TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomaviruspositive head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with about 600,000 new cases diagnosed in the last year. The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV-positive HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive HNSCC patients. TriCurin is a composition of three food-derived polyphenols in unique stoichiometric proportions consisting of curcumin from the spice turmeric, resveratrol from red grapes, and epicatechin gallate from green tea. Cell viability, clonogenic survival, and tumorsphere formation were inhibited and significant apoptosis was induced by TriCurin in UMSCC47 and UPCI:SCC090 HPV-positive HNSCC cells. Moreover, TriCurin decreased HPV16E6 and HPV16E7 and increased p53 levels. In a pre-clinical animal model of HPV-positive HNSCC, intratumoral injection of TriCurin significantly inhibited tumor growth by 85.5% compared to vehicle group (P \u3c 0.05, n = 7). Our results demonstrate that TriCurin is a potent anti-tumor agent for HPV-positive HNSCC. Further development of TriCurin as a novel anti-cancer therapeutic to manage the HPV-positive HNSCC population is warranted

Synthesis and Evaluation of Essential Oil-Derived β-Methoxyacrylate Derivatives as High Potential Fungicides

Essential oils (EOs) are plant-derived aroma compounds with a wide range of biological activity, but their actions are slow, and they are typically unstable to light or heat, difficult to extract and so on. To find highly potential fungicides derived from natural EOs, a series of essential oil-based β-methoxyacrylate derivatives have been designed and synthesized. The target compounds have been screened for their potential fungicidal activity against eleven species of plant pathogen fungi, including Alternaria alternata, Phomopsis adianticola, Pestalotiopsis theae, Sclerotinia sclerotiorum, etc. Compared with intermediates I, the parent essential oils and azoxystrobin, almost all of essential oil-based β-methoxyacrylate derivatives exhibited significantly better fungicidal activity. Further investigation revealed that some compounds showed remarkable inhibitory activities against Pestalotiopsis theae, Phomopsis adianticola, Sclerotinia sclerotiorum and Magnapothe grisea at different concentrations in contrast to the commercial product azoxystrobin. Compound II-8 exhibited particularly significant fungicidal activity

Greening Software Requirements Change Management Strategy Based on Nash Equilibrium

Recently, green computing has become more and more important in software engineering (SE), which can be achieved by effectively recycling the software system and utilizing the computing resources. However, the requirement change may lead to unnecessary labor and time cost. Moreover, it may also result in the waste of hardware and computing resources once unreasonable requirements are realized. Thus, to perform green computing in SE, it is necessary to propose effective strategies to manage the requirement change. For this decision-making problem, game theoretical methods can be feasible solutions. In this paper, we propose a novel requirement change management approach based on game theory. Specifically, we model the problem as a game between the stakeholders and the developer and devise the payoff matrix between different strategies of the players. We then propose a Nash equilibrium-based game theoretical algorithm to manage requirement change. The evaluation results show that, compared to the exhaustive algorithm, our method not only can achieve almost the same optimal results but also can significantly reduce the computational time complexity. Thus, our method is feasible for a lot of requirement changes and can facilitate the green computing targets from the perspective of software engineering

Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L−1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research

Immobilizing Polyether Imidazole Ionic Liquids on ZSM-5 Zeolite for the Catalytic Synthesis of Propylene Carbonate from Carbon Dioxide

Traditional ionic liquids (ILs) catalysts suffer from the difficulty of product purification and can only be used in homogeneous catalytic systems. In this work, by reacting ILs with co-catalyst (ZnBr2), we successfully converted three polyether imidazole ionic liquids (PIILs), i.e., HO-[Poly-epichlorohydrin-methimidazole]Cl (HO-[PECH-MIM]Cl), HOOC-[Poly-epichlorohydrin-methimidazole]Cl (HOOC-[PECH-MIM]Cl), and H2N-[Poly-epichlorohydrin-methimidazole]Cl (H2N-[PECH-MIM]Cl), to three composite PIIL materials, which were further immobilized on ZSM-5 zeolite by chemical bonding to result in three immobilized catalysts, namely ZSM-5-HO-[PECH-MIM]Cl/[ZnBr2], ZSM-5-HOOC-[PECH-MIM]Cl/[ZnBr2], and ZSM-5-H2N-[PECH-MIM]Cl/[ZnBr2]. Their structures, thermal stabilities, and morphologies were fully characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The amount of composite PIIL immobilized on ZSM-5 was determined by elemental analysis. Catalytic performance of the immobilized catalysts was evaluated through the catalytic synthesis of propylene carbonate (PC) from CO2 and propylene oxide (PO). Influences of reaction temperature, time, and pressure on catalytic performance were investigated through the orthogonal test, and the effect of catalyst circulation was also studied. Under an optimal reaction condition (130 °C, 2.5 MPa, 0.75 h), the composite catalyst, ZSM-5-HOOC- [PECH-MIM]Cl/[ZnBr2], exhibited the best catalytic activity with a conversion rate of 98.3% and selectivity of 97.4%. Significantly, the immobilized catalyst could still maintain high heterogeneous catalytic activity even after being reused for eight cycles

Temporal Associations between Tri-Ponderal Mass Index and Blood Pressure in Chinese Children: A Cross-Lag Analysis

Background: No longitudinal studies have explored the relationship between tri-ponderal mass index (TMI) and blood pressure (BP) in children. This study is aimed to investigate the temporal associations between TMI and BP among children in China. Methods: A longitudinal study was carried out with Chinese children from 2014 to 2019. Data of the anthropometric examination and blood pressure were collected annually. TMI was calculated by dividing weight by the cube of height. BP was measured using a standard mercury sphygmomanometer. We investigated temporal associations between TMI and BP with a cross-lagged panel model using repeated measure data from 2014 (Wave 1), 2016 (Wave 2), and 2018 (Wave 3). Results: Results of the cross-lagged panel model showed that TMI was associated with subsequent BP. Participants with higher levels of TMI presented higher levels of BP (Wave 1: β = 0.737 for systolic blood pressure (SBP) and β = 0.308 for diastolic blood pressure (DBP), Wave 2: β = 0.422 for SBP and β = 0.165 for DBP, p p < 0.01), but the cross-lag path coefficient indicated that the influence of TMI on BP was stronger than the influence of BP on TMI. Conclusions: There was a temporal association between TMI and BP in Chinese children. Higher TMI predicted higher subsequent BP rather than the reverse relationship

Energy Saving and Thermal Comfort Performance of Passive Retrofitting Measures for Traditional Rammed Earth House in Lingnan, China

The traditional rammed earth houses sharing similar patterns in the Lingnan region, south China, and distributed in rectangular arrays, are gradually losing their vitality and becoming uninhabited under modern living conditions. This research examined a typical pattern called the “Four-point gold” house and analyzed the suitability of different retrofitting technologies by field measurements and building simulation. To optimize energy consumption, indoor thermal comfort, and the corresponding economic performance of the retrofitting measures for the prototypical house, five measures, including wall insulation, reflective roof coating, carpet, sunshade, and natural ventilation, are proposed after considering the status quo of the building envelope. It is found that the best performance in energy-saving, dynamic investment payback period, and annual indoor thermal comfort are 2192.27 kWh/a, 9.17 years, and 1766 h, respectively. Different parameters are included to be clustered by K means clustering technique, and the comprehensively optimized scheme consists of a regime of 30 mm XPS 30 mm, ZS-221 white coating, carpet, 0.5 m sunshade width, and turning off windows (doors). The proposed retrofitting strategy can be promoted to a wide range of traditional rammed earth houses in the Lingnan region in China and holds a conspicuous energy-saving potential for the suburban and rural residential sectors in the region

Identifying priority sites and gaps for the conservation of migratory waterbirds in China's coastal wetlands

Many waterbird species, in particularly migratory shorebirds, on the East Asian-Australasian Flyway depend on the intertidal areas of coastal China. In recent years, these habitats have suffered severe shrinkage as a result of wetland loss and degradation. Identifying critical areas for waterbirds and assessing conservation status has become an urgent priority for biological conservation. Based on the criteria used to designate Ramsar sites and East Asian-Australasian Flyway Partnership (EAAFP) Flyway Network sites, a general framework is proposed and applied to identify priority sites in China's coastal wetlands using a comprehensive waterbird survey dataset. Sites priority were evaluated by using appearance of globally threatened bird species, and bid species exceeding 1% of their global or flyway population, and population abundance. Sites priorities were ranked using an "irreplaceability index". Totally, 110 sites are proposed as priority sites. Considering the strategic importance of China's coastal wetlands for migratory waterbirds, the conservation status of China's coastal wetlands is inadequate to protect these waterbirds. Currently, 67 of the 110 priority sites lie outside protected areas. Some critical habitats for waterbirds are not included in individual protected areas, especially in Jiangsu, Zhejiang, and. Hebei provinces. Improved protection of these areas is urgently needed. However, conservation efforts in China's coastal wetlands face numerous challenges. Many important intertidal areas are increasingly threatened by ongoing and future reclamation plans. There is an urgent need to re-consider and limit the reclamation, particularly at critical sites, and put in place conservation measures to protect migratory waterbirds and their habitats. (C) 2016 Elsevier Ltd. All rights reserved