30 research outputs found

    Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review

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    Through pharmacological activity research, an increasing number of natural products and their derivatives are being recognized for their therapeutic value. In recent years, studies have been conducted on Corydalis yanhusuo W.T. Wang, a valuable medicinal herb listed in the Chinese Pharmacopoeia. Protopine, one of its components, has also become a research hotspot. To illustrate the identification, metabolism, and broad pharmacological activity of protopine and the botanical preparations containing it for further scientific studies and clinical applications, an in-depth and detailed review of protopine is required. We collected data on the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine from 1986 to 2021 from the PubMed database using “protopine” as a keyword. It has been shown that protopine as an active ingredient of many botanical preparations can be rapidly screened and quantified by a large number of methods (such as the LC-ESI-MS/MS and the TLC/GC-MS), and the possible metabolic pathways of protopine in vivo have been proposed. In addition, protopine possesses a wide range of pharmacological activities such as anti-inflammatory, anti-platelet aggregation, anti-cancer, analgesic, vasodilatory, anticholinesterase, anti-addictive, anticonvulsant, antipathogenic, antioxidant, hepatoprotective, neuroprotective, and cytotoxic and anti-proliferative activities. In this paper, the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine are reviewed in detail to lay a foundation for further scientific research and clinical applications of protopine

    A novel method for Jinnan cattle individual classification based on deep mutual learning

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    As the core technology of precision animal husbandry, efficient and rapid identification of Jinnan cattle individuals can promote the scale, informatization and refinement of breeding, which is very necessary for the development of animal husbandry at this stage. However, the traditional livestock individual recognition method based on ear tag is labour-consuming, time-consuming, inefficient, easy to wear and limited by the recognition distance, and the accuracy is also very low. In order to solve this problem, a new method of Jinnan cattle individual recognition based on deep mutual learning is proposed by using the non-contact image recognition method. Two student networks are designed. They supervise each other and complete the task together. Their efficiency can be higher than that of a strong teacher network. Through this method, the individual recognition performance of Jinnan cattle is also enhanced. The experimental results verify the effectiveness of the method of deep mutual learning. Consult and learn from the peer network are used to improve generalization, so as to improve model recognition performance. Finally, the accuracy is 99.3% on the Jinnan cattle individual dataset established in this paper. The application of the contactless cattle individual recognition method in the farm is of great significance

    Secure communication based on quantized synchronization of chaotic neural networks under an event-triggered strategy

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    This article presents a secure communication scheme based on the quantized synchronization of master-slave neural networks under an event-triggered strategy. First, a dynamic event-triggered strategy is proposed based on a quantized output feedback, for which a quantized output feedback controller is formed. Second, theoretical criteria are derived to ensure the bounded synchronization of master-slave neural networks. With these criteria, an explicit upper bound is given for the synchronization error. Sufficient conditions are also provided on the existence of quantized output feedback controllers. A Chua's circuit is chosen to illustrate the effectiveness of our theoretical results. Third, a secure communication scheme is presented based on the synchronization of master-slave neural networks by combining the basic principle of cryptology. Then, a secure image communication is studied to verify the feasibility and security performance of the proposed secure communication scheme. The impact of the quantization level and the event-triggered control (ETC) on image decryption is investigated through experiments

    Minimal leader selection in general linear multi-agent systems with switching topologies : leveraging submodularity ratio

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    In multi-agent systems with leader-follower dynamics, choosing a subset of agents as leaders is a critical step in achieving the desired coordination performance. In this study, by considering consensus tracking for general linear multi-agent systems under switching topologies, we address the problem of selecting a minimum-size set of leaders by leveraging the submodularity ratio. First, using the dwell time technique, a criterion is derived to ensure that the states of all agents can converge to a reference trajectory that is directly tracked by each leader. Second, exploiting the derived consensus tracking criterion, the metrics with a structure of the Euclidean distance between specific vectors and the space spanned by an iteratively updated matrix are established to identify a set of leaders, and then the corresponding bound of the submodularity ratio is proposed. Third, combining the derived criterion and the constructed metrics, a leader selection scheme is presented together with three polynomial-time algorithms, and the related provable optimality bound of each algorithm can be obtained by leveraging the proposed bound of the submodularity ratio. Finally, illustrative examples are provided to verify the effectiveness of the proposed leader selection scheme

    The Effect of Coronavirus 2019 Disease Control Measures on the Incidence of Respiratory Infectious Disease and Air Pollutant Concentrations in the Yangtze River Delta Region, China

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    The Yangtze River Delta is one of the top five Chinese regions affected by COVID-19, as it is adjacent to Hubei Province, where COVID-19 first emerged. We investigated the impact of COVID-19 non-pharmaceutical interventions (NPIs) on changes in respiratory infectious diseases (RIDs) incidence and air quality in the Yangtze River Delta by constructing two proportional tests and fitting ARIMA and linear regression models. Compared with the pre-COVID-19 period, the average monthly incidence of seven RIDs decreased by 37.80% (p < 0.001) and 37.11% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 20.39% (p < 0.001) and 22.86% (p < 0.001), respectively, in Zhejiang. Similarly, compared with the pre-COVID-19 period, the monthly overall concentrations of six air pollutants decreased by 12.7% (p = 0.003) and 18.79% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 12.85% (p = 0.008) and 15.26% (p = 0.001), respectively, in Zhejiang. Interestingly, no significant difference in overall incidence of RIDs and concentrations of air quality was shown between the COVID-19 period and the post-vaccination period in either Shanghai or Zhejiang. This study provides additional evidence that the NPIs measures taken to control COVID-19 were effective in improving air quality and reducing the spread of RIDs. However, a direct causal relationship has not been established

    Analysis of Retinal Microstructure in Eyes with Dissociated Optic Nerve Fiber Layer (DONFL) Appearance following Idiopathic Macular Hole Surgery: An Optical Coherence Tomography Study

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    (1) Purpose: This study aimed to evaluate morphological changes of the retina in eyes with dissociated optic nerve fiber layer (DONFL) appearance following internal limiting membrane (ILM) peeling for full-thickness idiopathic macular hole (IMH) on spectral-domain optical coherence tomography (SD-OCT). (2) Methods: We retrospectively analyzed 39 eyes of 39 patients with type 1 macular hole closure after a vitrectomy with ILM peeling procedure at a six-month minimum postoperative follow-up. The retinal thickness maps and cross-sectional OCT images were obtained from a clinical OCT device. The cross-sectional area of the retinal nerve fiber layer (RNFL) on cross-sectional OCT images was manually measured by ImageJ software. (3) Results: The inner retinal layers (IRLs) thickness thinned down much more in the temporal quadrant than in nasal quadrants at 2 and 6 months postoperatively (p < 0.001). However, the cross-sectional area of the RNFL did not change significantly at 2 and 6 months postoperatively (p > 0.05) when compared to preoperative data. In addition, the thinning of the IRL did not correlate with the best-corrected visual acuity (BCVA) at 6 months postoperatively. (4) Conclusions: The thickness of the IRL decreased in eyes with a DONFL appearance after ILM peeling for IMH. The thickness of the IRL decreased more in the temporal retina than in the nasal retina, but the change did not affect BCVA during the 6 months after surgery
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