Quality of User-Reported Data in Health Virtual Community

User-reported data are used in medical research and to support healthcare operations. However, the quality of user-reported data presents a major challenge. This paper is interested in investigating the data quality issues in HVC and possible causes and improvement

Posttraumatic stress on Chinese adolescents’ posttraumatic growth: The role of trauma centrality and emotion regulation

The current 6-month follow-up study investigated 1) the relationship between posttraumatic stress disorder (PTSD) at baseline (T1), trauma centrality and two types of cognitive emotion regulation (CER) at 3-month follow-up (T2), and psychiatric co-morbidity and posttraumatic growth (PTG) at 6-month follow-up (T3), 2) whether trauma centrality at T2 would mediate the impact of initial PTSD on psychiatric co-morbidity and PTG at T3, and 3) whether the two types of CER at T2 (i.e., adaptive CER and maladaptive CER) would respectively mediate the effect of initial PTSD on psychiatric co-morbidity and PTG at T3. Seven hundred and fifty-seven traumatized Chinese adolescents (Male = 400, Female = 357) from two secondary schools participated in the study and completed a demographic page, the Posttraumatic Stress Disorder Checklist for DSM-5, the Centrality of Events Scale, the Posttraumatic Growth Inventory, the General Health Questionnaire-28, the Cognitive Emotion Regulation Questionnaire, and the Educational Stress Scale for Adolescents. After controlling for demographic variables and academic stress, PTSD at baseline was positively associated with trauma centrality at T2, two types of CER at T2, and PTG at T3, but negatively related to psychiatric co-morbidity at T3. Trauma centrality at T2 did not mediate the impact of initial PTSD on psychiatric co-morbidity and PTG at T3. Both types of cognitive emotion regulation at T2 (i.e., adaptive CER and maladaptive CER) respectively mediated the effect of initial PTSD on PTG at T3 and but not that on psychiatric co-morbidity at T3. Following past trauma, Chinese adolescents might experience psychological distress as well as positive changes over time. These traumatic outcomes could be affected by adolescents’ thinking patterns about trauma, as opposed to by their concept of self. Adaptive thinking patterns promoted the positive effect of trauma onto personal growth, whereas the maladaptive patterns impaired the development of growth

Dual-view Curricular Optimal Transport for Cross-lingual Cross-modal Retrieval

Current research on cross-modal retrieval is mostly English-oriented, as the availability of a large number of English-oriented human-labeled vision-language corpora. In order to break the limit of non-English labeled data, cross-lingual cross-modal retrieval (CCR) has attracted increasing attention. Most CCR methods construct pseudo-parallel vision-language corpora via Machine Translation (MT) to achieve cross-lingual transfer. However, the translated sentences from MT are generally imperfect in describing the corresponding visual contents. Improperly assuming the pseudo-parallel data are correctly correlated will make the networks overfit to the noisy correspondence. Therefore, we propose Dual-view Curricular Optimal Transport (DCOT) to learn with noisy correspondence in CCR. In particular, we quantify the confidence of the sample pair correlation with optimal transport theory from both the cross-lingual and cross-modal views, and design dual-view curriculum learning to dynamically model the transportation costs according to the learning stage of the two views. Extensive experiments are conducted on two multilingual image-text datasets and one video-text dataset, and the results demonstrate the effectiveness and robustness of the proposed method. Besides, our proposed method also shows a good expansibility to cross-lingual image-text baselines and a decent generalization on out-of-domain data

Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction

BACKGROUND: Studies have demonstrated that carbonic anhydrase I (CA1) stimulates calcium salt precipitation and cell calcification, which is an essential step in new bone formation. Our study had reported that CA1 encoding gene has a strong association with rheumatoid arthritis (RA) and ankylosing spondylitis (AS), two rheumatic diseases with abnormal new bone formation and bone resorption in joints. This study investigated the effect of CA1 on joint inflammation and tissue destruction in transgenic mice that over-express CA1 (CA1-Tg). METHODS: CA1-Tg was generated with C57BL/6J mice by conventional methods. CA1-Tg was treated with collagen-II to induce arthritis (CIA). Wild-type mice, CA1-Tg treated with bovine serum albumin (BSA) and transgenic mice over-expressing PADI4 (PADI4-Tg), a gene known to be involved in rheumatoid arthritis, were used as controls. Histochemistry and X-ray radiographic assay were used to examine joint destruction. Western blotting and real time-PCR were used to examine CA1 expression. RESULTS: CIA was observed in 60% of CA1-Tg, 20% of PADI4-Tg and 20% of wild-type mice after collagen injections. No CIA was found in CA1-Tg mice that received injections of BSA. The arthritic score was 5.5 ± 0.84 in the CA1-Tgs but the score was less than 2 in the injected wild-type mice and the PADI4-Tgs. The thickness of the hind paws in the CA1-Tgs was 3.46 ± 0.11 mm, which was thicker than that of PADI4-Tgs (2.23 ± 0.08 mm), wild-type mice (2.08 ± 0.06 mm) and BSA-treated CA1-Tgs (2.04 ± 0.07 mm). Histochemistry showed obvious inflammation, synovial hyperplasia and bone destruction in the joints of CA1-Tg that was not detected in PADI4-Tgs or wild-type mice. X-ray assays showed bone fusion in the paws and spines of CA1-Tg mice. CONCLUSION: Over-expression of CA1 may aggravate joint inflammation and tissue destruction in the transgenic mice

Comparison between emerging adults and adults in terms of contamination fear, post-COVID-19 PTSD and psychiatric comorbidity

The present study compared Chinese emerging adults and adults regarding the association between contamination fear, posttraumatic stress disorder post-COVID-19 and psychiatric comorbidity after controlling for demographic and trauma exposure variables. 1089 Chinese civilians (M = 382; F = 707) with a mean age of 26 years (M = 26.36, SD = 8.58) were recruited from different provinces in China via an online survey posted on mainstream Chinese social networking platforms. They completed a demographic page with questions on trauma exposure, the Vancouver Obsessional Compulsive Inventory, the Posttraumatic Stress Disorder Checklist for DSM-5 and the General Health Questionnaire-28. Results showed that 12.7%, 68.7% and 18.6% met criteria for full, partial and no PTSD, respectively. Emerging adults reported significantly lower levels of symptoms of re-experiencing, avoidance, somatic problems, anxiety and fear of contamination than adults. In both emerging adults and adults, contamination fear was correlated with PTSD and psychiatric comorbidity. High educational attainment was significantly correlated with psychiatric comorbidity in emerging adults, but with PTSD in adults. Length of quarantine was correlated with psychiatric comorbidity only in adults. In conclusion, both emerging adults and adults developed varying levels of contamination fear, posttraumatic stress and general psychological symptoms following the outbreak of COVID-19. Emerging adults were more resilient than adults in coping with distress

Realizing 18.03% efficiency and good junction characteristics in organic solar cells via hydrogen-bonding interaction between glucose and ZnO electron transport layers

Electron transport layers (ETLs) with excellent electron extraction capability are essential for realizing high efficiency in organic solar cells (OSCs). A sol-gel-processed ZnO ETL is widely used in OSCs due to its high mobility and suitable work function. However, the existence of defects usually results in low photovoltaic performance during the operation of OSCs. In this work, glucose (Gl) was used to passivate free OH traps via hydrogen-bonding interaction and formed ZnO/Gl ETLs with ZnO, which exhibited improved electron extraction capability and reduced trap defect density. Thus, a champion efficiency of 18.03% was obtained in a PM6:Y6 light absorber-based cell, which is >11% higher than that of the reference cell (16.15%) with a pristine ZnO ETL. Impressive enhancements by >11% were also observed in different fullerene and non-fullerene light absorber-based cells relative to that of the reference cell. This study demonstrates a new strategy to design ETLs for realizing high efficiency in OSCs

Progress of All-inorganic Cesium Lead-free Perovskite Solar Cells

Metal halide-based perovskite solar cells (PSCs) have developed rapidly due to exceptional optoelectronic properties of perovskite materials (such as high optical absorption coefficient, long charge carrier lifetime, long diffusion length, high carrier mobility and tunable bandgaps) and low-cost fabrication processes. The record power conversion efficiency has exceeded 24%, demonstrating the great potential for photovoltaic application. However, the lead toxicity and instability still present as major obstacles for commercialization. In principle, Pb can be replaced with other less-toxic as well as environmentally benign metals, such as Ag, Na, Sn, Ge, Bi, Sb and Ti, to solve the toxicity issue. Replacing methylammonium (MA(+)) or formamidinium (FA(+)) with cesium (Cs+) represents a promising direction to address the instability issue. Herein, we review the recent progress of all-inorganic cesium lead-free halide PSCs. At the end, we outline challenges and future directions