Benzene health risk assessment for neurological disorders of gas station employees in Rayong Province, Thailand

Background. The main job of employees working in the area of fuel service stations is to provide refueling services to customers. Therefore, operators at petrol stations may be exposed to chemicals for long periods, potentially affecting their health in nervous system. Objectives. This study aims to assess the risk of benzene exposure to the nervous system in gas station operators. Data were collected from 100 fuel service personnel working at fuel dispensers and 100 employees working outside fuel dispensers, accounting to 200 cases. Material and methods. Data were collected using interview questionnaires. Urine samples were used for the analysis of t,t-muconic acid. Results. The results showed that t,t-muconic acid concentration is 431.23 ± 233.69 μg/g.cr (449.28 ± 213.32 μg/g.cr at fuel dispensers vs 413.18 ± 252.20 μg/g.cr outside fuel dispensers). The risk characterization results showed that most of the risks were at level 1 (low risk), as observed in 108 people (54.0%). The results of the analysis of the relationship between t,t-muconic acid concentrations classified by 3 levels of percentile and neurological disorders of the study group, the results showed that there was a statistically significant relationship (p-value <0.05). Conclusion. Therefore, the benzene neurotoxic risk assessment model could be utilized in field practice

Time to Update and Quantitative Changes in the Results of Cochrane Pregnancy and Childbirth Reviews

BACKGROUND: The recommended interval between updates for systematic reviews included in The Cochrane Library is 2 years. However, it is unclear whether this interval is always appropriate. Whereas excessive updating wastes time and resources, insufficient updating allows out-of-date or incomplete evidence to guide clinical decision-making. We set out to determine, for Cochrane pregnancy and childbirth reviews, the frequency of updates, factors associated with updating, and whether updating frequency was appropriate. METHODOLOGY/PRINCIPAL FINDINGS: Cochrane pregnancy and childbirth reviews published in Issue 3, 2007 of the Cochrane Database of Systematic Reviews were retrieved, and data were collected from their original and updated versions. Quantitative changes were determined for one of the primary outcomes (mortality, or the outcome of greatest clinical significance). Potential factors associated with time to update were assessed using the Cox proportional hazard model. Among the 101 reviews in our final sample, the median time before the first update was 3.3 years (95% CI 2.7-3.8). Only 32.7% had been updated within the recommended interval of 2 years. In 75.3% (76/101), a median of 3 new trials with a median of 576 additional participants were included in the updated versions. There were quantitative changes in 71% of the reviews that included new trials (54/76): the median change in effect size was 18.2%, and the median change in 95% CI width was 30.8%. Statistical significance changed in 18.5% (10/54) of these reviews, but conclusions were revised in only 3.7% (2/54). A shorter time to update was associated with the same original review team at updating. CONCLUSIONS/SIGNIFICANCE: Most reviews were updated less frequently than recommended by Cochrane policy, but few updates had revised conclusions. Prescribed time to update should be reconsidered to support improved decision-making while making efficient use of limited resources

Cold Exposure and Health Effects Among Frozen Food Processing Workers in Eastern Thailand

Frozen food processing workers work under a cold environment which can cause several adverse health effects.This study explored factors affecting workers' health in the frozen food industry in Thailand. Participants comprised 497 workers exposed to a cold working environment and 255 office workers who served as the controls. Data were collected by a survey on the work environment, and the interview of workers for abnormal symptoms. The exposed group had the following characteristics: 52.7% male, overall average age of 27 (SD 6.6) years old, attained elementary education (Grade 4 and Grade 6) (54.1%), married (48.9%), smokers (21.3%), alcohol consumption (31.0%), duration of work was between 1 and 5 years (65.2%), working 6 days a week (82.7%), 1–5 hours of overtime per week (33.8%), office workers (33.9%); work category: sizing (6.9%), peeling (28.3%) dissecting (22.2%), and in the warehouse (8.6%). The temperature in the work environment ranged from 17.2°C to 19.2°C in most sections, −18.0°C in the warehouse, and 25°C in the office areas. Warehouse workers had more abnormal symptoms than controls including repeated pain in the musculoskeletal system (OR 11.9; 95% CI 6.12–23.45), disturbance throughout the body (OR 4.60; 95% CI 2.00–10.56), respiratory symptoms (OR 9.73; 95% CI 3.53–26.80), episodic finger symptoms (OR 13.51; 95% CI 5.17–35.33). The study results suggest that workers' health should be monitored especially with regard to back and muscle pain, respiratory symptoms, episodic finger symptoms, and cardiovascular symptoms. Health promotion campaigns such as antismoking and reduction of alcohol consumption should be established because smoking and alcohol consumption are contributing factors to the pathogenesis of Raynaud's phenomenon and peripheral vascular disorders such as hypertension and heart disease

Neuropsychological Symptoms among Workers Exposed to Toluene and Xylene in Two Paint Manufacturing Factories in Eastern Thailand

The study analyzed the exposure factors that may lead to neuropsychological symptoms among 92 workers who were exposed to xylene and toluene and 100 workers who were not exposed to the solvents. The airborne concentration of xylene and toluene was evaluated with personal passive badges. The levels of methyl hippuric acid and hippuric acid in urine were assessed, and interviews were performed to observe the neuropsychological symptoms that may result from exposure to the solvents. The result showed that the average concentration for the exposed group of xylene in the paint company working environment was 2.7 (SD = 2.4) ppm and the average concentration of toluene was 9.5 (SD = 10.4) ppm. The average level of methyl hippuric acid in urine was 78 (SD = 74.7) mg/g creatinine. Factors that affected the neuropsychological symptoms included the following. (1) The impact of age: the risk (adjusted odds ratio) for getting psychosomatic symptoms in persons over 40 and exposed to xylene was 9.5 and the aOR of those exposed to toluene was 8.3. (2) The impact of not providing personal protective equipment was found to be sleep disturbance; it was found that the aOR of those exposed to xylene was 3.9, and the aOR of those exposed to toluene was 4.4. In summary, periodic examination of workers by occupational physician is needed for detection of early neuropsychological effects, especially psychosomatic symptoms, and sleep disturbances

Characteristics of updated reviews at first update period (101 reviews).

<p>*For 76 reviews that included new trials.</p

Time to first update of the 101 updated reviews, by review team.

<p>Time to first update of the 101 updated reviews, by review team.</p

Flow diagram of selection of reviews for analysis.

<p>Flow diagram of selection of reviews for analysis.</p

Characteristics of updated reviews that included additional trials at first update (76 reviews).

<p>Characteristics of updated reviews that included additional trials at first update (76 reviews).</p

Kaplan–Meier curves with 95% confidence interval for sample of 101 reviews at first update.

<p>Kaplan–Meier curves with 95% confidence interval for sample of 101 reviews at first update.</p

Kaplan–Meier curves for reviews with and without additional trials at first update.

<p>Kaplan–Meier curves for reviews with and without additional trials at first update.</p