Families of jets of arc type and higher (co)dimensional Du Val singularities

Families of jets through singularities of algebraic varieties are here studied in relation to the families of arcs originally studied by Nash. After proving a general result relating them, we look at normal locally complete intersection varieties with rational singularities and focus on a class of singularities we call "higher Du Val singularities", a higher dimensional (and codimensional) version of Du Val singularities that is closely related to Arnold singularities. More generally, we introduce the notion of "higher compound Du Val singularities", whose definition parallels that of compound Du Val singularities. For such singularities, we prove that there exists a one-to-one correspondence between families of arcs and families of jets of sufficiently high order through the singularities. In dimension two, the result partially recovers a theorem of Mourtada on the jet schemes of Du Val singularities. As an application, we give a solution of the Nash problem for higher Du Val singularities.Comment: v2: 22 pages; to appear in C. R. Math. Acad. Sci. Paris, special volume in memory of Jean-Pierre Demaill

A Study of Using Cepstrogram for Countermeasure Against Replay Attacks

In this paper, we investigate the properties of the cepstrogram and demonstrate its effectiveness as a powerful feature for countermeasure against replay attacks. Cepstrum analysis of replay attacks suggests that crucial information for anti-spoofing against replay attacks may retain in the cepstrogram. Experimental results on the ASVspoof 2019 physical access (PA) database demonstrate that, compared with other features, the cepstrogram dominates in both single and fusion systems when building countermeasures against replay attacks. Our LCNN-based single and fusion systems with the cepstrogram feature outperform the corresponding LCNN-based systems without using the cepstrogram feature and several state-of-the-art (SOTA) single and fusion systems in the literature.Comment: Submitted to INTERSPEECH 202

Navier-Stokes flow field analysis of compressible flow in a high pressure safety relief valve

The objective of this study is to investigate the complex three-dimensional flowfield of an oxygen safety pressure relieve valve during an incident, with a computational fluid dynamic (CFD) analysis. Specifically, the analysis will provide a flow pattern that would lead to the expansion of the eventual erosion pattern of the hardware, so as to combine it with other findings to piece together a most likely scenario for the investigation. The CFD model is a pressure based solver. An adaptive upwind difference scheme is employed for the spatial discretization, and a predictor, multiple corrector method is used for the velocity-pressure coupling. The computational result indicated vortices formation near the opening of the valve which matched the erosion pattern of the damaged hardware

Homogeneous point mutation detection by quantum dot-mediated two-color fluorescence coincidence analysis

This report describes a new genotyping method capable of detecting low-abundant point mutations in a homogeneous, separation-free format. The method is based on integration of oligonucleotide ligation with a semiconductor quantum dot (QD)-mediated two-color fluorescence coincidence detection scheme. Surface-functionalized QDs are used to capture fluorophore-labeled ligation products, forming QD-oligonucleotide nanoassemblies. The presence of such nanoassemblies and thereby the genotype of the sample is determined by detecting the simultaneous emissions of QDs and fluorophores that occurs whenever a single nanoassembly flows through the femtoliter measurement volume of a confocal fluorescence detection system. The ability of this method to detect single events enables analysis of target signals with a multiple-parameter (intensities and count rates of the digitized target signals) approach to enhance assay sensitivity and specificity. We demonstrate that this new method is capable of detecting zeptomoles of targets and achieve an allele discrimination selectivity factor >10(5)

Cloning, expression and CNS distribution of Kv4.3, an A-type K+ channel α subunit

AbstractA full-length K+ channel cDNA of Kv4.3, with an open reading frame of 611 amino acids, was isolated from rat hippocampus. Functional expression of Kv4.3 cDNA in Xenopus oocytes revealed an A-type K+ channel. In the central nervous system, Kv4.3 is most prominently expressed in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum, as well as lateral geniculate and superior colliculus, which are important for vision. The abundant expression of Kv4.3 in many CNS neurons supports its important role as a major component of subthreshold A currents in the control of action potentials and thus neuronal excitability