Research on Dynamic Response of Anchored Jointed Rock Slope under Traffic Load

Based on the actual slope engineering, the dynamic response characteristics of the anchored joint slope in acceleration, velocity, and anchorage cable axial force under traffic load are numerically simulated. The results show that the cable axial force of the anchored slope starts to rise from the anchor head under traffic load, reaches a stable value in the free section, and falls to close to zero in the anchorage section. The axial force of the anchorage cable decreases when the slope height increases. Within the free section of the anchorage cable, there is a "small platform", where the axial force value decreases slightly and rises again, and its position corresponds to the range in which the anchorage cable passes through the joint. The dynamic response of traffic loads to the monitoring points of the slope is related to the magnitude of the load, the frequency, and the duration of the vibration. It is also related to the distance from the location of the traffic load, the physical and mechanical parameters of the location, the existence of joints, cracks and other structural planes, and whether or not to take support measures. When the frequency of the traffic load is close to the natural frequency of the slope, the resonance phenomenon is easy to occur, and the damage of the rock and soil of the slope is increased

Best Practices of Liberal Arts Education: Curricula in Liberal Arts Colleges

As the primary example of best practice of liberal arts education, curricula in American liberal arts college have some distinctive features. Guided by the principle of integrating curriculum breadth and depth, both general education and major courses in liberal arts colleges may develop in a balanced way. Even the curriculum implementation at liberal arts colleges is fully reflective of the idea of liberal arts education. Small class sizes enhance students’ participation and promote intimate relations between faculty and students, and teachers’ investment in teaching occupies most of their time, which provides the conditions for high quality teaching. With the full cooperation of faculty, interdisciplinary curricula and majors are being developed continuously. All of these factors contribute to the nature of liberal arts education in liberal arts colleges’ curricula.This research is supported by The National Social Science Fund of China (Education) for young scholars (CIA160216)

METHOD OF PASSIVE PARTICIPANT TRACKING IN VIDEO CONFERENCE

An innovative technique is proposed to highlight video streams of participants mentioned by the current active speaker in a video conference. By immediately highlighting mentioned participants, valuable visual information can be delivered and perceived by meeting attendees so that meeting productivity is improved

CURSOR TRAIL IN ONLINE MEETING

Techniques are described to intelligently display a presenter’s cursor trail in an online meeting to enable all attendees in the meeting to easily recognize which part of shared content the presenter has recently discussed and/or is currently discussing. These techniques are completely automatic and therefore require no extra effort for the presenter or the attendees. The cursor trail is so tidy and intelligent that a convenient user experience is guaranteed. Productivity of collaboration in online meeting can thus be significantly improved

Research on Fatigue Damage and Affecting Factors of Defected Rock Mass Based on Ultrasonic Wave Velocity

In this paper the fatigue-loading test of defected rock-like specimen has been carried out by electro-hydraulic servo fatigue testing machine. At the same time, the ultrasonic data has been collected and analyzed by the digital ultrasonic instrument. The fatigue damage and influencing factors of the defective rock mass under dynamic load are studied. According to the experimental research and analysis, this paper chooses to define the damage variable by ultrasonic velocity, and the inverse function of the Logistic equation was used to describe the evolution curve of fatigue damage sample. The experimental data fitting results show that the damage model and the experimental data fit well. In addition, this paper analyzes the main influencing factors of fatigue damage in the test. The initial damage represents the damage state before the sample is cyclically loaded. Different initial damages have a significant effect on the fatigue life of the sample. In the case the initial damage is substantially the same, the upper limit stress is larger, the fatigue life of the sample is shorter, and conversely, the fatigue life is longer

Characterisation and internalisation of recombinant humanised HMFG-1 antibodies against MUC1

The humanised HMFG-1 immunoglobulin has been extensively developed as a clinical immunotherapeutic agent for MUC1 expressing tumours. We have constructed a single-chain Fv (scFv) and Fab fragment from this antibody and shown that both these species retain their specificity for MUC1. The scFv was less stable and less soluble than the Fab. Detailed analyses of the binding kinetics of the whole IgG and Fab fragment show that the affinity for MUC1 synthetic peptides is low (approximately 100 n for the IgG and 10 μ for the Fab), with particularly low but similar dissociation rate constants (0.031–0.095 s−1). Binding to native antigen on the cell surface is over two orders of magnitude better. Confocal immunofluorescence microscopy shows that both the IgG and Fab are internalised rapidly (the IgG is internalised within 15 min) and colocalise to early endosomes. This work provides an appreciation of the binding, internalising and trafficking kinetics, important for the development of future therapeutics based on this antibody

The Effect of Urban-Suburban Interaction on Urbanization and Suburban Ecological Security: A Case Study of Suburban Wuhan, Central China

In developing countries like China, urbanization is still occurring at a rapid pace. During urbanization, the urban land expands drastically, which makes suburbs the most affected area facing urban expansion. The land transition has proven to threaten the function and security of ecosystems, and therefore the topics of suburban land transition and ecological security have raised much attention. However, the urban-suburban interaction, which is one of the basic characteristics of suburbs, has been insufficiently considered. The urban-suburban interaction is developed based on the flows of people, materials, and information between urban and suburban areas, and it essentially reveals the relationship between human activities and land-use optimization. To fill the research gap, this study adopts a case study of Wuhan city, and first quantifies the urban-suburban interactions from a symbiotic perspective, and investigates rural residents and public buses to verify the estimated interactions. The results show that there is obvious heterogeneity in urban-suburban interactions in different suburban towns. Correlation analysis and geographic weight regression are then applied to demonstrate the relationship between the urban-suburban interaction and urbanization in the suburbs. Additionally, urbanization potential in the suburbs is estimated. Then, a suburban ecological security assessment is conducted by a “pressure-status-response” (PSR) model, and the urbanization potential that is estimated based on urban-suburban interaction is integrated as a “pressure” indicator. The comparison between the suburban ecological security assessment results based on considering and not considering urban-suburban interaction demonstrates the importance of considering urban-suburban interaction. This study contributes to the understanding of the complicated relationships of urban-suburban socio-economic, spatial, and ecological environments, and offers suggestions for suburban planning and ecological protection