Diastereoselective three-component synthesis of beta-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions

Diazo compounds, boranes, and acyl imines undergo a three-component Mannich condensation reaction under catalyst-free conditions to give the anti β-amino carbonyl compounds in high diastereoselectivity. The reaction tolerates a variety of functional groups, and an asymmetric variant was achieved using the (−)-phenylmenthol as chiral auxiliary in good yield and selectivity. These β-amino carbonyl compounds are valuable intermediates, which can be transformed to many potential bioactive molecules.We gratefully acknowledge Philip N. Moquist for editorial review of the manuscript. Preliminary experiments were performed by Y.L. at Boston University. Completion of the work was accomplished under the direction of G.W. at the University of Science and Technology Beijing, China. S.E.S. and Y.L. gratefully acknowledge the NIH for support (NIGMS R01 GM078240). Y.L., J.Y., and G.W. thank the Innovative Foundation from China National Petroleum Corporation (Grant No. 2012D-5006-0504) for financial support. Y.L. also thanks the Beijing Natural Science Foundation (Grant No. 2144052) and China Postdoctoral Science Foundation (2013M540859) for financial support. (NIGMS R01 GM078240 - NIH; 2012D-5006-0504 - Innovative Foundation from China National Petroleum Corporation; 2144052 - Beijing Natural Science Foundation; 2013M540859 - China Postdoctoral Science Foundation)Published versio

Spatio-temporal mapping of variation potentials in leaves of Helianthus annuus L. seedlings in situ using multi-electrode array.

Damaging thermal stimuli trigger long-lasting variation potentials (VPs) in higher plants. Owing to limitations in conventional plant electrophysiological recording techniques, recorded signals are composed of signals originating from all of the cells that are connected to an electrode. This limitation does not enable detailed spatio-temporal distributions of transmission and electrical activities in plants to be visualised. Multi-electrode array (MEA) enables the recording and imaging of dynamic spatio-temporal electrical activities in higher plants. Here, we used an 8 × 8 MEA with a polar distance of 450 μm to measure electrical activities from numerous cells simultaneously. The mapping of the data that were recorded from the MEA revealed the transfer mode of the thermally induced VPs in the leaves of Helianthus annuus L. seedlings in situ. These results suggest that MEA can enable recordings with high spatio-temporal resolution that facilitate the determination of the bioelectrical response mode of higher plants under stress

Examining Scientific Writing Styles from the Perspective of Linguistic Complexity

Publishing articles in high-impact English journals is difficult for scholars around the world, especially for non-native English-speaking scholars (NNESs), most of whom struggle with proficiency in English. In order to uncover the differences in English scientific writing between native English-speaking scholars (NESs) and NNESs, we collected a large-scale data set containing more than 150,000 full-text articles published in PLoS between 2006 and 2015. We divided these articles into three groups according to the ethnic backgrounds of the first and corresponding authors, obtained by Ethnea, and examined the scientific writing styles in English from a two-fold perspective of linguistic complexity: (1) syntactic complexity, including measurements of sentence length and sentence complexity; and (2) lexical complexity, including measurements of lexical diversity, lexical density, and lexical sophistication. The observations suggest marginal differences between groups in syntactical and lexical complexity.Comment: 6 figure

Realization of the unidirectional amplification in a cavity magnonic system

We experimentally demonstrate the nonreciprocal microwave amplification using a cavity magnonic system, consisting of a passive cavity (i.e., the split-ring resonator), an active feedback circuit integrated with an amplifier, and a ferromagnetic spin ensemble (i.e., a yttrium-iron-garnet sphere). Combining the amplification provided by the active circuit and the nonreciprocity supported by the cavity magnonics, we implement a nonreciprocal amplifier with the functions of both unidirectional amplification and reverse isolation. The microwave signal is amplified by 11.5 dB in the forward propagating direction and attenuated in the reverse direction by -34.7 dB, giving an isolation ratio of 46.2 dB. Such a unidirectional amplifier can be readily employed in quantum technologies, where the device can simultaneously amplify the weak signal output by the quantum system and isolate the sensitive quantum system from the backscattered external noise. Also, it is promising to explore more functions and applications using a cavity magnonic system with real gain.Comment: 7 pages, 4 figure

Research on the Application of Blockchain in SMEs Credit Risk

The credit of an enterprise is related to its own development. This paper mainly discusses the relationship between the credit risk of small and medium enterprises (SMEs) and the application degree of blockchain. 64 listed companies with block chain technology as the core theme are selected to analyze their comprehensive financial data. Factor analysis is used to quantitatively evaluate the application degree of blockchain in SMEs, and then the Logistic model is used to evaluate the credit risk of SMEs. Finally, combining the application degree of blockchain in small and medium-sized enterprises and the credit risk assessment of these two groups of data. It confirms the conclusion that the higher the degree of blockchain application, the closer the supply chain finance relationship, and the better the credit status

Two-mode correlated multiphoton bundle emission

The preparation of correlated multiphoton sources is an important research topic in quantum optics and quantum information science. Here, we study two-mode correlated multiphoton bundle emission in a nondegenerate multiphoton Jaynes-Cummings model, which is comprised of a two-level system coupled with two cavity modes. The two-level system is driven by a near-resonant strong laser such that the Mollow regime dominates the physical processes in this system. Under certain resonance conditions, a perfect super-Rabi oscillation between the zero-photon state $|0\rangle_{a}|0\rangle_{b}$ and the ($n+m$)-photon state $|n\rangle_{a}|m\rangle_{b}$ of the two cavity modes can take place. Induced by the photon decay, the two-mode correlated multiphoton bundle emission occurs in this system. More importantly, the results show that there is an antibunching effect between the strongly-correlated photon bundles, so that the system behaves as an antibunched ($n+m$)-photon source. The work opens up a route towards achieving two-mode correlated multiphoton source device, which has potential applications in modern quantum technology.Comment: 16 pages, 6 figures, to appear in Advanced Quantum Technologie