DO HEALTH CLAIMS MATTER FOR CONSUMER PREFERENCE ON TEA BEVERAGE? EXPERIMENTAL EVIDENCE FROM TAIWAN

This paper aims to identify consumer preference for tea drinking products in Taiwan by applying conjoint analysis and investigate whether health claims as attributes would influence consumer’s choice behavior. From 1 July to 31 August 2005, 620 consumers of tea drinking products participated in the choice-based conjoint experiment, which conducted in the city of Taipei, Taichung, Tainan, and Kaohsiung in Taiwan. The data were collected in supermarket using questionnaire for personal interviews. Overall, the estimated individual models fit the data well using Conditional Logit Model. Regarding the result of “Original Tea”, consumer’s order ranking of tea category is green tea, oolong tea, and black tea. The most importance on the standard that health claims have positive influence on higher likelihood of purchasing tea drinks. In addition, consumer prefers to tea drinks with Catechins, processing technology using cold extraction, and paper package. However, it could be seen that as the price increases the utility for the consumer decreases. Also, we report the negative relationship between price and purchasing intention. It is found that respondents preferred to tea drinking products with health claims. This result stands for consumer’s concern on their health status by intaking additives like Catechins. Our results also suggest that respondents prefer that tea drinks include less sugar that implies that the product is produced “light”.Tea Drinking Products, Consumer Preference, Health Claims, Conjoint Analysis, Conditional Logit Model, Agricultural and Food Policy, Consumer/Household Economics, Demand and Price Analysis, Food Consumption/Nutrition/Food Safety, Food Security and Poverty, Health Economics and Policy,

Exceptional and Anisotropic Transport Properties of Photocarriers in Black Phosphorus

We show that black phosphorus has room-temperature charge mobilities on the order of 10$^4$ cm$^2$V$^{-1}$s$^{-1}$, which are about one order of magnitude larger than silicon. We also demonstrate strong anisotropic transport in black phosphorus, where the mobilities along the armchair direction are about one order of magnitude larger than zigzag direction. A photocarrier lifetime as long as 100 ps is also determined. These results illustrate that black phosphorus is a promising candidate for future electronic and optoelectronic applications.Comment: 5 pages, 4 figure

Exploring Taiwan citizens’ scientific literacy, interest in, and engagement in learning science

This study explored Taiwan citizens' scientific literacy, interest in, and engagement in learning science. By using the stratified random sampling strategy, 1,831 citizens in the age group of 18-70 years were selected to respond to a questionnaire survey along with a paper-pencil test. For exploring the relationship between Taiwan citizens' scientific literacy and their interest in science, the participants were divided into four groups on the basis of their scores for scientific literacy and interest in science. According to the essential results, the high scientific literacy and high science interest (HH) group was mainly represented by males, young citizens, and citizens with higher educational degrees. Conversely, the low scientific literacy and low science interest (LL) group was dominated by females, elderly citizens, and citizens with only a secondary school diploma. Among the four groups, citizens in the HH and LH groups exhibited higher frequency of engagement in science activities. Finally, citizens with high science interest tended to be enthusiastic in learning science and technology. This study contributed a novel insight that the interest in learning science plays a critical role in promoting adults' engagement in learning science. Future studies are recommended for focusing on the citizens in the LH group to investigate how high engagement in learning science influences their scientific literacy

Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic acid

<p>Abstract</p> <p>Background</p> <p>Lipoteichoic acid (LTA) is a component of Gram-positive bacterial cell walls, which has been found to be elevated in cerebrospinal fluid of patients suffering from meningitis. Moreover, matrix metalloproteinases (MMPs), MMP-9 especially, have been observed in patients with brain inflammatory diseases and may contribute to brain disease pathology. However, the molecular mechanisms underlying LTA-induced MMP-9 expression in brain astrocytes remain unclear.</p> <p>Objective</p> <p>The goal of this study was to examine whether LTA-induced cell migration is mediated by calcium/calmodulin (CaM)/CaM kinase II (CaMKII)-dependent transactivation of the PDGFR pathway in rat brain astrocytes (RBA-1 cells).</p> <p>Methods</p> <p>Expression and activity of MMP-9 induced by LTA was evaluated by zymographic, western blotting, and RT-PCR analyses. MMP-9 regulatory signaling pathways were investigated by treatment with pharmacological inhibitors or using dominant negative mutants or short hairpin RNA (shRNA) transfection, and chromatin immunoprecipitation (ChIP)-PCR and promoter activity reporter assays. Finally, we determined the cell functional changes by cell migration assay.</p> <p>Results</p> <p>The data show that c-Jun/AP-1 mediates LTA-induced MMP-9 expression in RBA-1 cells. Next, we demonstrated that LTA induces MMP-9 expression via a calcium/CaM/CaMKII-dependent transactivation of PDGFR pathway. Transactivation of PDGFR led to activation of PI3K/Akt and JNK1/2 and then activated c-Jun/AP-1 signaling. Activated-c-Jun bound to the AP-1-binding site of the MMP-9 promoter, and thereby turned on transcription of MMP-9. Eventually, up-regulation of MMP-9 by LTA enhanced cell migration of astrocytes.</p> <p>Conclusions</p> <p>These results demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by LTA. Understanding the regulatory mechanisms underlying LTA-induced MMP-9 expression and functional changes in astrocytes may provide a new therapeutic strategy for Gram-positive bacterial infections in brain disorders.</p

Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are regulated during the cell cycle, and recent studies reveal that Skp2 stability, subcellular localization, and activity are regulated by its phosphorylation. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers

Role of SiNx Barrier Layer on the Performances of Polyimide Ga2O3-doped ZnO p-i-n Hydrogenated Amorphous Silicon Thin Film Solar Cells

In this study, silicon nitride (SiNx) thin films were deposited on polyimide (PI) substrates as barrier layers by a plasma enhanced chemical vapor deposition (PECVD) system. The gallium-doped zinc oxide (GZO) thin films were deposited on PI and SiNx/PI substrates at room temperature (RT), 100 and 200 °C by radio frequency (RF) magnetron sputtering. The thicknesses of the GZO and SiNx thin films were controlled at around 160 ± 12 nm and 150 ± 10 nm, respectively. The optimal deposition parameters for the SiNx thin films were a working pressure of 800 × 10−3 Torr, a deposition power of 20 W, a deposition temperature of 200 °C, and gas flowing rates of SiH4 = 20 sccm and NH3 = 210 sccm, respectively. For the GZO/PI and GZO-SiNx/PI structures we had found that the GZO thin films deposited at 100 and 200 °C had higher crystallinity, higher electron mobility, larger carrier concentration, smaller resistivity, and higher optical transmittance ratio. For that, the GZO thin films deposited at 100 and 200 °C on PI and SiNx/PI substrates with thickness of ~1000 nm were used to fabricate p-i-n hydrogenated amorphous silicon (α-Si) thin film solar cells. 0.5% HCl solution was used to etch the surfaces of the GZO/PI and GZO-SiNx/PI substrates. Finally, PECVD system was used to deposit α-Si thin film onto the etched surfaces of the GZO/PI and GZO-SiNx/PI substrates to fabricate α-Si thin film solar cells, and the solar cells’ properties were also investigated. We had found that substrates to get the optimally solar cells’ efficiency were 200 °C-deposited GZO-SiNx/PI

6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation

Physical interaction between Nur77 and p65. BV-2 cells were pretreated with 6-MP (50 μM) for 16 h followed by exposure to LPS (100 ng/ml) for 60 min. Nuclear extracts were harvested for immunoprecipitation (IP) experiments using anti-Nur77 and anti-p65 antibodies. Immunoblot (IB) analyses of the immunoprecipitates were performed using these antibodies. The immunoblots are representative of three independent experiments. (TIF 280 kb