328 research outputs found
An Impulsive Three-Species Model with Square Root Functional Response and Mutual Interference of Predator
An impulsive two-prey and one-predator model with square root functional responses, mutual interference, and integrated pest management is constructed. By using techniques of impulsive perturbations, comparison theorem, and Floquet theory, the existence and global asymptotic stability of prey-eradication periodic solution are investigated. We use some methods and sufficient conditions to prove the permanence of the system which involve multiple Lyapunov functions and differential comparison theorem. Numerical simulations are given to portray the complex behaviors of this system. Finally, we analyze the biological meanings of these results and give some suggestions for feasible control strategies
GCNs-Net: A Graph Convolutional Neural Network Approach for Decoding Time-resolved EEG Motor Imagery Signals
Towards developing effective and efficient brain-computer interface (BCI)
systems, precise decoding of brain activity measured by electroencephalogram
(EEG), is highly demanded. Traditional works classify EEG signals without
considering the topological relationship among electrodes. However,
neuroscience research has increasingly emphasized network patterns of brain
dynamics. Thus, the Euclidean structure of electrodes might not adequately
reflect the interaction between signals. To fill the gap, a novel deep learning
framework based on the graph convolutional neural networks (GCNs) was presented
to enhance the decoding performance of raw EEG signals during different types
of motor imagery (MI) tasks while cooperating with the functional topological
relationship of electrodes. Based on the absolute Pearson's matrix of overall
signals, the graph Laplacian of EEG electrodes was built up. The GCNs-Net
constructed by graph convolutional layers learns the generalized features. The
followed pooling layers reduce dimensionality, and the fully-connected softmax
layer derives the final prediction. The introduced approach has been shown to
converge for both personalized and group-wise predictions. It has achieved the
highest averaged accuracy, 93.056% and 88.57% (PhysioNet Dataset), 96.24% and
80.89% (High Gamma Dataset), at the subject and group level, respectively,
compared with existing studies, which suggests adaptability and robustness to
individual variability. Moreover, the performance was stably reproducible among
repetitive experiments for cross-validation. To conclude, the GCNs-Net filters
EEG signals based on the functional topological relationship, which manages to
decode relevant features for brain motor imagery
The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization.
The G-protein-coupled estrogen receptor 1 (GPER) has recently been reported to mediate the non-genomic action of estrogen in different types of cells and tissues. G-1 (1-[4-(6-bromobenzo[1,3] dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone) was developed as a potent and selective agonist for GPER. G-1 has been shown to induce the expression of genes and activate pathways that facilitate cancer cell proliferation by activating GPER. Here we demonstrate that G-1 has an anticancer potential with a mechanism similar to vinca alkaloids, the commonly used chemotherapy drugs. We found that G-1 blocks tubulin polymerization and thereby interrupts microtubule assembly in ovarian cancer cells leading to the arrest of cell cycle in the prophase of mitosis and the suppression of ovarian cancer cell proliferation. G-1 treatment also induces apoptosis of ovarian cancer cells. The ability of G-1 to target microtubules to suppress ovarian cancer cell proliferation makes it a promising candidate drug for treatment of ovarian cancer
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