4 research outputs found
Additional file 1 of Physical activity during pregnancy and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis
Supplementary Material 1
Comparative Study of Machine Learning-Based QSAR Modeling of Anti-inflammatory Compounds from Durian Extraction
Quantitative structure–activity
relationship (QSAR) analysis,
an in silico methodology, offers enhanced efficiency
and cost effectiveness in investigating anti-inflammatory activity.
In this study, a comprehensive comparative analysis employing four
machine learning algorithms (random forest (RF), gradient boosting
regression (GBR), support vector regression (SVR), and artificial
neural networks (ANNs)) was conducted to elucidate the activities
of naturally derived compounds from durian extraction. The analysis
was grounded in the exploration of structural attributes encompassing
steric and electrostatic properties. Notably, the nonlinear SVR model,
utilizing five key features, exhibited superior performance compared
to the other models. It demonstrated exceptional predictive accuracy
for both the training and external test datasets, yielding R2 values of 0.907 and 0.812, respectively; in
addition, their RMSE resulted in 0.123 and 0.097, respectively. The
study outcomes underscore the significance of specific structural
factors (denoted as shadow ratio, dipole z, methyl,
ellipsoidal volume, and methoxy) in determining anti-inflammatory
efficacy. Thus, the findings highlight the potential of molecular
simulations and machine learning as alternative avenues for the rational
design of novel anti-inflammatory agents
Extreme Mechanical Behavior of Nacre-Mimetic Graphene-Oxide and Silk Nanocomposites
Biological materials
have the ability to withstand extreme mechanical
forces due to their unique multilevel hierarchical structure. Here,
we fabricated a nacre-mimetic nanocomposite comprised of silk fibroin
and graphene oxide that exhibits hybridized dynamic responses arising
from alternating high-contrast mechanical properties of the components
at the nanoscale. Dynamic mechanical behavior of these nanocomposites
is assessed through a microscale ballistic characterization using
a 7.6 μm diameter silica sphere moving at a speed of approximately
400 m/s. The volume fraction of graphene oxide in these composites
is systematically varied from 0 to 32 vol % to quantify the dynamic
effects correlating with the structural morphologies of the graphene
oxide flakes. Specific penetration energy of the films rapidly increases
as the distribution of graphene oxide flakes evolves from noninteracting,
isolated sheets to a partially overlapping continuous sheet. The specific
penetration energy of the nanocomposite at the highest graphene oxide
content tested here is found to be significantly higher than that
of Kevlar fabrics and close to that of pure multilayer graphene. This
study evidently demonstrates that the morphologies of nanoscale constituents
and their interactions are critical to realize scalable high-performance
nanocomposites using typical nanomaterial constituents having finite
dimensions
THE DEVELOPMENT OF THE TECHNOLOGICAL BASES FOR OBTAINING AND PROCESSING OF THE BASE THERMOPLASTIC BUTADIEN-NITRIL ELASTOMERS
The object of investigation: the butadien-nitril rubber, polyvinylchloride, polystirol, polycarbonate, ABC-plastics, polyamide, acetylcellulose, polypropylene. The theoretical justification has been given, the mathematical model of the quality of the base materials, the mathematical model of optimization of the modified thermoplastic elastomers recipe have been developed, the influence of the fillers and plastificators of the different nature on the consumers properties of the base materials has been developed, the method of prognosing of the materials technological properties has been developed. Offered has been the method of the "dynamic" vulcanization, with the aid of which the base materials have been received, and it allows to reduce the time of the vulcanization by 5 times and to reduce the electric power consumption. The recipes of the cast compositions, posessing the improved values of the operating and consumer properties, the modes and the parameters of the processing of the base materials, the multiple use of the obtained alloys have been offered. The base polymer materials of the new type for casting under pressure have been introduced in practiceAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio