Charmless Two-body B(Bs)→VPB(B_s)\to VP decays In Soft-Collinear-Effective-Theory

We provide the analysis of charmless two-body $B\to VP$ decays under the framework of the soft-collinear-effective-theory (SCET), where $V(P)$ denotes a light vector (pseudoscalar) meson. Besides the leading power contributions, some power corrections (chiraly enhanced penguins) are also taken into account. Using the current available $B\to PP$ and $B\to VP$ experimental data on branching fractions and CP asymmetry variables, we find two kinds of solutions in $\chi^2$ fit for the 16 non-perturbative inputs which are essential in the 87 $B\to PP$ and $B\to VP$ decay channels. Chiraly enhanced penguins can change several charming penguins sizably, since they share the same topology. However, most of the other non-perturbative inputs and predictions on branching ratios and CP asymmetries are not changed too much. With the two sets of inputs, we predict the branching fractions and CP asymmetries of other modes especially $B_s\to VP$ decays. The agreements and differences with results in QCD factorization and perturbative QCD approach are analyzed. We also study the time-dependent CP asymmetries in channels with CP eigenstates in the final states and some other channels such as $\bar B^0/B^0\to\pi^\pm\rho^\mp$ and $\bar B_s^0/B_s^0\to K^\pm K^{*\mp}$. In the perturbative QCD approach, the $(S-P)(S+P)$ penguins in annihilation diagrams play an important role. Although they have the same topology with charming penguins in SCET, there are many differences between the two objects in weak phases, magnitudes, strong phases and factorization properties.Comment: 34 pages, revtex, 2 figures, published at PR

Is f1(1420)f_1(1420) the partner of f1(1285)f_1(1285) in the 3P1^3P_1 qqˉq\bar{q} nonet?

Based on a $2\times 2$ mass matrix, the mixing angle of the axial vector states $f_1(1420)$ and $f_1(1285)$ is determined to be $51.5^{\circ}$, and the theoretical results about the decay and production of the two states are presented. The theoretical results are in good agreement with the present experimental results, which suggests that $f_1(1420)$ can be assigned as the partner of $f_1(1285)$ in the $^3P_1$ $q\bar{q}$ nonet. We also suggest that the existence of $f_1(1510)$ needs further experimental confirmation.Comment: Latex, 6 pages, to be published in Chin. Phys. let

1H-Benzimidazole-2(3H)-thione

The asymmetric unit of the title compound, C7H6N2S, contains one half-mol­ecule; the C and S atoms of the C=S group lie on a crystallographic mirror plane. In the crystal structure, inter­molecular N—H⋯S hydrogen bonds link the mol­ecules

Research progress of diabetic retinopathy and gut microecology

According to the prediction of the International Diabetes Federation, global diabetes mellitus (DM) patients will reach 783.2 million in 2045. The increasing incidence of DM has led to a global epidemic of diabetic retinopathy (DR). DR is a common microvascular complication of DM, which has a significant impact on the vision of working-age people and is one of the main causes of blindness worldwide. Substantial research has highlighted that microangiopathy and chronic low-grade inflammation are widespread in the retina of DR. Meanwhile, with the introduction of the gut-retina axis, it has also been found that DR is associated with gut microecological disorders. The disordered structure of the GM and the destruction of the gut barrier result in the release of abnormal GM flora metabolites into the blood circulation. In addition, this process induced alterations in the expression of various cytokines and proteins, which further modulate the inflammatory microenvironment, vascular damage, oxidative stress, and immune levels within the retina. Such alterations led to the development of DR. In this review, we discuss the corresponding alterations in the structure of the GM flora and its metabolites in DR, with a more detailed focus on the mechanism of gut microecology in DR. Finally, we summarize the potential therapeutic approaches of DM/DR, mainly regulating the disturbed gut microecology to restore the homeostatic level, to provide a new perspective on the prevention, monitoring, and treatment of DR

4-[(E)-(2-Methoxy­phen­yl)imino­meth­yl]-N,N-dimethyl­aniline

In the title compound, C16H18N2O, the dihedral angle between the benzene rings is 38.5 (2)°. The crystal packing is stabilized by weak C—H⋯N and C—H⋯O inter­actions and aromatic π–π stacking [centroid–centroid separations = 3.620 (5) and 3.546 (4) Å]

Cinnamyl 8-meth­oxy-2-oxo-2H-chromene-3-carboxyl­ate

In the crystal structure of the title compound, C20H16O5, the mol­ecule assumes an E configuration with the benzene ring and chromenecarboxyl group located on opposite ends of the C=C double bond. The chromene ring system and benzene ring are oriented at a dihedral angle of 74.66 (12)°. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure

Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease

<p>Abstract</p> <p>Background</p> <p>Toll-like receptor 2 (<it>TLR2</it>) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and functionally is involved in the microglia-mediated inflammatory response and amyloid-β clearance. The -196 to -174 del polymorphism affects the <it>TLR2 </it>gene and alters its promoter activity.</p> <p>Methods</p> <p>We recruited 800 unrelated Northern Han Chinese individuals comprising 400 late-onset AD (LOAD) patients and 400 healthy controls matched for gender and age. The -196 to -174 del polymorphism in the <it>TLR2 </it>gene was genotyped using the polymerase chain reaction (PCR) method.</p> <p>Results</p> <p>There were significant differences in genotype (P = 0.026) and allele (P = 0.009) frequencies of the -196 to -174 del polymorphism between LOAD patients and controls. The del allele was associated with an increased risk of LOAD (OR = 1.31, 95% CI = 1.07-1.60, Power = 84.9%). When these data were stratified by apolipoprotein E (<it>ApoE</it>) ε4 status, the observed association was confined to <it>ApoE </it>ε4 non-carriers. Logistic regression analysis suggested an association of LOAD with the polymorphism in a recessive model (OR = 1.64, 95% CI = 1.13-2.39, Bonferroni corrected P = 0.03).</p> <p>Conclusions</p> <p>Our data suggest that the -196 to -174 del/del genotype of <it>TLR2 </it>may increase risk of LOAD in a Northern Han Chinese population.</p