Controllable Andreev retroreflection and specular Andreev reflection in a four-terminal graphene-superconductor hybrid system

We report the investigation of electron transport through a four-terminal graphene-superconductor hybrid system. Due to the quantum interference of the reflected holes from two graphene-superconductor interfaces with phase difference $\theta$, it is found that the specular Andreev reflection vanishes at $\theta=0$ while the Andreev retroreflection disappears at $\theta=\pi$. This means that the retroreflection and specular reflection can be easily controlled and separated in this device. In addition, due to the diffraction effect in the narrow graphene nanoribbon, the reflected hole can exit from both graphene terminals. As the width of nanoribbon increases, the diffraction effect gradually disappears and the reflected hole eventually exits from a particular graphene terminal depending on the type of Andreev reflection.Comment: 4 pages, 5 figure

Ionic effect on combing of single DNA molecules and observation of their force-induced melting by fluorescence microscopy

Molecular combing is a powerful and simple method for aligning DNA molecules onto a surface. Using this technique combined with fluorescence microscopy, we observed that the length of lambda-DNA molecules was extended to about 1.6 times their contour length (unextended length, 16.2 micrometers) by the combing method on hydrophobic polymethylmetacrylate (PMMA) coated surfaces. The effects of sodium and magnesium ions and pH of the DNA solution were investigated. Interestingly, we observed force-induced melting of single DNA molecules.Comment: 12 page

A multi-wavelength observation and investigation of six infrared dark clouds

Context. Infrared dark clouds (IRDCs) are ubiquitous in the Milky Way, yet they play a crucial role in breeding newly-formed stars. Aims. With the aim of further understanding the dynamics, chemistry, and evolution of IRDCs, we carried out multi-wavelength observations on a small sample. Methods. We performed new observations with the IRAM 30 m and CSO 10.4 m telescopes, with tracers ${\rm HCO^+}$, HCN, ${\rm N_2H^+}$, ${\rm C^{18}O}$, DCO$^+$, SiO, and DCN toward six IRDCs G031.97+00.07, G033.69-00.01, G034.43+00.24, G035.39-00.33, G038.95-00.47, and G053.11+00.05. Results. We investigated 44 cores including 37 cores reported in previous work and seven newly-identified cores. Toward the dense cores, we detected 6 DCO$^+$, and 5 DCN lines. Using pixel-by-pixel spectral energy distribution (SED) fits of the $\textit{Herschel}$ 70 to 500 $\mu$m, we obtained dust temperature and column density distributions of the IRDCs. We found that ${\rm N_2H^+}$ emission has a strong correlation with the dust temperature and column density distributions, while ${\rm C^{18}O}$ showed the weakest correlation. It is suggested that ${\rm N_2H^+}$ is indeed a good tracer in very dense conditions, but ${\rm C^{18}O}$ is an unreliable one, as it has a relatively low critical density and is vulnerable to freezing-out onto the surface of cold dust grains. The dynamics within IRDCs are active, with infall, outflow, and collapse; the spectra are abundant especially in deuterium species. Conclusions. We observe many blueshifted and redshifted profiles, respectively, with ${\rm HCO^+}$ and ${\rm C^{18}O}$ toward the same core. This case can be well explained by model "envelope expansion with core collapse (EECC)".Comment: 24 pages, 11 figures, 4 tables. To be published in A&A. The resolutions of the pictures are cut dow

Weighted Change-Point Method for Detecting Differential Gene Expression in Breast Cancer Microarray Data

In previous work, we proposed a method for detecting differential gene expression based on change-point of expression profile. This non-parametric change-point method gave promising result in both simulation study and public dataset experiment. However, the performance is still limited by the less sensitiveness to the right bound and the statistical significance of the statistics has not been fully explored. To overcome the insensitiveness to the right bound we modified the original method by adding a weight function to the Dn statistic. Simulation study showed that the weighted change-point statistics method is significantly better than the original NPCPS in terms of ROC, false positive rate, as well as change-point estimate. The mean absolute error of the estimated change-point by weighted change-point method was 0.03, reduced by more than 50% comparing with the original 0.06, and the mean FPR was reduced by more than 55%. Experiment on microarray Dataset I resulted in 3974 differentially expressed genes out of total 5293 genes; experiment on microarray Dataset II resulted in 9983 differentially expressed genes among total 12576 genes. In summary, the method proposed here is an effective modification to the previous method especially when only a small subset of cancer samples has DGE

Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS

Unraveling Gluon Jet Quenching through J/ψJ/\psi Production in Heavy-Ion Collisions

Jet quenching has long been regarded as one of the key signatures for the formation of quark-gluon plasma in heavy-ion collisions. Despite significant efforts, the separate identification of quark and gluon jet quenching has remained as a challenge. Here we show that $J/\psi$ in high transverse momentum ($p_\text{T}$) region provides a uniquely sensitive probe of in-medium gluon energy loss since its production at high $p_\text{T}$ is particularly dominated by gluon fragmentation. Such gluon-dominance is first demonstrated for the baseline of proton-proton collisions within the framework of leading power NRQCD factorization formalism. We then use the linear Boltzmann transport model combined with hydrodynamics for the simulation of jet-medium interaction in nucleus-nucleus collisions. The satisfactory description of experimental data on both nuclear modification factor $R_{\text{AA}}$ and elliptic flow $v_2$ reveals, for the first time, that the gluon jet quenching is the driving force for high $p_\text{T}$ $J/\psi$ suppression. This novel finding is further confirmed by the data-driven Bayesian analyses of relevant experimental measurements, from which we also obtain the first quantitative extraction of the gluon energy loss distribution in the quark-gluon plasma.Comment: 7 pages, 5 figures, version published in Science Bulleti

Coherent phonon Rabi oscillations with a high frequency carbon nanotube phonon cavity

Phonon-cavity electromechanics allows the manipulation of mechanical oscillations similar to photon-cavity systems. Many advances on this subject have been achieved in various materials. In addition, the coherent phonon transfer (phonon Rabi oscillations) between the phonon cavity mode and another oscillation mode has attracted many interest in nano-science. Here we demonstrate coherent phonon transfer in a carbon nanotube phonon-cavity system with two mechanical modes exhibiting strong dynamical coupling. The gate-tunable phonon oscillation modes are manipulated and detected by extending the red-detuned pump idea of photonic cavity electromechanics. The first- and second-order coherent phonon transfers are observed with Rabi frequencies 591 kHz and 125 kHz, respectively. The frequency quality factor product fQ_m~2=10^12 Hz achieved here is larger thank k_B T_base/h, which may enable the future realization of Rabi oscillations in the quantum regime