13 research outputs found
Training A Multi-stage Deep Classifier with Feedback Signals
Multi-Stage Classifier (MSC) - several classifiers working sequentially in an
arranged order and classification decision is partially made at each step - is
widely used in industrial applications for various resource limitation reasons.
The classifiers of a multi-stage process are usually Neural Network (NN) models
trained independently or in their inference order without considering the
signals from the latter stages. Aimed at two-stage binary classification
process, the most common type of MSC, we propose a novel training framework,
named Feedback Training. The classifiers are trained in an order reverse to
their actual working order, and the classifier at the later stage is used to
guide the training of initial-stage classifier via a sample weighting method.
We experimentally show the efficacy of our proposed approach, and its great
superiority under the scenario of few-shot training
AG-CRC: Anatomy-Guided Colorectal Cancer Segmentation in CT with Imperfect Anatomical Knowledge
When delineating lesions from medical images, a human expert can always keep
in mind the anatomical structure behind the voxels. However, although
high-quality (though not perfect) anatomical information can be retrieved from
computed tomography (CT) scans with modern deep learning algorithms, it is
still an open problem how these automatically generated organ masks can assist
in addressing challenging lesion segmentation tasks, such as the segmentation
of colorectal cancer (CRC). In this paper, we develop a novel Anatomy-Guided
segmentation framework to exploit the auto-generated organ masks to aid CRC
segmentation from CT, namely AG-CRC. First, we obtain multi-organ segmentation
(MOS) masks with existing MOS models (e.g., TotalSegmentor) and further derive
a more robust organ of interest (OOI) mask that may cover most of the
colon-rectum and CRC voxels. Then, we propose an anatomy-guided training patch
sampling strategy by optimizing a heuristic gain function that considers both
the proximity of important regions (e.g., the tumor or organs of interest) and
sample diversity. Third, we design a novel self-supervised learning scheme
inspired by the topology of tubular organs like the colon to boost the model
performance further. Finally, we employ a masked loss scheme to guide the model
to focus solely on the essential learning region. We extensively evaluate the
proposed method on two CRC segmentation datasets, where substantial performance
improvement (5% to 9% in Dice) is achieved over current state-of-the-art
medical image segmentation models, and the ablation studies further evidence
the efficacy of every proposed component.Comment: under revie
The relationship between future self-continuity and intention to use Internet wealth management: The mediating role of tolerance of uncertainty and trait anxiety
This study aimed to analyze the mediating effect of tolerance of uncertainty (TU) and trait anxiety (TA) on future self-continuity (FSC) and intention to use Internet wealth management (IUIWM) systems. A questionnaire survey was distributed online and a total of 388 participants completed questionnaire, The questionnaire included the following scales: Chinese version of the FSC, Intention to Use the Internet Wealth Management, TU, and TA. Pearson correlation was used to investigate the correlation coefficient between variables while the sequential regression method was used to analyze relationship between variables. To analyze the collected data, the SPSS 26.0 was used. A two-step procedure was applied to analyze the mediation effect. Confirmatory factor analysis (CFA) was conducted to test the measurement model. Afterward, the Maximum Likelihood method was used for path analysis, and the Bias-corrected Bootstrap method was used to investigate determine the estimated value and confidence interval of the mediating effect
Microbial proteases and their applications
Proteases (proteinases or peptidases) are a class of hydrolases that cleave peptide chains in proteins. Endopeptidases are a type of protease that hydrolyze the internal peptide bonds of proteins, forming shorter peptides; exopeptidases hydrolyze the terminal peptide bonds from the C-terminal or N-terminal, forming free amino acids. Microbial proteases are a popular instrument in many industrial applications. In this review, the classification, detection, identification, and sources of microbial proteases are systematically introduced, as well as their applications in food, detergents, waste treatment, and biotechnology processes in the industry fields. In addition, recent studies on techniques used to express heterologous microbial proteases are summarized to describe the process of studying proteases. Finally, future developmental trends for microbial proteases are discussed