The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome

Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular mechanisms and the physiological effects of glucocorticoids have been extensively studied. However, the involvement of glucocorticoid action in the etiology of the Metabolic Syndrome has not been well appreciated. Recently, accumulating clinical evidence and animal genetics studies have attracted growing interest in the role of glucocorticoid action in obesity and insulin resistance. This review will discuss the metabolic effects in the context of glucocorticoid metabolism and establish the association of glucocorticoid action with the features of the Metabolic Syndrome, especially obesity and insulin resistance. Special discussions will be focused on corticosteroid-binding globulin and 11β-hydroxysteroid dehydrogenase type 1, two proteins that mediate glucocorticoid action and have been implicated in the Metabolic Syndrome. Due to the complexities of the glucocorticoid biology and the Metabolic Syndrome and limited space, this review is only intended to provide a general link between the two areas with broad rather than in-depth discussions of clinical, pharmacological and genetic findings

Animatable 3D Gaussian: Fast and High-Quality Reconstruction of Multiple Human Avatars

Neural radiance fields are capable of reconstructing high-quality drivable human avatars but are expensive to train and render. To reduce consumption, we propose Animatable 3D Gaussian, which learns human avatars from input images and poses. We extend 3D Gaussians to dynamic human scenes by modeling a set of skinned 3D Gaussians and a corresponding skeleton in canonical space and deforming 3D Gaussians to posed space according to the input poses. We introduce hash-encoded shape and appearance to speed up training and propose time-dependent ambient occlusion to achieve high-quality reconstructions in scenes containing complex motions and dynamic shadows. On both novel view synthesis and novel pose synthesis tasks, our method outperforms existing methods in terms of training time, rendering speed, and reconstruction quality. Our method can be easily extended to multi-human scenes and achieve comparable novel view synthesis results on a scene with ten people in only 25 seconds of training

High-Fidelity 3D Head Avatars Reconstruction through Spatially-Varying Expression Conditioned Neural Radiance Field

One crucial aspect of 3D head avatar reconstruction lies in the details of facial expressions. Although recent NeRF-based photo-realistic 3D head avatar methods achieve high-quality avatar rendering, they still encounter challenges retaining intricate facial expression details because they overlook the potential of specific expression variations at different spatial positions when conditioning the radiance field. Motivated by this observation, we introduce a novel Spatially-Varying Expression (SVE) conditioning. The SVE can be obtained by a simple MLP-based generation network, encompassing both spatial positional features and global expression information. Benefiting from rich and diverse information of the SVE at different positions, the proposed SVE-conditioned neural radiance field can deal with intricate facial expressions and achieve realistic rendering and geometry details of high-fidelity 3D head avatars. Additionally, to further elevate the geometric and rendering quality, we introduce a new coarse-to-fine training strategy, including a geometry initialization strategy at the coarse stage and an adaptive importance sampling strategy at the fine stage. Extensive experiments indicate that our method outperforms other state-of-the-art (SOTA) methods in rendering and geometry quality on mobile phone-collected and public datasets.Comment: 9 pages, 5 figure

Simultaneous Machine Translation with Large Language Models

Large language models (LLM) have demonstrated their abilities to solve various natural language processing tasks through dialogue-based interactions. For instance, research indicates that LLMs can achieve competitive performance in offline machine translation tasks for high-resource languages. However, applying LLMs to simultaneous machine translation (SimulMT) poses many challenges, including issues related to the training-inference mismatch arising from different decoding patterns. In this paper, we explore the feasibility of utilizing LLMs for SimulMT. Building upon conventional approaches, we introduce a simple yet effective mixture policy that enables LLMs to engage in SimulMT without requiring additional training. Furthermore, after Supervised Fine-Tuning (SFT) on a mixture of full and prefix sentences, the model exhibits significant performance improvements. Our experiments, conducted with Llama2-7B-chat on nine language pairs from the MUST-C dataset, demonstrate that LLM can achieve translation quality and latency comparable to dedicated SimulMT models

Generate, Filter, and Fuse: Query Expansion via Multi-Step Keyword Generation for Zero-Shot Neural Rankers

Query expansion has been proved to be effective in improving recall and precision of first-stage retrievers, and yet its influence on a complicated, state-of-the-art cross-encoder ranker remains under-explored. We first show that directly applying the expansion techniques in the current literature to state-of-the-art neural rankers can result in deteriorated zero-shot performance. To this end, we propose GFF, a pipeline that includes a large language model and a neural ranker, to Generate, Filter, and Fuse query expansions more effectively in order to improve the zero-shot ranking metrics such as nDCG@10. Specifically, GFF first calls an instruction-following language model to generate query-related keywords through a reasoning chain. Leveraging self-consistency and reciprocal rank weighting, GFF further filters and combines the ranking results of each expanded query dynamically. By utilizing this pipeline, we show that GFF can improve the zero-shot nDCG@10 on BEIR and TREC DL 2019/2020. We also analyze different modelling choices in the GFF pipeline and shed light on the future directions in query expansion for zero-shot neural rankers

Post-processing CHARIS integral field spectrograph data with PyKLIP

We present the pyKLIP-CHARIS post-processing pipeline, a Python library that reduces high contrast imaging data for the CHARIS integral field spectrograph used with the SCExAO project on the Subaru Telescope. The pipeline is a part of the pyKLIP package, a Python library dedicated to the reduction of direct imaging data of exoplanets, brown dwarfs, and discs. For PSF subtraction, the pyKLIP-CHARIS post-processing pipeline relies on the core algorithms implemented in pyKLIP but uses image registration and calibrations that are unique to CHARIS. We describe the pipeline procedures, calibration results, and capabilities in processing imaging data acquired via the angular differential imaging and spectral differential imaging observing techniques. We showcase its performance on extracting spectra of injected synthetic point sources as well as compare the extracted spectra from real data sets on HD 33632 and HR 8799 to results in the literature. The pipeline is a python-based complement to the SCExAO project supported, widely used (and currently IDL-based) CHARIS data post-processing pipeline (CHARIS DPP) and provides an additional approach to reducing CHARIS data and extracting calibrated planet spectra.Comment: 17 pages, 13 figure

Text Style Transfer Back-Translation

Back Translation (BT) is widely used in the field of machine translation, as it has been proved effective for enhancing translation quality. However, BT mainly improves the translation of inputs that share a similar style (to be more specific, translation-like inputs), since the source side of BT data is machine-translated. For natural inputs, BT brings only slight improvements and sometimes even adverse effects. To address this issue, we propose Text Style Transfer Back Translation (TST BT), which uses a style transfer model to modify the source side of BT data. By making the style of source-side text more natural, we aim to improve the translation of natural inputs. Our experiments on various language pairs, including both high-resource and low-resource ones, demonstrate that TST BT significantly improves translation performance against popular BT benchmarks. In addition, TST BT is proved to be effective in domain adaptation so this strategy can be regarded as a general data augmentation method. Our training code and text style transfer model are open-sourced.Comment: acl2023, 14 pages, 4 figures, 19 table

Experimental Investigation on OSB Webbed Laminated Bamboo Lumber Box Shaped Joists

A novel bamboo-wood box beam was introduced in this paper, which consisted of laminated bamboo lumber flanges and OSB webs. Four-point bending tests were conducted on composite beams to investigate the effects of shear span ratio and stiffeners on failure mode and strength. The results showed that the composite beams with shear span ratio less than two failed in web shear failure, but for the others, the beams failed in twist and delamination of OSB in flanges. The load carrying capacity of beams decreased with the increase of shear span ratio. However, the mechanical performance of beams can be improved moderately by the presence of stiffeners, and theultimate bearing capacity and initial stiffness was increased by 16.5% and 13.1% respectively