The relationship between activated H2 bond length and adsorption distance on MXenes identified with graph neural network and resonating valence bond theory

Motivated by the recent experimental study on hydrogen storage in MXene multilayers [Nature Nanotechnol. 2021, 16, 331], for the first time we propose a workflow to computationally screen 23,857 compounds of MXene to explore the general relation between the activated H2 bond length and adsorption distance. By using density functional theory (DFT), we generate a dataset to investigate the adsorption geometries of hydrogen on MXenes, based on which we train physics-informed atomistic line graph neural networks (ALIGNNs) to predict adsorption parameters. To fit the results, we further derived a formula that quantitatively reproduces the dependence of H2 bond length on the adsorption distance from MXenes within the framework of Pauling's resonating valence bond (RVB) theory, revealing the impact of transition metal's ligancy and valence on activating dihydrogen in H2 storage

TRIM29 acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma.

Epigenetic alterations marked by DNA methylation are frequent events during the early development of nasopharyngeal carcinoma (NPC). We identified that TRIM29 is hypomethylated and overexpressed in NPC cell lines and tissues. TRIM29 silencing not only limited the growth of NPC cells in vitro and in vivo, but also induced cellular senescence, along with reactive oxygen species (ROS) accumulation. Mechanistically, we found that TRIM29 interacted with voltage-dependent anion-selective channel 1 (VDAC1) to activate mitophagy clearing up damaged mitochondria, which are the major source of ROS. In patients with NPC, high levels of TRIM29 expression are associated with an advanced clinical stage. Moreover, we detected hypomethylation of TRIM29 in patient nasopharyngeal swab DNA. Our findings indicate that TRIM29 depends on VDAC1 to induce mitophagy and prevents cellular senescence by decreasing ROS. Detection of aberrantly methylated TRIM29 in the nasopharyngeal swab DNA could be a promising strategy for the early detection of NPC

Femtosecond Laser Filamentation in Atmospheric Turbulence

The effects of turbulence intensity and turbulence region on the distribution of femtosecond laser filaments are experimentally elaborated. Through the ultrasonic signals emitted by the filaments, and it is observed that increasing turbulence intensity and expanding turbulence active region cause an increase in the start position of the filament, and a decrease in filament length, which can be well explained by the theoretical calculation. It is also observed that the random perturbation of the air refractive index caused by atmospheric turbulence expanded the spot size of the filament. Additionally, when turbulence intensity reaches , multiple filaments are formed. Furthermore, the standard deviation of the transverse displacement of filament is found to be proportional to the square root of turbulent structure constant under the experimental turbulence parameters in this paper. These results contribute to the study of femtosecond laser propagation mechanisms in complex atmospheric turbulence conditionsComment: 9 pages, 4 figure

Effects of misalignment on the nonlinear dynamics of a two-shaft rotor-bearing-gear coupling system with rub-impact fault

In rotor-bearing system, the misalignment can lead to secondary faults, such as the rub-impact fault. How the development of misalignment could affect the rub-impact force and other dynamic responses is important for the vibration control and fault diagnosis of rotor system. In this paper, a mathematical model of a two-shaft rotor-bearing- gear coupling system is established. The model is validated through the misaligned force of gear coupling, the supporting force of the lubricated ball bearing and the whole rotor response. To overcome the limit of traditional approaches and further dig out fault characteristics, the time-frequency method is introduced to analyze the dynamic response from both the time and frequency domains points of view. It is found the misalignment effect on rotor dynamic responses is mainly focused in high rotating speed range. The development of misalignment has an obvious adverse effect on the rotor stability. Some intermittent components in low frequency range due to the occurrence and development of misalignment can be found affecting the rotor stability at low speed range, and the high frequency rub-impact components can be found responsible for the unstable state of rotor

Coupled air lasing gain and Mie scattering loss: aerosol effect in filament-induced plasma spectroscopy

Femtosecond laser filament-induced plasma spectroscopy (FIPS) demonstrates great potentials in the remote sensing for identifying atmospheric pollutant molecules. Due to the widespread aerosols in atmosphere, the remote detection based on FIPS would be affected from both the excitation and the propagation of fingerprint fluorescence, which still remain elusive. Here the physical model of filament-induced aerosol fluorescence is established to reveal the combined effect of Mie scattering and amplification spontaneous emission, which is then proved by the experimental results, the dependence of the backward fluorescence on the interaction length between filament and aerosols. These findings provide an insight into the complicated aerosol effect in the overall physical process of FIPS including propagation, excitation and emission, paving the way to its practical application in atmospheric remote sensing.Comment: 7 pages, 4 figure

A demand-response method to balance electric power-grids via HVAC systems using active energy-storage: simulation and on-site experiment

With the increasing popularity of renewable energy sources and the globally increasing electricity demand, the task of balancing the intermittent energy supply with varying demand becomes increasingly difficult. Instead of adjusting the supply, improving the demand response (DR) can be a more efficient way to optimize power balance. HVAC (heating, ventilation, and air-conditioning) systems, which operate on the demand side of power-grids, have a huge potential to improve the power balance. To assess their potential in a variable air volume (VAV) air-conditioning system with energy storage tank we introduce a demand response method that combines active cool-energy storage (ACES) with global temperature adjustment (GTA). To confirm the effectiveness of this combined ACES+GTA approach, we conduct measurements with the help of a full-scale VAV air-conditioning test setup. The experimental results are compared with a TRNSYS simulation. The measurements indicate that an energy-storing water-tank can effectively reduce the number of starts and stops for the heat pump. The simulation confirms that the ACES+GTA method can also effectively reduce the peak load of the power grid with little impact on the thermal comfort of the energy consumers. The cost-saving rate, compared to the conventional operating mode (no energy-storage during other periods), reaches 7.02% for an entire cooling season if the GTA method (with DR) is used

Giant Brunner’s gland adenoma of the duodenum complicated with bleeding: a case report

Brunner’s gland adenoma（BGA） of the duodenum is an extremely rare benign tumor in clinical practice. In this article， the diagnosis and treatment of one case of BGA of the duodenum were reported. The patient had a history of anemia for 4 years， but she never received tests to identify the cause. She was admitted to Department of Neurology for the first time due to dizziness， and was transferred to our department due to gastrointestinal bleeding during hospitalization. Hemorrhagic shock and transient syncope occurred during treatment， which were alleviated after drug therapy. Then， gastroscopy was immediately performed and showed protrusion lesions in the descending duodenum. The diagnosis of BGA was finally confirmed by endoscopic pathological resection. This article aiming to deepen the gastroenterologists / endoscopists’ understanding of BGA and improve the diagnostic and therapeutic levels