A Survey on the Status of Smart Healthcare from the Universal Village Perspective

This survey paper discusses the condition of smart healthcare implementation. It discusses the current healthcare problems and how smart healthcare technologies ease the problems. Our group, Universal Village, realizes that the integration and interaction between parties in a system will maximize the effectiveness and benefit for the system. Based on this idea, this paper considers the smart city system as a whole, and talks about how smart healthcare interacts with infrastructures and functions inside and outside of the smart healthcare field. Then, it analyzes how a more powerful integrated system can be built from the smart healthcare system. In the end, several case studies are listed. Based on our analysis and the case studies, this paper then ended with the future prospects of the smart healthcare.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Guided Wave Propagation for Monitoring the Rail Base

In order to monitor the rail base, the dispersion characteristics and propagation properties of the guided wave are studied. Firstly, two modes named as Modes V1 and V2 are selected by the semianalytical finite element method (SAFE). The region at the bottom edge can be monitored by Mode V1, while the junction of the base edge and the flange can be detected by Mode V2. Then, the characteristics in the propagation process are analyzed using the finite element method (FEM). The two modes can be separated about 0.6 ms after they are excited. Thirdly, a wave attenuation algorithm based on mean is proposed to quantify the wave attenuation. Both waves can have weak attenuation and be detected within 5 m. Finally, a mode-identified experiment is performed to validate the aforementioned analysis. And a defect detection experiment is performed to demonstrate the excellent monitoring characteristics using Mode V2. These results can be used to monitor the rail base in practice engineering

Optimization of ultrasound-assisted extraction by response surface methodology, antioxidant capacity, and tyrosinase inhibitory activity of anthocyanins from red rice bran

The anthocyanins contents from red rice bran were characterized by HPLC/MS. Response surface methodology was used to optimize the ultrasound-assisted extraction of red rice bran anthocyanin. The antioxidant activities were evaluated in terms of IC50. The tyrosinase inhibitory activities of the anthocyanin samples from red rice bran and the standard substances were determined by a spectrophotometric method. According to mass spectrometry information, the main component of anthocyanins is paeoniflorin (m/z = 480). The optimized anthocyanin level was 5.80 mg/g under the following conditions: solid–liquid ratio of 1:17.46; ethanol concentration of 78.37%; ultrasonication time of 55.23 min; and pH of 2.31. The IC50 value of the DPPH radical scavenging and the superoxide anion scavenging activities of the sample were 53.51 and 2,375 μg/ml; those of the standard were 14.60 and 64.74 μg/ml; and those of vitamin C were 24.45 and 136.25 μg/ml, respectively. The IC50 values of the tyrosinase inhibition activities of the sample and Vc were 4.26 and 2.18 μg/ml, respectively. There is a significant difference (p < .05) between the activities of the three, which may be caused by the purity of the extract. Red rice bran anthocyanins have valuable research and development prospects as skin whiteners and healthcare products

Reducing the damage of quinoa saponins on human gastric mucosal cells by a heating process

Different food processing methods will influence the structure and activity of compounds. In this work, molecular structure and different content crude saponins that were extracted from quinoa, treated with water soaking, water boiling, and water steaming were analyzed by HPLC. Flow cytometry was employed to investigate the effects of the main saponins on the GES-1 cell line. HPLC/MS analysis revealed that water soaking induced an extensive conversion of polar saponin Qc (424.41 ± 21.11 mg/g) to the less polar compound Qf (247.04 ± 15.71 mg/g). After treatment with 100 μg of Qf instead of Qc for 24 hr, the percentage of dead cells increased from 20.1 ± 2.2% to 86.2 ± 4.8%. One major reason of this result is that less polar saponins could damage membrane integrity more easier than polar saponins. The results indicate that saponin toxicity is enhanced after degradation, so it is necessary to avoid degradation before use

Genetic characterization of maize germplasm derived from Suwan population and temperate resources

Abstract Background The Suwan population is a well-known maize germplasm that has greatly contributed to the development of maize breeding in tropical and subtropical regions, especially in southern China. Inbred lines derived from the Suwan population always contain stronger resistance and extensive adaptability in different environments. To evaluate the genetic character of inbred lines derived from the Suwan population, a panel including 226 inbred line derived from the Suwan population and temperate resources was assembled and genotyped by using MaizeSNP50 BeadChip, which contained 56,110 genome-wide single nucleotide polymorphism (SNP) markers. This panel contained 98 temperate inbred line and 128 lines derived from the Suwan population. Results The results showed that high genetic diversity was found, with PIC and GD to be 0.67 and 0.60, respectively. In addition, two novel subgroups were identified, with representative inbred lines as HCL645 and Ki32, respectively. One acknowledged heterotic group of Iowa Stiff Stalk Synthetic (SS) was also identified in this study. This study can provide some additional scientific evidence for heterotic group division and use in maize. Additionally, lower linkage disequilibrium (LD) levels and weaker genetic relationships were found, with an average LD level of 41.15 kb that varied from 3.5 to 96 kb. A total of 82.8% of paired relative kinships ranged from 0.05 to 0.28. Conclusions These results would not only facilitate maize breeding practices in tropical and subtropical regions, but also revealed that this panel can be used in dissecting the genetic basis of complex quantitative traits’ variations by using genome-wide association studies (GWAS)

Extending the Host Range of Fusarium Poae Virus 1 from Fusarium poae to other Fusarium Species in the Field

Fusarium poae virus 1 (FpV1, a betapartitivirus) is one of the mycoviruses which is discovered earlier. Due to the vegetative incompatibility barrier that often exists between different species or strains of filamentous fungi, FpV1 has been thought to be limited to its host, F. poae, as a non-hypovirulence mycovirus in the past 20 years in the field. Here, a novel strain of FpV1 (FpV1-Fa) with two dsRNA segments (2157-and 2080-nt) was consistently identified in F. asiaticum isolates in the field. FpV1-Fa induced abnormal morphology and hypovirulence of F. asiaticum, along with a high viral load. FpV1-Fa was detected only from the F. asiaticum and F. tricinctum strains at a FpV1-Fa sampling site (119.014289, 33.8261), while the other strains from other sites were not identified FpV1-Fa. A horizontal transmission experiment showed that FpV1-Fa can transfer from F. asiaticum to F. poae and F. tricinctum, but not to F. graminearum. The selection analysis of FpV1-Fa revealed RdRP and CP were under strong purifying selection, and the C-terminal side of RdRP was under positive selection. In these regions, 9 amino acid mutations in RdRP and 21 mutations in CP appeared to cause the variation of host range and virulence in FpV1-Fa

Evaluation of Antibacterial and Anti-inflammatory Activities of Less Polar Ginsenosides Produced from Polar Ginsenosides by Heat-transformation

Ginsenosides are the major active constituents in both white and red American ginseng (AG), and their pharmacological effects on central nervous, cardiovascular, and endocrine systems have been well elucidated. However, the anti-<i>Propionibacterium acnes</i> (<i>P. acnes</i>) activity of them is still unknown. In this study, 5 ginsenosides enriched fractions were obtained from the total ginsenosides extract of AG roots (TAG) by resin adsorption and heat-transformation. Resin purification decreased the total polyphenol (TP) content in the fractions. However, heat treatment increased the TP content and induced extensive conversion of the polar ginsenosides (Rg₁, Re, Rb₁, Rc, Rb₂, Rd, and Gyp XVII) to less polar compounds (Rg₂, Rg₃, Rg₆/F₄, Rs₃, and Rg₅/Rk₁). Only the heat-treated fraction from 65% methanol elution of the HP-20 column (HPHF) showed antibacterial activity against <i>P. acnes</i> (ATCC11827, MIC, 128 μg/mL; ATCC6919 MIC, 64 μg/mL), <i>S. epidermidis</i> (MIC, 4100 μg/mL) and <i>S. aureus</i> (MIC, 15000 μg/mL). In the anti-inflammatory activity assay, 10 μg/mL of HPHF significantly (<i>P</i> < 0.05) inhibited NO production in LPS-stimulated RAW264.7 cells. These results suggest that less polar ginsenosides enriched fraction HPHF obtained from AG might be useful to develop new types of antibacterial substances and new skin care cosmetics for acne prevention and therapy

Supplemental material for Obstructive sleep apnea and risk of aortic dissection: A meta-analysis of observational studies

<p>Supplemental material for Obstructive sleep apnea and risk of aortic dissection: A meta-analysis of observational studies by Xiushi Zhou, Fei Liu, Wei Zhang, Guili Wang, Daqiao Guo, Weiguo Fu and Lixin Wang in Vascular</p