A theoretical study on the mechanism of the addition reaction between cyclopropenylidene and ethylene

The reaction mechanism between cyclopropenylidene and ethylene has been systematically investigated employing the MP2/6-311+G* level of theory to better understand the cyclopropenylidene reactivity with unsaturated hydrocarbons. Geometry optimization, vibrational analysis, and energy property for the involved stationary points on the potential energy surface have been calculated. Energies of all the species are also further refined by the CCSD(T)/6-311+G* single-point calculations. Firstly, one important reaction intermediate (INTa) has been located via a transition state (TSa). After that, the common intermediate (INTb) for the two pathways (1) and (2) has been formed via TSb. At last, two different products possessing three- and four-membered ring characters have been obtained through two reaction pathways. In the reaction pathway (1), a three-membered ring alkyne compound has been obtained. As for the reaction pathway (2), a four-membered ring conjugated diene compound has been formed, which is the most favorable reaction to occur from the kinetic and thermodynamic viewpoints

Harvest Video Foundation Models via Efficient Post-Pretraining

Building video-language foundation models is costly and difficult due to the redundant nature of video data and the lack of high-quality video-language datasets. In this paper, we propose an efficient framework to harvest video foundation models from image ones. Our method is intuitively simple by randomly dropping input video patches and masking out input text during the post-pretraining procedure. The patch dropping boosts the training efficiency significantly and text masking enforces the learning of cross-modal fusion. We conduct extensive experiments to validate the effectiveness of our method on a wide range of video-language downstream tasks including various zero-shot tasks, video question answering, and video-text retrieval. Despite its simplicity, our method achieves state-of-the-art performances, which are comparable to some heavily pretrained video foundation models. Our method is extremely efficient and can be trained in less than one day on 8 GPUs, requiring only WebVid-10M as pretraining data. We hope our method can serve as a simple yet strong counterpart for prevalent video foundation models, provide useful insights when building them, and make large pretrained models more accessible and sustainable. This is part of the InternVideo project \url{https://github.com/OpenGVLab/InternVideo}

MicroRNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of hCG administration

Background: To determine the effect of higher progesterone (P) level on endometrial receptivity. Methods: This was a prospective analysis conducted in the Reproductive Medical Center of Peking University Third Hospital. All patients received IVF treatment and canceled embryo transfer in the same cycle and were divided into group 1 (normal P; 7 patients) and group 2 (elevated P; 12 patients). Endometrial biopsies were performed 6 days after oocyte retrieval. The global miRNA and mRNA gene expressions in endometrial biopsies were investigated with a V4.0 miRNA probe and 22 K Human Genome Array. Fold ratios were derived to compare gene regulation between the groups. Spp1 and Ang gene expression was selected to verify the array results by RT-PCR and the protein expression of osteopontin and VEGF was determined using an immunohistochemical method. Results: There were 4 miRNA (all down-regulated) and 22 mRNA (13 up-regulated and 9 down-regulated) exhibiting differential expression between the groups on the microRNA and microarray chips. miRNA-451, Spp1, and Ang expression in RT-PCR verified the array results. Osteopontin and VEGF were also shown to have positive expression in the endometrium. Conclusions: Data from microRNA and microarray analysis suggests dissimilar endometrial receptivity in patients with high P levels on the day of hCG, and elevated osteopontin and decreased VEGF had poor pregnancy rates.Endocrinology & MetabolismReproductive BiologySCI(E)PubMed21ARTICLE29

The relationship between marital adjustment and personality characteristics, medical coping style of infertile patients

目的  探讨不孕不育患者婚姻调适状况与人格特征和医学应对方式的关系，为临床开展心理健康干预提供依据。方法  选取2012年8月—2015年1月某三级甲等医院生殖医学中心治疗的156例已婚不孕不育症患者。采用艾森克人格问卷表（EPQ）、Locke-Wollance婚姻调适测定量表和医学应对问卷（MCMQ），对患者进行调查，分别测评患者婚姻调适状况、人格特征和医学应对方式及其相关性。结果  患者婚姻调适状况与EPQ的P、N及MCMQ屈服呈显著负相关，与EPQ 的E和MCMQ面对则呈显著正相关；EPQ的P、N与MCMQ面对呈负相关，与MCMQ的屈服呈正相关；EPQ的E则与MCMQ面对呈显著正相关。EPQ的P、E、N和MCMQ面对、屈服在婚姻调适状况高中低分组中的比较，差异均有统计学意义（均P＜0.01）。多元逐步回归分析：面对、回避，屈服及精神质（P）等4个因素共解释了不孕不育症患者婚姻调适总变异的26.4%。结论  人格特征、医学应对方式是影响不孕不育症患者婚姻调适的重要因素。Objective: To explore the relationship between marital adjustment and personality characteristics and coping styles of patients with infertility, and to provide evidence for clinical intervention. Methods: A total of 156 patients with infertility were selected from August 2012 to January 2015 in a grade a hospital of reproductive medicine center. This research is a cross - sectional survey. The Eysenck Personality Questionnaire (EPQ), Locke-Wollance marital adjustment test scale and Medical Coping Questionnaire (MCMQ), were investigated, respectively, to evaluate the patient status, marital adjustment and personality characteristics and coping style and their relationship. Results: Patients marital adjustment status and EPQ P, N and MCMQ yield was significantly negative correlated, and EPQ E and MCMQ was significantly positively related; EPQ P, N and MCMQ showed a negative correlation, and MCMQ yield positively correlated; EPQ E, and MCMQ face was significantly positively related, EPQ P, E, N and MCMQ, yield in the marital adjustment the conditions of grouping, the differences were statistically significant (all P < 0.01). Multiple stepwise regression analysis: 4 factors, such as confrontation, avoidance, yield and psychoticism (P), were used to explain the total variation of the adjustment of marriage in infertile patients (26.4%). Conclusion: Personality characteristics, medical coping styles are the important factors influencing the marital adjustment for infertility patients

Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells

AbstractObjectiveTo evaluate of the curative effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on rat acute radiation pneumonitis.MethodsFourty rats were randomly divided into control group, radiation group, stem cell prevention group, stem cell treatment group and prednisone treatment group. All rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage model. The hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein (1×106 cells/kg BW) 24 h before the radiation, while the same administration was performed in the rats of the treatment group 24 h after the radiation. After 24 h post the radiation, the rats in the radiation group were given 0.4 mL physiological saline, and those in the prednisone group were given 1 mg/kg prednisone. All rats were observed and executed 72 h after the radiation to detect lung histological changes.ResultsAfter the administration of hUC-MSCs, the survival status of the rats in the prevention group and treatment group was obviously better than that in the control group. As shown by the histological staining, the morphology, proliferation activity and bronchial state of lung tissues were better in the prevention group and treatment group than in the control group.ConclusionsThe hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats

Impact of food safety supervision efficiency on preventing and controlling mass public crisis

Food safety has received unprecedented attention since the COVID-19 outbreak. Exploring food safety regulatory mechanisms in the context of cluster public crises is critical for COVID-19 prevention and control. As a result, using data from a food safety regulation survey in the Bei-jing-Tianjin-Hebei urban cluster, this paper investigates the impact of food safety regulation on the prevention and control of COVID-19. The study found that food safety regulation and cluster public crisis prevention and control have a significant positive relationship, with the ability to integrate regulatory resources acting as a mediator between the two. Second, industry groups argue that the relationship between regulatory efficiency and regulatory resource integration should be moderated in a positive manner. Finally, industry association support positively moderates the mediating role of regulatory re-source integration capacity between food safety regulatory efficiency and cluster public crises, and there is a mediating effect of being moderated. Our findings shed light on the mechanisms underlying the roles of regulatory efficiency, resource integration capacity, and industry association support in food safety, and they serve as a useful benchmark for further improving food safety regulations during the COVID-19 outbreak