The `Periodic Nulls' of Radio Pulsar J1819+1305

We present a single-pulse study of the four-component pulsar J1819+1305, whose ``null'' pulses bunch at periodic intervals of around 57 times the rotation period. The emission bursts between the null bunches exhibit characteristic modulations at two shorter periodicities of approximately 6.2 and 3 times the rotation period, the former found largely in the two outer components, and the latter only in the first component. Many bursts commence with bright emission in second component, exhibit positive six-period drift across the full profile width, and end with 3-period modulation in the leading component. The 57-period cycle can be modelled geometrically as a sparsely filled subbeam carousel with nulls appearing whenever our line of sight intersects a circulating empty region. This interpretation is compatible with other recent evidence for periodic, carousel-related nulling and appears to support the physics of a polar-gap emission model for ``drifting'' subpulses, but the subtle structure of the emission bursts defies an easy explanation.Comment: 8 pages, 9 figure

High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice

Phagocytosis had been attributed predominantly to "professional" phagocytes such as macrophages, which play critical roles in adipose tissue inflammation. However, recently, macrophage-like phagocytic activity has been reported in B1 B lymphocytes. Intrigued by the long-established correlation between high fat diet (HFD)-induced obesity and immune dysfunction, we investigated how HFD affects B1 B cell phagocytosis. A significant number of B1 B cells recognize phosphatidylcholine (PtC), a common phospholipid component of cell membrane. We report here that unlike macrophages, B1 B cells have a unique PtC-specific phagocytic function. In the presence of both PtC-coated and non-PtC control fluorescent nano-particles, B1 B cells from healthy lean mice selectively engulfed PtC-coated beads, whereas B1 B cells from HFD-fed obese mice non-discriminately phagocytosed both PtC-coated and control beads. Morphologically, B1 B cells from obese mice resembled macrophages, displaying enlarged cytosol and engulfed more beads. Our study suggests for the first time that HFD can affect B1 B cell phagocytosis, substantiating the link of HFD-induced obesity and immune deviation.R21 AR063387 - NIAMS NIH HHS; R25 CA153955 - NCI NIH HHS; UL1 TR000157 - NCATS NIH HH

The first symbiotic stars from the LAMOST survey

Symbiotic stars are interacting binary systems with the longest orbital periods. They are typically formed by a white dwarf, a red giant and a nebula. These objects are natural astrophysical laboratories for studying the evolution of binaries. Current estimates of the population of Milky Way symbiotic stars vary from 3000 up to 400000. However, the current census is less than 300. The Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST) survey can obtain hundreds of thousands of stellar spectra per year, providing a good opportunity to search for new symbiotic stars. In this work we detect 4 of such binaries among 4,147,802 spectra released by the LAMOST, of which two are new identifications. The first is LAMOST J12280490-014825.7, considered to be an S-type halo symbiotic star. The second is LAMOST J202629.80+423652.0, a D-type symbiotic star

Post-Project Appraisal in Social Relationships between the Ecological Restoration Project on Stoney Creek and the Surrounding Community, Burnaby, British Columbia

Scientific studies upon ecological restoration projects and their relation to nearby environments such as soil quality, invasive species, beetles living habitat have been studied extensively by varies research groups. However, researchers seem to have neglected the social relation between residence and the ecological restoration project. Knowledge on public attitudes and perceptions toward ecological restoration projects is essential in exploring the public’s degree of supportiveness and in creating a sustainable restoration project. Using Stoney Creek in Burnaby, British Columbia as a case study, this study searches for the relationship between community members attitudes and knowledge towards ecological restoration by examining the correlation of the resident’s place attachment, length of residency, and their willingness to engage. The study has found a direct relation between public’s interest in ecological restoration and their willingness to engage. The public’s willingness to engage also has a relation to their attachment to the creek. The public’s awareness and knowledge is related to the residents’ attachment to Stoney Creek and the duration of residency in the area. Proximity to the creek, however, does not seem to have a correlation to the public’s perception of Stoney Creek’s ecological restoration project

Calnexin Is Necessary for T Cell Transmigration into the Central Nervous System

In multiple sclerosis (MS), a demyelinating inflammatory disease of the CNS, and its animal model (experimental autoimmune encephalomyelitis; EAE), circulating immune cells gain access to the CNS across the blood-brain barrier to cause inflammation, myelin destruction, and neuronal damage. Here, we discovered that calnexin, an ER chaperone, is highly abundant in human brain endothelial cells of MS patients. Conversely, mice lacking calnexin exhibited resistance to EAE induction, no evidence of immune cell infiltration into the CNS, and no induction of inflammation markers within the CNS. Furthermore, calnexin deficiency in mice did not alter the development or function of the immune system. Instead, the loss of calnexin led to a defect in brain endothelial cell function that resulted in reduced T cell trafficking across the blood-brain barrier. These findings identify calnexin in brain endothelial cells as a potentially novel target for developing strategies aimed at managing or preventing the pathogenic cascade that drives neuroinflammation and destruction of the myelin sheath in MS