Solving The Muon g-2 Anomaly With Natural NMSSM From Generalized Deflected AMSB

We propose to realize (natural) NMSSM spectrum from deflected AMSB with new messenger-matter interactions. With additional messenger-matter interactions involving ${\bf 10}\oplus{\bf \overline{10}}$ representation messengers, the muon g-2 anomaly can be solved at $2\sigma$ (or $3\sigma$) level with the corresponding gluino mass range $2.8~{\rm TeV}<m_{\tilde{g}}<5.4~ {\rm TeV}$ (or $2.6 ~{\rm TeV}<m_{\tilde{g}}<7.3~ {\rm TeV}$). Besides, our scenario is fairly natural within which the involved fine tuning can be as low as 47. So, in the framework of AMSB-type scenarios, NMSSM can be advantageous in explaining the muon g-2 anomaly in compare with MSSM.Comment: 23 pages, 7 figure

Trustworthy Edge Machine Learning: A Survey

The convergence of Edge Computing (EC) and Machine Learning (ML), known as Edge Machine Learning (EML), has become a highly regarded research area by utilizing distributed network resources to perform joint training and inference in a cooperative manner. However, EML faces various challenges due to resource constraints, heterogeneous network environments, and diverse service requirements of different applications, which together affect the trustworthiness of EML in the eyes of its stakeholders. This survey provides a comprehensive summary of definitions, attributes, frameworks, techniques, and solutions for trustworthy EML. Specifically, we first emphasize the importance of trustworthy EML within the context of Sixth-Generation (6G) networks. We then discuss the necessity of trustworthiness from the perspective of challenges encountered during deployment and real-world application scenarios. Subsequently, we provide a preliminary definition of trustworthy EML and explore its key attributes. Following this, we introduce fundamental frameworks and enabling technologies for trustworthy EML systems, and provide an in-depth literature review of the latest solutions to enhance trustworthiness of EML. Finally, we discuss corresponding research challenges and open issues.Comment: 27 pages, 7 figures, 10 table

Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15

Immunostain of CD68 in entire tissue of FTC/FA samples. (A) An example of immunohistochemistry analysis of CD68 in whole tissue samples of FTC (left panel) and FA (right panel). Stars indicated blank areas were taked out for tissue microarrays constructing. CD68+ cells in ten 200 μm *300 μm areas (green-red marked) of every sample were counted. Bar = 1 mm. (B) Enlarged picture of one count area (one green-red area in A). Arrows indicate the CD68+ macrophages in FTC (left panel) or FA (right panel). Bar = 20 μm. Figure S2. Densities of CD206+ cells in FTC are significantly higher than those in FA. Immunohistochemistry analysis of CD206 in 55 cases of tissue samples from FTC and FA patients. Arrows indicate the CD206+ macrophages. Bar = 20 μm. (PDF 509 kb

Numerical Research on The Nozzle Damping Effect by A Wave Attenuation Method

AbstractNozzle damping is one of the most important factors in the suppression of combustion instability in solid rocket motors. For an engineering solid rocket motor that experiences combustion instability at the end of burning, a wave attenuation method is proposed to assess the nozzle damping characteristics numerically. In this method, a periodic pressure oscillation signal which frequency equals to the first acoustic mode is superimposed on a steady flow at the head end of the chamber. When the pressure oscillation is turned off, the decay rate of the pressure can be used to determine the nozzle attenuation constant. The damping characteristics of three other nozzle geometries are numerically studied with this method under the same operating condition. The results show that the convex nozzle provides more damping than the conical nozzle which in turn provides more damping than the concave nozzle. All the three nozzles have better damping effect than that of basic nozzle geometry. At last, the phase difference in the chamber is analyzed, and the numerical pressure distribution satisfies well with theoretical distribution

Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography

ObjectivesOwing to its structural and anatomic characteristics, imaging of the lymphatic system has been difficult. The conventional diagnostic method of radionuclide-based imaging has the disadvantage of poor resolution. Recent work has shown that magnetic resonance imaging (MRI) can depict lymphatic channels in patients with lymphedema. This study evaluated the anatomic and functional images of contrast MR lymphangiography in the diagnosis of limb lymphatic circulation disorders.MethodsThe study enrolled 27 patients with primary lymphedema. Four patients had bilateral disease, and 23 had unilateral disease. Contrast-enhanced lymphangiography was performed with a 3.0-T MR unit after the intracutaneous injection of gadobenate dimeglumine into the interdigital webs of the dorsal foot. The kinetics of enhanced lymph flow within the lymphatic system were calculated using the formula [speed in cm = total length of visualized lymph vessel in cm/inspection time in minutes] and by comparing dynamic nodal enhancement and time-signal intensity curves between edematous and contralateral limbs. Morphologic abnormalities of the lymphatic system were also evaluated.ResultsExamination of the MRIs after injection of the contrast agent showed enhanced lymphatic channels consistently visualized in all clinical lymphedematous limbs and in five contralateral limbs of unilateral lymphedema patients. The speed of flow within the lymphatics of lymphedematous limbs was 0.3 to 1.48 cm/min. Contrast enhancement in inguinal nodes of edematous limbs was significantly less than that of contralateral limbs (P < .01). Dynamic measurement of contrast enhancement showed a remarkable lowering of peak time (P < .01) and peak enhancement (P < .01), and a delay in outflow in inguinal nodes of affected limbs compared with that of control limbs. Postcontrast MRI also depicted varied distribution patterns of lymphatics and abnormal lymph flow pathways within lymph nodes in the limbs with lymphatic circulation disorders.ConclusionContrast MR lymphangiography with gadobenate dimeglumine is capable of visualizing the precise anatomy of lymphatic vessels and lymph nodes in lymphedematous limbs. It also provides information concerning the functional status of lymph flow transport in the lymphatic vessels and lymph nodes of these limbs

Association between Life’s simple 7 and rheumatoid arthritis in adult Americans: data from the National Health and nutrition examination survey

ObjectiveThe study aimed to investigate the relationship between Life’s Simple 7 (LS7) and the risk of rheumatoid arthritis (RA) in adult Americans.MethodsA total of 17,532 participants were included in this study. The association between LS7 and the risk of RA was assessed using a weighted logistic regression model, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. Moreover, the nonlinear relationship was further characterized through smooth curve fitting (SCF) and weighted generalized additive model (GAM) analysis.ResultsAfter adjusting for all covariates, the weighted logistic regression model demonstrated that the LS7 was negatively correlated with the risk of RA. Compared to quintile 1 of LS7, the OR between the risk of RA and quartile 4 of LS7 (LS7.Q4) was 0.261 (95% CI, 0.203, 0.337) in males under 50 years old, while in females of the same age group, the OR was 0.183 (95% CI, 0.142, 0.234). For females aged between 50 and 70 years old, the OR between the risk of RA and LS7.Q4 was 0.313 (95% CI, 0.264, 0.371). In females aged 70 years or older, the OR between the risk of RA and LS7.Q4 was 0.632 (95% CI, 0.486, 0.822).ConclusionThis finding suggested the healthy lifestyle behaviors represented by LS7 have a negative association with RA. However, further prospective studies are needed to verify the causal relationship in the results

The expression and clinical significance of GADD45A in breast cancer patients

Background Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer. Methods We performed an immunohistochemical study of GADD45A protein from 419 breast cancer tissues and 116 adjacent non-neoplastic tissues. Results Significantly high GADD45A expression were observed in breast cancer tissues compared with adjacent non-neoplastic tissues (P < 0.001) and were independently correlative with estrogen receptor negative (P = 0.028) and high Ki-67 index (P < 0.001). Kaplan–Meier survival analysis revealed that patients with high GADD45A expression levels had a worse long-term prognosis in triple negative breast cancer (P = 0.041), but it was not an independent prognostic factor in multivariate analysis (P = 0.058). Conclusions GADD45A expression levels are significantly correlative with estrogen receptor status and Ki-67 index in human breast cancer. Patients with triple negative breast cancer might be stratified into high risk and low risk groups based on the GADD45A expression levels

Intelligent-Reflecting-Surface-Assisted UAV Communications for 6G Networks

In 6th-Generation (6G) mobile networks, Intelligent Reflective Surfaces (IRSs) and Unmanned Aerial Vehicles (UAVs) have emerged as promising technologies to address the coverage difficulties and resource constraints faced by terrestrial networks. UAVs, with their mobility and low costs, offer diverse connectivity options for mobile users and a novel deployment paradigm for 6G networks. However, the limited battery capacity of UAVs, dynamic and unpredictable channel environments, and communication resource constraints result in poor performance of traditional UAV-based networks. IRSs can not only reconstruct the wireless environment in a unique way, but also achieve wireless network relay in a cost-effective manner. Hence, it receives significant attention as a promising solution to solve the above challenges. In this article, we conduct a comprehensive survey on IRS-assisted UAV communications for 6G networks. First, primary issues, key technologies, and application scenarios of IRS-assisted UAV communications for 6G networks are introduced. Then, we put forward specific solutions to the issues of IRS-assisted UAV communications. Finally, we discuss some open issues and future research directions to guide researchers in related fields

Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes

Background: Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases with variable clinical course. Predicting disease progression is difficult due to lack of specific molecular marker(s). SALL4 plays important roles in normal hematopoiesis and leukemogenesis. SALL4 transgenic mice develop MDS prior to acute myeloid leukemia (AML) transformation. However, the role of SALL4 in human MDS has not been extensively investigated. In this study, we evaluate the diagnostic/prognostic value of SALL4 in MDS by examining its expression levels in a cohort of MDS patients. Methods: Fifty-five newly diagnosed MDS, twenty MDS-AML, and sixteen post-treatment MDS patients were selected for our study along with ten healthy donors. Results: We demonstrated that SALL4 was over-expressed in MDS patients and proportionally increased in MDS patients with high grade/IPSS scores. This expression pattern was similar to that of Bmi-1, an important marker in predicting MDS/AML progression. In addition, the level of SALL4 was positively correlated with increased blast counts, high-risk keryotypes and increased significantly in MDS-AML transformation. Furthermore, higher level of SALL4 expression was associated with worse survival rates and SALL4 level decreased following effective therapy. Conclusions: To the best of our knowledge, this is the largest series and the first to report the expression pattern of SALL4 in detail in various subtypes of MDS in comparison to that of Bmi-1. We conclude that SALL4 is a potential molecular marker in predicting the prognosis of MDS