboelectric performance. The results demonstrated that the best air filter was 2.5 wt%CD/PLLA, which performed the highest filtration efficiencies of 96.84 &plusmn; 1.51% and 99.38 &plusmn; 0.43% for capturing PM2.5 and PM10, respectively. Its PM2.5 removal efficiency was 16% higher than that of pure PLLA, which were contributed by their higher surface area and porosity. These 2.5 wt%CD/PLLA nanofibers also exhibited the highest and the fastest VOC entrapment. For triboelectric outputs, the 2.5 wt%CD/PLLA-based triboelectric nanogenerator provided the highest electrical outputs as 245 V and 84.70 &mu;A. These give rise to a three-fold enhancement of electrical outputs. These results indicated that the 2.5 wt%CD/PLLA can improve surface charge density that could capture more PM via electrostatic interaction under surrounding vibration. Therefore, this study suggested that 2.5 wt%CD/PLLA is a good candidate for a multifunction nanofibrous air filter that offers efficient PM and VOC removal

Improved Performance of Ternary Solar Cells by Using BODIPY Triads

Two boron dipyrromethene (BODIPY) triads, namely BODIPY-1 and BODIPY-2, were synthesized and incorporated with poly-3-hexyl thiophene: (6,6)-phenyl-C61-butyric acid methyl ester (PCBM) P3HT:PCBM. The photovoltaic performance of BODIPY:P3HT:PCBM ternary solar cells was increased, as compared to the control binary solar cells (P3HT:PCBM). The optimized power conversion efficiency (PCE) of BODIPY-1:P3HT:PCBM was improved from 2.22% to 3.43%. The enhancement of PCE was attributed to cascade charge transfer, an improved external quantum efficiency (EQE) with increased short circuit current (Jsc), and more homogeneous morphology in the ternary blend

MOESM1 of BODIPY dyads and triads: synthesis, optical, electrochemical and transistor properties

Additional file 1. NMR spectroscopic data, FET and AFM measurements of BODIPY dyads and triads

The Synchronization of Electron Enricher and Electron Extractor as Ternary Composite Photoanode for Enhancement of DSSC Performance

This work developed a novel ternary composite photoanode of dye-sensitized solar cell (DSSC) composed of (i) N-, S-doped titanium dioxide with exposed {001} facet (N-, S-TiO2{001}), (ii) N-, S-doped reduced graphene oxide (N-, S-rGO), and (iii) commercial titanium dioxide (P25). The DSSC device fabricated with the ternary composite photoanode showed the greatest of power conversion efficiency (8.62%) compared to the device fabricated with P25 photoanode (3.20%). This enhancement was attributed to the synergistic effect of the N-, S-TiO2{001} and the N-, S-rGO, which act as an electron enricher and an electron extractor, respectively

Effective coverage of diabetes and hypertension: an analysis of Thailand's national insurance database 2016-2019.

OBJECTIVES: This study assesses effective coverage of diabetes and hypertension in Thailand during 2016-2019. DESIGN: Mixed method, analysis of National health insurance database 2016-2019 and in-depth interviews. SETTING: Beneficiaries of Universal Coverage Scheme residing outside Bangkok. PARTICIPANTS: Quantitative analysis was performed by acquiring individual patient data of diabetes and hypertension cases in the Universal Coverage Scheme residing outside bangkok in 2016-2019. Qualitative analysis was conducted by in-depth interview of 85 multi-stakeholder key informants to identify challenges. OUTCOMES: Estimate three indicators: detected need (diagnosed/total estimated cases), crude coverage (received health services/total estimated cases) and effective coverage (controlled/total estimated cases) were compared. Controlled diabetes was defined as haemoglobin A1C (HbA1C) below 7% and controlled hypertension as blood pressure below 140/90 mm Hg. RESULTS: Estimated cases were 3.1-3.2 million for diabetes and 8.7-9.2 million for hypertension. For diabetes, all indicators have shown slow improvement between 2016 and 2019 (67.4%, 69.9%, 71.9% and 74.7% for detected need; 38.7%, 43.1%, 45.1% and 49.8% for crude coverage and 8.1%, 10.5%, 11.8% and 11.7% for effective coverage). For hypertension, the performance was poorer for detection (48.9%, 50.3%, 51.8% and 53.3%) and crude coverage (22.3%, 24.7%, 26.5% and 29.2%) but was better for effective coverage (11.3%, 13.2%, 15.1% and 15.7%) than diabetes. Results were better for the women and older age groups in both diseases. Complex interplays between supply and demand side were a key challenge. Database challenges also hamper regular assessment of effective coverage. Sensitivity analysis when using at least three annual visits shows slight improvement of effective coverage. CONCLUSION: Effective coverage was low for both diseases, though improving in 2016-2019, especially among men and ัyounger populations. The increasing rate of effective coverage was significantly smaller than crude coverage. Health information systems limitation is a major barrier to comprehensive measurement. To maximise effective coverage, long-term actions should address primary prevention of non-communicable disease risk factors, while short-term actions focus on improving Chronic Care Model