Urban Land Supply, Urban Growth, and Housing Prices in China

Ph.DDOCTOR OF PHILOSOPH

Immunogenicity and therapeutic effects of a Mycobacterium tuberculosis rv2190c DNA vaccine in mice

The Excel data file [FOLT] Figshare, [DOI: 10.6084/m9.figshare.4668148 and https://figshare.com/s/bd46c22986c673579bb6 ] includes all datasets supporting the conclusions of this article: IFN-Îł in spleen lymphocyte culture supernatants, IL-4 in spleen lymphocyte culture supernatants, CD4+ T cell subsets expressing intracellular IFN-Îł or IL-4, CFU in the lungs and spleens.. (XLS 143 kb

Multifield Ultralight Dark Matter

Ultralight dark matter (ULDM) is usually taken to be a single scalar field. Here we explore the possibility that ULDM consists of $N$ light scalar fields with only gravitational interactions. This configuration is more consistent with the underlying particle physics motivations for these scenarios than a single ultralight field. ULDM halos have a characteristic granular structure that increases stellar velocity dispersion and can be used as observational constraints on ULDM models. In multifield simulations, we find that inside a halo the amplitude of the total density fluctuations decreases as $1/\sqrt{N}$ and that the fields do not become significantly correlated over cosmological timescales. Smoother halos heat stellar orbits less efficiently, reducing the velocity dispersion relative to the single field case and thus weakening the observational constraints on the field mass. Analytically, we show that for $N$ equal-mass fields with mass $m$ the ULDM contribution to the stellar velocity dispersion scales as $1/(N m^3)$. Lighter fields heat the most efficiently and if the smallest mass $m_L$ is significantly below the other field masses the dispersion scales as $1/(N^2 m_L^3)$.Comment: 11 pages, 7 figures, to be submitted to PR

Downregulation of Brassica napus MYB69 (BnMYB69) increases biomass growth and disease susceptibility via remodeling phytohormone, chlorophyll, shikimate and lignin levels

MYB transcription factors are major actors regulating plant development and adaptability. Brassica napus is a staple oil crop and is hampered by lodging and diseases. Here, four B. napus MYB69 (BnMYB69s) genes were cloned and functionally characterized. They were dominantly expressed in stems during lignification. BnMYB69 RNA interference (BnMYB69i) plants showed considerable changes in morphology, anatomy, metabolism and gene expression. Stem diameter, leaves, roots and total biomass were distinctly larger, but plant height was significantly reduced. Contents of lignin, cellulose and protopectin in stems were significantly reduced, accompanied with decrease in bending resistance and Sclerotinia sclerotiorum resistance. Anatomical detection observed perturbation in vascular and fiber differentiation in stems, but promotion in parenchyma growth, accompanied with changes in cell size and cell number. In shoots, contents of IAA, shikimates and proanthocyanidin were reduced, while contents of ABA, BL and leaf chlorophyll were increased. qRT-PCR revealed changes in multiple pathways of primary and secondary metabolisms. IAA treatment could recover many phenotypes and metabolisms of BnMYB69i plants. However, roots showed trends opposite to shoots in most cases, and BnMYB69i phenotypes were light-sensitive. Conclusively, BnMYB69s might be light-regulated positive regulators of shikimates-related metabolisms, and exert profound influences on various internal and external plant traits

Nonlinear modeling and transition corridor calculation of a tiltrotor without cyclic pitch

In order to solve the problem of rotor airflow interference to the wing of tiltrotor UAV, the lift and drag in the slipstream area and the free flow area were calculated respectively according to the hydrodynamics theory and CFD simulation. The longitudinal nonlinear dynamics model of tiltrotor UAV is established by Newton-Euler method. In order to solve the problem that the lift and thrust are difficult to balance the body gravity in the transition flight mode, a method for calculating the transition corridor of a tiltrotor UAV without cyclic pitch is proposed. The boundary of the transition corridor is restricted by the Angle of attack of the wing and the thrust of the rotor. Considering the requirements of UAV cruise speed, flight safety and minimum energy consumption, the optimal transition curve is selected. The result show that the designed transition curve can ensure that the lift and the rotor thrust can balance the gravity completely and the Angle of attack is in a reasonable range, and the rotor force has enough margin of safety

Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma

Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K+ efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K+ efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications

Do Honored Cities Achieve a Sustainable Development? A Quasi-Natural Experimental Study Based on “National Civilized City” Campaign in China

As a new model of urban governance with Chinese characteristics, the national honored cities from city evaluation competitions, represented by the “National Civilized City” campaign, has always been popular among Chinese cities. Can the honored cities of the campaigns achieve sustainable development, and how? Based on the five concepts of sustainable development, which are innovation, coordination, green, openness and sharing, this study sets up a comprehensive index to measure the sustainability of the growth of a city. Then, the data of 242 Chinese cities from 2011 to 2019 and the difference-in-differences (DID) approach are used to evaluate the impacts of the Civilized City honored in the campaigns on the sustainability of growth. The results show that: (1) the “Civilized City” honor promotes sustainable development in Chinese cities; (2) the mechanism analysis shows that the “Civilized City” honor contributes to the sustainability of growth by effectively promoting the level of industrial agglomeration in cities; (3) further heterogeneity analysis shows that the effect of the “Civilized City” honor on the sustainability of growth varies by city size, the administrative level and the location of the city. By providing the evidence of economic effects of the “Civilized City” honor, this research rationalizes the city campaigns run by the Chinese government and provides important enlightenment for the continuous improvement of the selection mechanism of the national honored cities to promote sustainable development