51 research outputs found

    SPSTracker: Sub-Peak Suppression of Response Map for Robust Object Tracking

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    Modern visual trackers usually construct online learning models under the assumption that the feature response has a Gaussian distribution with target-centered peak response. Nevertheless, such an assumption is implausible when there is progressive interference from other targets and/or background noise, which produce sub-peaks on the tracking response map and cause model drift. In this paper, we propose a rectified online learning approach for sub-peak response suppression and peak response enforcement and target at handling progressive interference in a systematic way. Our approach, referred to as SPSTracker, applies simple-yet-efficient Peak Response Pooling (PRP) to aggregate and align discriminative features, as well as leveraging a Boundary Response Truncation (BRT) to reduce the variance of feature response. By fusing with multi-scale features, SPSTracker aggregates the response distribution of multiple sub-peaks to a single maximum peak, which enforces the discriminative capability of features for robust object tracking. Experiments on the OTB, NFS and VOT2018 benchmarks demonstrate that SPSTrack outperforms the state-of-the-art real-time trackers with significant margins.Comment: Accepted as oral paper at AAAI202

    Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acutely decompensated cirrhosis

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    BACKGROUND AND AIMS: Although the effect of bacterial infection on cirrhosis has been well-described, the effect of non-hepatotropic virus (NHV) infection is unknown. This study evaluated the genome fragments of circulating microorganisms using metagenomic next-generation sequencing (mNGS) in cirrhosis patients with acute decompensation (AD), focusing on NHVs and related the findings to clinical outcomes. METHODS: Plasma mNGS was performed in 129 cirrhosis patients with AD in study cohort. Ten healthy volunteers and 20, 39, and 81 patients with stable cirrhosis, severe sepsis and hematological malignancies, respectively, were enrolled as controls. Validation assays for human cytomegalovirus (CMV) reactivation in a validation cohort (n = 58) were performed and exploratory treatment instituted. RESULTS: In study cohort, 188 microorganisms were detected in 74.4% (96/129) patients, including viruses (58.0%), bacteria (34.1%), fungi (7.4%) and chlamydia (0.5%). Patients with AD had an NHV signature, and CMV was the most frequent NHV, which correlated with the clinical effect of empirical antibiotic treatment, progression to acute-on-chronic liver failure (ACLF), and 90-day mortality. The NHV signature in ACLF patients was similar to patients with sepsis and hematological malignancies. The treatable NHV, CMV was detected in 24.1% (14/58) patients in the validation cohort. Of the 14 cases with detectable CMV by mNGS, 9 were further validated by DNA RT-PCR or pp65 antigenemia testing. Three patients with CMV reactivation received ganciclovir therapy in exploratory manner with clinical resolutions. CONCLUSIONS: The results of this study suggests that NHVs may have a pathogenic role in complicating the course of AD. Further validation is needed to define whether this should be incorporated in the routine management of AD patients. IMPACT AND IMPLICATIONS: ●Cirrhosis patients with acute decompensation have a non-hepatotropic virus (NHV) signature, which is similar to that in sepsis and hematological malignancies patients. ●The detected viral signature had clinical correlates, including clinical efficacy of empirical antibiotic treatment, progression to acute-on-chronic liver failure and short-term mortality. ●The treatable NHV, CMV reactivation may be involved in the clinical outcomes of decompensated cirrhosis. ●Routine screening for NHVs, especially CMV, may be useful for the management of patients with acutely decompensated cirrhosis

    Cost Optimization of Two-Dimensional Warranty Products under Preventive Maintenance

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    Aiming to reduce the warranty cost, we put forward a new warranty strategy of two-dimensional (2D) warranty products. In this strategy, the incomplete preventive maintenance and minimal repair are proposed where the preventive maintenance is further divided by the degree of maintenance, and all other failures are repaired minimally. Preventive maintenance of different degree is put forward by the manufacturer and the user, respectively, and the repair factor is used to distinguish the different degree of maintenance. We establish model of warranty cost based on reliability theory and propose a method to solve the model. Finally, the validity of this model is proved by a numerical example, and the sensitivity analysis is carried out

    Effective dust cleaning intensity of high temperature filter bag

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    In order to investigate the effective dust cleaning intensity of high temperature filter bag, the maximum peak pressures on the internal filter bag surface and pressure drops of the filter were tested on a size Φ120 mm×2 000 mm filter bag made of FuMeiSi(FMS) needle felt, and the wear of the filter bag was also observed in this study. The results show that the maximum peak pressure has a rational distribution values in which the filter bag has a good cleaning effect with less wear on filter bag. For fly ashes, the average value 876 Pa of maximum peak pressure along the height of the filter bag could meet the cleaning requirements of the filter. The bigger the maximum peak pressure was, the better the cleaning effect was. However, when the average value of filter bag's the maximum peak pulse pressure exceeded 2 713 Pa, the cleaning effect only increased slightly. Moreover, the filter bag would be worn out to cause excessive cleaning once the maximum peak pulse pressure exceeded 5 282 Pa in some part of the filter bag

    Effects of different debridement methods on titanium surfaces in vitro

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    Objective To investigate the effect of different decontamination methods, including photodynamic therapy, sandblasting and titanium curette, on titanium surface morphology and bacterial adhesion for the treatment of peri-implant disease. Methods Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were inoculated on the surface of polished titanium specimens, and titanium specimen surfaces were treated with different decontamination methods after incubation. The titanium specimens were divided into a no-treatment control group, photodynamic group, sandblasting group and titanium curette group according to different decontamination methods. The changes in titanium surface roughness were observed by atomic force microscopy (AFM), and the remaining bacteria on the titanium surface were observed by scanning electron microscopy (SEM) and live/dead bacteria staining tests. After reinoculation of Pg and Fn, bacterial readhesion was observed on the surface of decontaminated titanium specimens. Results The AFM results showed that the surface roughness of the titanium curette group was significantly higher than that of the no-treatment control group, photodynamic group and sandblasting group (P0.05). The results of contact angle measurement showed that the surface contact angle of each treatment group was smaller than that of the no-treatment control group (P<0.05). The SEM results obtained after the titanium specimen surface was decontaminated showed that the number of bacteria on the no-treatment control group surface was higher and the bacteria were relatively concentrated. The bacteria on the surface of the photodynamic group, sandblasting group and titanium curette group were scattered and distributed in small numbers, and most bacteria on the surface of the photodynamic group were ruptured. The results of the live/dead bacteria staining experiment showed that the percentage of dead bacteria on the surface of the photodynamic group was significantly higher than that of the no-treatment control group, sandblasting group and titanium curette group (P<0.05). The remaining bacteria on the surface of the sandblasting group and titanium curette groups were mainly live bacteria. The remaining bacterial adhesion on the surface was significantly reduced for the sandblasting group compared to the no-treatment control group and the photodynamic and titanium curette groups (P<0.05). SEM and live/dead bacteria staining results of bacterial readhesion on the surface of titanium specimens showed that there was an aggregation of Pg on the surface of the titanium curette group, and its surface bacterial adhesion was significantly higher than that of the no-treatment control group, photodynamic group and sandblasting group. Conclusion In mechanical decontamination, sandblasting machines are a better option than photodynamic therapy and titanium curettes; however, sandblasting does not remove all bacterial contamination. For sterilization, photodynamic therapy is more effective than sandblasting and titanium curettes. A combination of sandblasting and photodynamic therapy methods for the treatment of peri-implant disease may be considered in clinical practice

    Chitosan Hydrogel as siRNA vector for prolonged gene silencing

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