Surveillance city in a post 9/11 era

Surveillance City in A Post 9/11 Era is a thesis investigation trying to understand our privacy, perceived safety and public realm in the large context of evolving terrorism worldwide by promoting a conversation about how surveillance would change our city, our new relationship with the city under surveillance, and how people will live with surveillance in the future. Phase one seeks to understand terrorism and terrorist attack in general, and the opportunities and limitations of the existing security design strategies that have been implemented by US government. In phase two, a specific investigation direction is determined and a series of perceived safety assessment are conducted in order to understand terrorism target, criteria of perceiving safety in public spaces, and the constrains and opportunities of the site to develop appropriate future strategies. Phase three is focused on the long-term discussion triggered by the extensive use of surveillance camera in New York after 9/11. A radical city mode, SURVEILLANCE CITY , is provoked at the end of this investigation to promote a conversation to better understand how surveillance would change our city, the way we live and our new relationship with the city in the large context of evolving terrorism worldwide

Polysaccharides isolated from Morinda officinalis How roots inhibits cyclophosphamide-induced leukopenia in mice

Purpose: To investigate the optimum parameters for extracting polysaccharides from Morinda officinalis How (MOP), and explore their inhibitory effects on leukopenia in mice.Methods: Orthogonal design was performed to investigate the optimum parameters for extracting MOP. A leukopenia mouse model was established by injection of cyclophosphamide (CTX) for three days. Thereafter, MOP (100, 200 and 400 mg/kg) was administered orally for 10 days. Furthermore, blood cells (leukocytes, neutrophil, lymphocyte and mononuclear cell) were analyzed, while serum IL-3 and IL- 6 were determined by ELISA. The thymus and spleen of the mice were separated and weighed to determine viscera indices.Results: Orthogonal design showed that the influence order of the four factors was extraction times (C) > ratio of water to raw material (RWM, D) > extraction time (B) > extraction temperature (A). The optimum extraction parameters for MOP were: extraction temperature (80 °C), extraction duration (2 h), no. of extractions (3), and ratio of water to raw material (30 mL/g). Furthermore, the results indicate that MOP (100, 200 and 400 mg/kg) elevated the levels of leukocyte (p < 0.01), neutrophil (p < 0.01), lymphocyte (p < 0.01) and mononuclear cell (p < 0.01) in leukopenia mice. Besides, MOP (100, 200 and 400 mg/kg) also increased thymus (p < 0.01) and spleen (p < 0.05) indices and serum levels of IL-3 (p < 0.05) and IL-6 (p < 0.01).Conclusion: Orthogonal design is a good strategy for optimizing extraction parameters of MOP. Furthermore, MOP stimulated synthesis of leukocytes in CTX-induced leukopenia in mice. Thus, MOP is a potential adjunct for the treatment of tumors/cancers.Keywords: Morinda officinalis, Polyscacharide, Orthogonal design, Leukopenia, Thymus index, Spleen inde

A novel non-invasive brain stimulation technique: “Temporally interfering electrical stimulation”

For decades, neuromodulation technology has demonstrated tremendous potential in the treatment of neuropsychiatric disorders. However, challenges such as being less intrusive, more concentrated, using less energy, and better public acceptance, must be considered. Several novel and optimized methods are thus urgently desiderated to overcome these barriers. In specific, temporally interfering (TI) electrical stimulation was pioneered in 2017, which used a low-frequency envelope waveform, generated by the superposition of two high-frequency sinusoidal currents of slightly different frequency, to stimulate specific targets inside the brain. TI electrical stimulation holds the advantages of both spatial targeting and non-invasive character. The ability to activate deep pathogenic targets without surgery is intriguing, and it is expected to be employed to treat some neurological or psychiatric disorders. Recently, efforts have been undertaken to investigate the stimulation qualities and translation application of TI electrical stimulation via computational modeling and animal experiments. This review detailed the most recent scientific developments in the field of TI electrical stimulation, with the goal of serving as a reference for future research

Biosensing strategies for amyloid‐like protein aggregates

Protein aggregate species play a pivotal role in the pathology of various degenerative diseases. Their dynamic changes are closely correlated with disease progression, making them promising candidates as diagnostic biomarkers. Given the prevalence of degenerative diseases, growing attention is drawn to develop pragmatic and accessible protein aggregate species detection technology. However, the performance of current detection methods is far from satisfying the requirements of extensive clinical use. In this review, we focus on the design strategies, merits, and potential shortcomings of each class of detection methods. The review is organized into three major parts: native protein sensing, seed amplification, and intricate program, which embody three different but interconnected methodologies. To the best of our knowledge, no systematic review has encompassed the entire workflow, from the molecular level to the apparatus organization. This review emphasizes the feasibility of the methods instead of theoretical detection limitations. We conclude that high selectivity does play a pivotal role, while signal compilation, multilateral profiling, and other patient-oriented strategies (i.e. less invasiveness and assay speed) are also important

SMURF1 Attenuates Endoplasmic Reticulum Stress by Promoting the Degradation of KEAP1 to Activate NRF2 Antioxidant Pathway

Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins. Extreme activation of the UPR could also provoke maladaptive cell death. Previous reports have shown that NRF2 antioxidant signaling is activated by UPR and serves as noncanonical pathway to defense and reduce excessive ROS levels during ER stress. However, the mechanisms of regulating NRF2 signaling upon ER stress in glioblastoma have not been fully elucidated. Here we identify that SMURF1 protects against ER stress and facilitates glioblastoma cell survival by rewiring KEAP1-NRF2 pathway. We show that ER stress induces SMURF1 degradation. Knockdown of SMURF1 upregulates IRE1 and PERK signaling in the UPR pathway and prevents ER-associated protein degradation (ERAD) activity, leading to cell apoptosis. Importantly, SMURF1 overexpression activates NRF2 signaling to reduce ROS levels and alleviate UPR-mediated cell death. Mechanistically, SMURF1 interacts with and ubiquitinates KEAP1 for its degradation (NRF2 negative regulator), resulting in NRF2 nuclear import. Moreover, SMURF1 loss reduces glioblastoma cell proliferation and growth in subcutaneously implanted nude mice xenografts. Taken together, SMURF1 rewires KEAP1-NRF2 pathway to confer resistance to ER stress inducers and protect glioblastoma cell survival. ER stress and SMURF1 modulation may provide promising therapeutic targets for the treatment of glioblastoma

Study on atomization mechanisms and spray fragmentation characteristics of water and emulsion butachlor

Agricultural chemicals are commonly used to control pests and weeds, but cause pesticide waste problems. Oil-based emulsions are often used as pesticide formulations to improve pesticide utilization. In this study, the spray visualization experiment of the water and oil-based emulsion butachlor is carried out using an ST flat fan nozzle at 0.1–0.5 MPa pressure. The dimensionless method is used to analyze the difference in liquid sheet fragmentation morphology and disintegration process and the influence of different fragmentation methods on droplet size. It is found that the hydrophobic components in pesticide have a significant effect on the morphology and process of atomization fragmentation. When spray liquid is water, the liquid sheet breaks up into liquid ligaments due to the Rayleigh instability, then the ligaments break up into droplets. The side view of a liquid sheet is a large-amplitude wave disturbance. When the spray liquid is the emulsion butachlor, holes are generated on the liquid sheet, then the holes break up into droplets. The fragmentation method of emulsion spray is the perforation mechanism. Compared with water spray, the presence of the pesticide butachlor increases the droplet size and spray angle and improves the uniformity of droplet size distribution but reduces the breakup length. The spray angle shows a power law dependence of the Weber number with a power of 0.17 for all conditions tested here. At 0.3 MPa, DV50 increases 25%, and span decreases from 1.187 to 1.172. This study could provide reference for the addition of agricultural additives, the improvement of spray operation efficiency, and the establishment of spray fragmentation mechanism

Collaborative Design of Static and Vibration Properties of a Novel Re-Entrant Honeycomb Metamaterial

A novel re-entrant honeycomb metamaterial based on 3D-printing technology is proposed by introducing chiral structures into diamond honeycomb metamaterial (DHM), named chiral-diamond-combined honeycomb metamaterial (CDCHM), and has been further optimized using the assembly idea. Compared with the traditional DHM, the CDCHM has better performance in static and vibration isolation. The static and vibration properties of the DHM and CDCHM are investigated by experiments and simulations. The results show that the CDCHM has a higher load-carrying capacity than that of the DHM. In addition, the vibration isolation optimal design schemes of the DHM and CDCHM are examined by experiments and simulations. It is found that the vibration suppression of the CDCHM is also improved greatly. In particular, the optimization approach with metal pins and particle damping achieves a wider bandgap in the low-frequency region, which can strengthen the suppression of low-frequency vibrations. And the introduction of particle damping can not only design the frequency of the bandgap via the alteration of the dosage, but also enhance the damping of the main structure. This work presents a new design idea for metamaterials, which provides a reference for the collaborative design of the static and vibration properties of composite metamaterials

Social Group Architecture Based Distributed Ride-Sharing Service in VANET

Lots of traditional distributed ride-sharing services match vehicles with drivers and passengers geographic information only. When urban road congestion situation is particularly serious, such as Beijing's rush hour, the waiting time for the passengers is too long which affects the quality of the service. So we propose a distributed ride-sharing service based on dual Social Group Architecture (SGA). We divide the service into Drivers Social Group Architecture (DSGA) message and Vehicles Social Group Architecture (VSGA) message. Vehicles generate dual SGA messages to complete ride-sharing service. DSGA messages focus on the relation between drivers and passengers. We make a basic geometry matching by generating the DSGA messages. VSGA messages figure out the traffic conditions through a multilevel detection. After generating VSGA messages, the final matching strategy is processed. The low level detection is finished by the limited neighbors to decrease the network consume. Dual SGA messages shorten the waiting time for the passengers and avoid traffic jams. Analysis shows that our scheme enhances the ride-sharing service quality and robust